Effective exocarpium part and application of effective exocarpium part to preparing of medicine for treating diabetic cardiomyopathy

A technique of turning effective parts into orange red, which is applied in the field of natural medicines to achieve the effect of reducing the content, being suitable for large-scale production, and having simple preparation steps
CN105920152AInactive Publication Date: 2016-09-07GUANGDONG MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG MEDICAL UNIV
Publication Date
2016-09-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of natural medicine, and particularly discloses an effective exocarpium part and an application of the effective exocarpium part to preparing of medicine for treating diabetic cardiomyopathy. A preparing method of the effective exocarpium part includes the steps that S1, extraction is carried out through an organic solvent for exocarpium, and organic solvent extract is obtained; S2, the organic solvent extract is fed to a macroreticular resin column, elution is carried out through ethyl alcohol with the volume fraction of 10% to 30% for purification, then elution is carried out through ethyl alcohol with the volume fraction of 50% to 70%, and the ethyl alcohol elution part of 50% to 70% is collected; S3, effective ingredients of the ethyl alcohol elution part of 50% to 70% obtained in the step S2 are gathered in a silica gelcolumn chromatography mode, and the effective exocarpium part is obtained. By means of the effective exocarpium part, the content of rat-myocardium NF-kappaB protein can be remarkably reduced, and the effective exocarpium part can be used for treating diabetic cardiomyopathy.
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Description

technical field

[0001] The invention relates to the technical field of natural medicines, in particular to an effective fraction of citrus red and its application in the preparation of medicines for treating diabetic cardiomyopathy. Background technique

[0002] Diabetes is a common metabolic disorder that seriously threatens human life. The latest research shows that there are as many as 92.4 million diabetic patients in China, and 148 million pre-diabetic patients. Cardiovascular disease is the main cause of death for diabetic patients. Epidemiological studies have confirmed that more than 70% of diabetic patients die of cardiovascular disease. It is 2-3 times the mortality rate of cardiovascular system diseases in non-diabetic population. Among them, diabetic cardiomyopathy (diabetic cardiomyopathy, DCM) is one of the independent complications of diabetes, which has a high incidence and high risk, and is closely related to the high incidence and high mortality of cardiov...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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