Composite protein peptide with skin care efficacy, hydrogel thereof and preparation method

A technology of compound protein and compound protease, which is applied in the field of compound protein peptide and its hydrogel and preparation, can solve the problems of inability to improve skin structure, inability to form a protective film, weakening of anti-oxidation and moisturizing effect, and prevent skin dryness Wrinkles and aging, inhibition of melanin production, good appearance and luster

Inactive Publication Date: 2016-08-31
广州中科国典环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this process, the invention cannot form a protective film on the skin surface, and catechin and vitamin C are easily oxidized in the air, resulting in greatly weakened anti-oxidation and moisturizing effects
Moreover, the protein source of ex...

Method used

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  • Composite protein peptide with skin care efficacy, hydrogel thereof and preparation method
  • Composite protein peptide with skin care efficacy, hydrogel thereof and preparation method
  • Composite protein peptide with skin care efficacy, hydrogel thereof and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A kind of composite protein peptide hydrogel of this embodiment is prepared from the following components in terms of mass percentage:

[0054]

[0055]

[0056] The preparation method of above-mentioned silk fibroin peptide comprises the following steps:

[0057] (1) the complete silk fibroin (silkworm cocoon shell) that has been degummed is placed in 50wt% CaCl 2 In aqueous solution (silk fibroin and CaCl 2 The mass ratio of the aqueous solution is 1:18), heated to 80° C., stirred and dissolved, and after the solution was cooled, dialyzed with water for desalination, and concentrated to obtain a silk fibroin solution with a concentration of 10 wt %;

[0058] (2) Adjust the pH value of the silk fibroin solution to 5, add 1000U / g compound protease (35wt% alkaline protease+65wt% papain), adjust the enzymolysis temperature to 30°C, and enzymolysis for 4 hours;

[0059] (3) After enzymatic hydrolysis, heat to 100° C. to inactivate the enzyme, and freeze-dry the mixed...

Embodiment 2

[0065] A kind of composite protein peptide hydrogel of this embodiment is prepared from the following components in terms of mass percentage:

[0066]

[0067]

[0068] The preparation method of above-mentioned silk fibroin peptide comprises the following steps:

[0069] (1) the complete silk fibroin (silkworm cocoon shell) that has been degummed is placed in 50wt% CaCl 2 In aqueous solution (silk fibroin and CaCl 2 The mass ratio of the aqueous solution is 1:10), heated to 80°C and stirred to dissolve. After the solution is cooled, dialyze and desalt with water, and concentrate to obtain a silk fibroin solution with a concentration of 10 wt%.

[0070] (2) Adjust the pH value of the silk fibroin solution to 7, add 1600U / g compound protease (23wt% papain+77wt% trypsin), adjust the enzymolysis temperature to 25°C, and enzymolysis for 6.5 hours;

[0071] (3) After enzymatic hydrolysis, heat to 100° C. to inactivate the enzyme, and freeze-dry the mixed solution to obtain ...

Embodiment 3

[0078] A kind of composite protein peptide hydrogel of this embodiment is prepared from the following components in terms of mass percentage:

[0079] serial number

name

content

1

Silk Fibroin Peptide

3％

2

Bovine Casein Peptides

3％

3

Sericin

0.6％

4

Additives (75% Xanthan Gum + 25% Glycerin)

2％

5

Preservative (Phenoxyethanol)

0.5％

6

water

margin

[0080] The preparation method of above-mentioned silk fibroin peptide comprises the following steps:

[0081] (1) the complete silk fibroin (silkworm cocoon shell) that has been degummed is placed in 50wt% CaCl 2 In aqueous solution (silk fibroin and CaCl 2 The mass ratio of the aqueous solution is 1:15), heated to 80°C and stirred to dissolve. After the solution is cooled, dialyze and desalt with water, and concentrate to obtain a silk fibroin solution with a concentration of 10 wt%.

[0082] (2) Adjust the pH value of the silk fib...

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Abstract

The invention relates to a composite protein peptide with skin care efficacy, a hydrogel thereof and a preparation method. The composite protein peptide comprises the following components by weight: 1.0-7.0 parts of silk fibroin peptide, 1.0-7.0 parts of casein peptide, and 0.1-2.0 parts of sericin. The composite protein peptide hydrogel comprises the following components by mass percentage: 0.5-20% of the composite protein peptide, 1.5-2.5% of an additive, 0.3-0.6% of a preservative, and the balance water, wherein the additive is one or more of xanthan gum, Carbomer, sodium alginate, and glycerin. The composite protein peptide and the hydrogel thereof provided by the invention have water supplementing, moisturizing, whitening, oxidation resisting and other skin care efficacy.

Description

technical field [0001] The invention relates to the field of skin care products, in particular to a complex protein peptide with skin care effects, its hydrogel and a preparation method. Background technique [0002] People in modern society are under a lot of pressure in all aspects, and the surrounding environment of life and work is getting worse and worse, resulting in people's skin condition is not very good, the most obvious is that the skin becomes very dry, lack of moisture, long-term In this state, the skin will become rough, long spots and so on. Moreover, with the growth of age, the collagen in human skin will gradually decrease in metabolism, and the ultraviolet rays will reach the dermis through the epidermis, which will further promote the decomposition of collagen. In the absence of collagen in the skin, the collagen fibers will be cross-linked and solidified, making the cells When the interglucose decreases, the skin loses its softness, elasticity and luster...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/65A61K8/04A61Q19/02A61Q19/08
CPCA61K8/042A61K8/64A61K8/65A61K2800/5922A61Q19/02A61Q19/08
Inventor 冯明昊霍炜强
Owner 广州中科国典环境科技有限公司
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