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Immune cell preserving fluid

A technology of immune cells and preservation solution, applied in the field of cell culture, can solve the problems of decreased cell activity, simple components, affecting the treatment effect, etc., and achieve the effect of good cell activity

Inactive Publication Date: 2016-09-14
GUANGZHOU ZISHENG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing immune cell preservation solution has simple components and can only be used for short-term preservation or low-temperature preservation of cells. Under normal temperature conditions, cell activity decreases rapidly, which seriously affects the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] An immune cell preservation solution, including the following components: recombinant human interleukin-2 20 U / mL; human serum albumin 5 mg / mL; α-1,4-glucan 0.5 mg / mL; glucose 0.5 mg / mL ; Sodium citrate 3.5 mg / mL; Sodium gluconate 3.5 mg / mL; Potassium chloride 0.25 mg / mL; Magnesium chloride 0.35 mg / mL.

Embodiment 2

[0013] An immune cell preservation solution, including the following components: recombinant human interleukin-2 10 U / mL; human serum albumin 2 mg / mL; α-1,4-glucan 1.5 mg / mL; glucose 1.0 mg / mL ; Sodium citrate 3.5 mg / mL; Sodium gluconate 2.0 mg / mL; Potassium chloride 0.35 mg / mL; Magnesium chloride 0.25 mg / mL.

Embodiment 3

[0015] An immune cell preservation solution, including the following components: recombinant human interleukin-2 50 U / mL; human albumin 10 mg / mL; α-1,4-glucan 0.5 mg / mL; glucose 0.5 mg / mL ; Sodium citrate 5.0 mg / mL; Sodium gluconate 2.0 mg / mL; Potassium chloride 0.5 mg / mL; Magnesium chloride 0.5 mg / mL.

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PUM

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Abstract

The invention discloses immune cell preserving fluid. The immune cell preserving fluid comprises 0-50 U / mL of recombinant human interleukin-2, 0-10 mg / mL of human albumin, 0-1.5 mg / mL of alpha-1,4-glucan, 0.5-2.0 mg / mL of glucose, 3.5-5.0 mg / mL of sodium citrate, 2.0-3.5 mg / mL of sodium gluconate, 0.2-0.5 mg / mL of potassium chloride and 0.2-0.5 mg / mL of magnesium chloride. The immune cell preserving fluid has the advantages of being suitable for cell preservation within a wide temperature range, and capable of guaranteeing high cell viability of immune cells and facilitating follow-up cell experiment or clinical treatment.

Description

technical field [0001] The invention belongs to the technical field of cell culture, in particular to an immune cell preservation solution. Background technique [0002] Immune cell therapy is a new type of autoimmune anti-cancer treatment. It uses biotechnology and biological agents to culture and amplify immune cells collected from patients in vitro and then infuse them back into patients to stimulate and enhance immunity. Improve the immune function of the body, so as to achieve the purpose of treating tumors. Cell activity has a very important impact on the therapeutic effect, and how to maintain good cell activity during cell transportation is particularly important. The existing immune cell preservation solution has simple components and can only be used for short-term preservation or low-temperature preservation of cells. Under normal temperature conditions, the cell activity decreases rapidly, which seriously affects the therapeutic effect. Contents of the inventi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/021
Inventor 陈祥阮雯莉
Owner GUANGZHOU ZISHENG BIOLOGICAL TECH CO LTD