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Effective exocarpium part and application of effective exocarpium part to preparing of medicine for treating diabetic cardiomyopathy

A technique of turning effective parts into orange red, which is applied in the field of natural medicines to achieve the effect of reducing the content, being suitable for large-scale production, and having simple preparation steps

Inactive Publication Date: 2016-09-07
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no clinically effective treatment

Method used

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  • Effective exocarpium part and application of effective exocarpium part to preparing of medicine for treating diabetic cardiomyopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] An effective part of tangerine red, prepared by a method comprising the following steps:

[0036] S1. At first, the citrus red is extracted with ethanol with a volume fraction of 95%, to obtain an ethanol extract;

[0037] S2. Put the ethanol extract on a macroporous adsorption resin column (the amount of macroporous resin used is: 1g of dry ethanol extract, use a macroporous resin column with a column volume of 50ml), first use a volume fraction of 3 times the column volume to 25 % ethanol to remove impurities, then elute with 65% ethanol by volume fraction, and collect the ethanol elution site with 65% volume fraction;

[0038] S3. The 65% ethanol elution part obtained in step S2 is enriched with active ingredients through silica gel column chromatography to obtain the effective part of Huatangerine; the enrichment method of the silica gel column chromatography is: the ethanol prepared through step S2 The eluted part is concentrated and dried, and then put on a silic...

Embodiment 2

[0040] An effective part of tangerine red, prepared by a method comprising the following steps:

[0041] S1. At first, the citrus red is extracted with ethanol with a volume fraction of 95%, to obtain an ethanol extract;

[0042] S2. Put the ethanol extract on a macroporous adsorption resin column (the amount of macroporous resin used is: 1g of dry ethanol extract, use a macroporous resin column with a column volume of 50ml), first use a volume fraction of 3 times the column volume to 10 % ethanol to remove impurities, then elute with 70% ethanol by volume fraction, and collect the ethanol elution site with 70% volume fraction;

[0043] S3. The 70% ethanol elution part obtained in step S2 is enriched by silica gel column chromatography to obtain the active ingredient of Huatangerine; the enrichment method of the silica gel column chromatography is: the ethanol prepared by step S2 The eluted part is concentrated and dried, and then put on a silica gel column (the amount of sil...

Embodiment 3

[0045] An effective part of tangerine red, prepared by a method comprising the following steps:

[0046] S1. At first, the citrus red is extracted with ethanol with a volume fraction of 95%, to obtain an ethanol extract;

[0047] S2. Put the ethanol extract on a macroporous adsorption resin column (the amount of macroporous resin used is: 1g of dry ethanol extract, use a macroporous resin column with a column volume of 50ml), first use a volume fraction of 3 times the column volume to 30 % ethanol to remove impurities, then elute with 70% ethanol by volume fraction, and collect the ethanol elution site with 50% volume fraction;

[0048]S3. Enrich the 50% ethanol eluted part obtained in step S2 through silica gel column chromatography to enrich the active ingredient to obtain the effective part of tangerine red; The eluted part is concentrated and dried, and then put on a silica gel column (the amount of silica gel is 30 times the weight of the ethanol eluted part after drying...

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Abstract

The invention relates to the technical field of natural medicine, and particularly discloses an effective exocarpium part and an application of the effective exocarpium part to preparing of medicine for treating diabetic cardiomyopathy. A preparing method of the effective exocarpium part includes the steps that S1, extraction is carried out through an organic solvent for exocarpium, and organic solvent extract is obtained; S2, the organic solvent extract is fed to a macroreticular resin column, elution is carried out through ethyl alcohol with the volume fraction of 10% to 30% for purification, then elution is carried out through ethyl alcohol with the volume fraction of 50% to 70%, and the ethyl alcohol elution part of 50% to 70% is collected; S3, effective ingredients of the ethyl alcohol elution part of 50% to 70% obtained in the step S2 are gathered in a silica gelcolumn chromatography mode, and the effective exocarpium part is obtained. By means of the effective exocarpium part, the content of rat-myocardium NF-kappaB protein can be remarkably reduced, and the effective exocarpium part can be used for treating diabetic cardiomyopathy.

Description

technical field [0001] The invention relates to the technical field of natural medicines, in particular to an effective fraction of citrus red and its application in the preparation of medicines for treating diabetic cardiomyopathy. Background technique [0002] Diabetes is a common metabolic disorder that seriously threatens human life. The latest research shows that there are as many as 92.4 million diabetic patients in China, and 148 million pre-diabetic patients. Cardiovascular disease is the main cause of death for diabetic patients. Epidemiological studies have confirmed that more than 70% of diabetic patients die of cardiovascular disease. It is 2-3 times the mortality rate of cardiovascular system diseases in non-diabetic population. Among them, diabetic cardiomyopathy (diabetic cardiomyopathy, DCM) is one of the independent complications of diabetes, which has a high incidence and high risk, and is closely related to the high incidence and high mortality of cardiov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P3/10A61P9/00
CPCA61K36/752A61K2236/33A61K2236/55
Inventor 吴铿郭润民游琼莫海亮黄瑞娜吴子君刘畅姜佳美
Owner GUANGDONG MEDICAL UNIV
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