A Multi-Echo Phase Fitting Method for Magnetic Resonance Quantitative Susceptibility Imaging
A quantitative magnetic susceptibility and magnetic resonance technology, applied in diagnostic recording/measurement, medical science, diagnosis, etc., can solve problems such as large noise, low signal-to-noise ratio of magnetic susceptibility distribution map, and reduced signal-to-noise ratio of magnetic susceptibility distribution map. Achieve the effect of improved signal-to-noise ratio, accurate magnetic susceptibility value, and obvious tissue contrast
Active Publication Date: 2018-09-28
EAST CHINA NORMAL UNIV
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Therefore, for these nuclei, all the echoes are used to fit the noise signal into the local magnetic field, which reduces the signal-to-noise ratio of the magnetic susceptibility distribution map.
The magnetic field distribution map obtained by the conventional weighted least squares method is noisy in the skull base and other parts, resulting in a low signal-to-noise ratio of the final magnetic susceptibility distribution map, which cannot accurately measure the magnetic susceptibility value of the skull base tissue
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[0037] The present invention will be described in further detail in conjunction with the following specific embodiments and accompanying drawings. The process of implementing the present invention, conditions, experimental scheme methods, etc., except the content specifically mentioned below, are common knowledge and common knowledge in the art, and the present invention has no special limitation content.
[0038] The multi-echo phase fitting method for quantitative magnetic susceptibility of the present invention introduces a threshold cut-off condition before fitting with a conventional weighted least square method. According to the degree of signal attenuation of different tissues, the number of echoes is reasonably selected, the echoes whose amplitude is lower than the predetermined threshold are cut off, and only the echoes whose amplitude is higher than or equal to the predetermined threshold are allowed to participate in phase fitting, so as to reduce the number of multi...
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The invention discloses a magnetic resonance quantitative magnetic susceptibility imaging multi-echo phase fitting method, which comprises the steps of obtaining magnetic resonance original data through multi-echo gradient echo sequence acquisition; obtaining noise intensity level by calculating tested first echo pattern noise; arranging a threshold for cross cutting a signal according to a pattern noise level; selectively cross cutting the magnetic resonance multi-echo signal, cross cutting echo whose signal amplitude is lower than the threshold, and only allowing echo whose signal amplitude is higher than or equal to the threshold participate phase fitting; obtaining a magnetic field distribution map by performing phase fitting to echo that satisfies the threshold by employing weight least spuares; and performing subsequent processing like time-domain unwinding and background field removing to the magnetic field distribution map. In this way, a magnetic susceptibility distribution map is retrieved from the field to the source. The magnetic resonance quantitative magnetic susceptibility imaging multi-echo phase fitting method has the advantages like rapid and accurate.
Description
technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a multi-echo phase fitting method for quantitative magnetic susceptibility imaging. Background technique [0002] Quantitative magnetic susceptibility imaging uses the phase information discarded by general magnetic resonance imaging technology to obtain the local magnetic field variation characteristics, and then through the complex field-to-source inversion calculation, the quantitative magnetic susceptibility distribution map can be directly obtained. Single-echo or multi-echo gradient-echo sequences can be used to obtain the magnetic field profile needed for susceptibility profile inversion calculations. Compared with the single-echo gradient echo sequence, the multi-echo sequence can collect multiple echoes in one excitation, which is conducive to phase unwrapping, and is more sensitive to the magnetic susceptibility, and the obtained magnetic susceptibili...
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IPC IPC(8): A61B5/055A61B5/00
CPCA61B5/055A61B5/72
Inventor 赵欣欣李建奇薄斌仕王乙
Owner EAST CHINA NORMAL UNIV