Thermal management in the context of automated histological processing of biological specimens and associated technology

A technique for specimens, tissues, applied in chemical instruments and methods, heating or cooling equipment, preparation of samples for testing, etc., which can solve problems such as slowness and do not allow control of staining characteristics

Active Publication Date: 2016-09-28
VENTANA MEDICAL SYST INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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  • Thermal management in the context of automated histological processing of biological specimens and associated technology
  • Thermal management in the context of automated histological processing of biological specimens and associated technology
  • Thermal management in the context of automated histological processing of biological specimens and associated technology

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Embodiment Construction

[0119] It is often desirable to increase the consistency and controllability of certain attributes (eg, staining intensity) of tissue-processed specimens. Treatment time (ie, the duration of a given tissue treatment) and treatment temperature (ie, the temperature at which a given tissue treatment is performed) are two variables that affect most, if not all, of these attributes. Automated organizational systems configured in accordance with at least some embodiments of the present technology include features that facilitate consistency and / or controllability of processing times and / or processing temperatures. For example, at least some of these systems include a stainer having a processing head capable of precisely performing controlled liquid dispensing and removal operations. These dyers can also have an internal environment that can be maintained at an elevated baseline temperature. It is expected that the performance (eg, with respect to quality and / or versatility) of thes...

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Abstract

Methods and system capable of processing specimens carried by slides within an automated histological staining system. A slide carrier is moved toward and into a temperature-controlled internal environment of a stainer within the system. The slide carrier carries a first slide and a second slide, and the first and second slides can carry a first specimen and a second specimen, respectively. The first and second specimens are stained with at least one of a staining reagent and a counterstaining reagent while the first and second slides are within the internal environment and while an average temperature of the internal environment is greater than ambient temperature. The slide carrier can be moved out of the internal environment after staining one or both specimens.

Description

technical field [0001] The present technology generally relates to automated tissue processing of biological specimens (eg, tissue samples), such as systems, devices, methods and compositions that enhance the quality, precision, efficiency, and / or other aspects of such processing. Background technique [0002] A wide variety of techniques can be used to analyze biological samples. Examples of analytical techniques useful in this context include microscopy, microarray analysis (eg, protein and nucleic acid microarray analysis), and mass spectrometry. Preparation of specimens for these and other types of analysis typically involves contacting the specimen with a series of processing fluids. Some of these processing fluids (eg, staining reagents and contrasting staining reagents) can increase color and contrast or otherwise alter invisible or poorly visible specimen components (eg, at least some types of cells and intracellular structures) visual characteristics. Other proce...

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Application Information

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IPC IPC(8): G01N1/31
CPCG01N1/312G01N2035/00376G01N1/2813G01N35/1002B01L7/52B01L2300/0822B01L2300/1844G01N1/30G01N35/00029G01N35/00722G01N35/0099G01N2001/302G01N2035/00039G01N2035/00138G01N2035/00306G01N2035/00356G01N2035/0091
Inventor T.凯勒M.梅特C.谢G.沃德C.威尔金森
Owner VENTANA MEDICAL SYST INC
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