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A kind of compound cortex phellodendri liquid enema for treating colorectal inflammation and its preparation method

A technology of compound Phellodendron phellodendron liquid and compound Phellodendron phellodendron, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problems that the curative effect cannot be fully exerted, the bioavailability is reduced, and the drug retention time is short. To achieve good skin tolerance, high bioavailability, safety and tolerance

Active Publication Date: 2019-10-15
SHANDONG HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical dosage form of Compound Phellodendron Phellodendron Liquid Paint is mainly liquid preparation for external use. Clinically, liquid dosage form enema is used to treat colorectal inflammation, so that the drug stays in the lesion for a short time, and the curative effect cannot be fully exerted, and some precipitation will occur after long-term storage Precipitation, resulting in reduced efficacy and reduced bioavailability

Method used

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  • A kind of compound cortex phellodendri liquid enema for treating colorectal inflammation and its preparation method
  • A kind of compound cortex phellodendri liquid enema for treating colorectal inflammation and its preparation method
  • A kind of compound cortex phellodendri liquid enema for treating colorectal inflammation and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The development of embodiment 1 compound phellodendron liquid enema

[0030] (1) Materials and methods

[0031] 1.1 Instrument

[0032] Electric heating mantle, rotary evaporator, refrigerator, oven, electronic balance, magnetic stirrer, etc.

[0033] 1.2 Materials and reagents

[0034] Forsythia: the dry fruit of Forsythia suspensa (Thunb.) Vahl, a plant of Oleaceae.

[0035] Phellodendron chinense: the dry bark of Phellodendron chinense Schneid.

[0036] Honeysuckle: It is the dry flower bud or the first flower of Lonicera japonica Thunb.

[0037] Dandelion: It is the dried whole herb of Taraxacum mongolicum Hand.-Mazz., Taraxacum borealisinense Kitam. or several plants of the same genus.

[0038] Centipede: It is the dry body of Scolopendra subspinipes mutilans L. Koch, a centipede animal with few spines.

[0039] The above-mentioned medicinal materials are in compliance with the provisions of each medicinal material in the first part of the "Chinese Pharmacopo...

Embodiment 2

[0110] Preliminary Pharmacodynamic Test of Example 2 Compound Cortex Phellodendri Liquid Enema

[0111] The compound Phellodendron Phellodendri thermosensitive gel prepared above was tested on the rat ulcerative colitis animal model, and the specific experiments were as follows:

[0112] Grouping of test animals: male rats weighing 180g to 220g were randomly divided into blank control group, model control group and compound Phellodendron thermosensitive gel group.

[0113]Ulcerative colitis model preparation and administration: 10 rats were randomly selected as the blank control group, and the rest of the rats were fasted for 24 hours, anesthetized, and prepared trinitrobenzenesulfonic acid (TNBS) ethanol solution (ethanol concentration 33 %), mix well, use a special silicone tube to introduce it into the colon of rats about 8cm away from the anus, perfuse about 1ml of solution for each rat for the first time, if there is overflow, add 0.2-0.3ml (containing TNBS20mg ~30mg), t...

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Abstract

The invention discloses a compound cortex phellodendri fluid enema for treating coloproctitis. The compound cortex phellodendri fluid enema is prepared from the following raw materials and auxiliary materials in percentage by weight: 5% of compound cortex phellodendri fluid extract, 17-21 % of poloxamer 407, 2-4 % of poloxamer 188, 3-10 % of Transcutol P, 0-0.2 % of a preservative, and the balance of water. A preparation method comprises the following steps: adding poloxamer 407, poloxamer 188, Transcutol P, the preservative and water into the compound cortex phellodendri fluid extract, uniformly stirring the materials, and placing the obtained solution at 4 DEG C till the obtained solution is in the form of semitransparent solution capable of freely flowing, thus obtaining the compound cortex phellodendri fluid enema. The compound cortex phellodendri fluid enema treats coloproctitis through the rectal administration manner, and has the advantages of being rapid in taking effect, high in bioavailability, convenient and safe to use, etc.

Description

technical field [0001] The invention relates to a compound phellodendron liquid enema for treating colorectal inflammation and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] In today's society, with the improvement of people's living standards, great changes have taken place in diet structure and living habits, and the incidence of colorectal diseases is also increasing year by year. The incidence of colorectal cancer has become the third leading cause of malignant tumors. bit. Colorectitis is a digestive tract disease characterized by chronic diffuse inflammation of the colon and rectal mucosa. , impaired liver function, thromboembolism, cardiomyopathy and other extraintestinal manifestations and systemic manifestations such as hypoproteinemia, fever, electrolyte imbalance, etc., the course of the disease is protracted and the recurrence rate is high. At present, due to the lack of specific meas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61K9/06A61K47/10A61K47/12A61P1/00A61K35/648
Inventor 秦承雪
Owner SHANDONG HANFANG PHARMA