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Application of hemp extract in preparation of medicine for treating gouty arthritis

A gouty arthritis and extract technology, which is applied to the application field of cannabis extract in the preparation of gouty arthritis medicines, can solve the problems of large side effects, prone to gastrointestinal symptoms, bone marrow suppression, etc., and achieves a reduction in creatinine. , the prevention and treatment of hyperuricemia, the effect of regulating the body's cytokines

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, colchicine, a specific drug for the clinical treatment of acute gouty arthritis, has relatively large side effects, and is prone to adverse reactions such as gastrointestinal symptoms and bone marrow suppression. Therefore, it is urgent to develop a drug with specific effects and relatively small side effects

Method used

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  • Application of hemp extract in preparation of medicine for treating gouty arthritis
  • Application of hemp extract in preparation of medicine for treating gouty arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take the mixture of cannabis flowers, leaves and hemp bran, remove impurities, dry and crush, then extract with CO2 ultra-superior, dissolve in methanol after removing impurities, and elute the solution with hexane after separation by chromatography column, collect the eluate , concentrated under reduced pressure, dried in vacuo, and pulverized to obtain tetrahydrocannabinol. Take cannabis flowers and leaves, after impurity removal, drying, and crushing, CO2 super-extraction, ethanol redissolution after impurity removal, pentane elution of the solution after chromatographic separation, collection of eluent, concentration under reduced pressure, vacuum Dried and pulverized to obtain cannabidiol.

[0035] Tetrahydrocannabinol and cannabidiol are mixed according to the weight ratio of 4:1 to 1:4 to prepare the required cannabis extract.

[0036] Get 100 grams of hemp extract (through 80 mesh sieve), add 60 grams of microcrystalline cellulose, pass through 80 mesh sieve th...

Embodiment 2

[0038] Take cannabis flowers and leaves, remove impurities, dry and crush, then extract with CO2, dissolve in methanol after removing impurities, separate the solution through a chromatographic column, and then elute with hexane, collect the eluate, concentrate under reduced pressure, Vacuum-dried and pulverized to obtain tetrahydrocannabinol. Take the mixture of cannabis flowers, leaves, and hemp bran, remove impurities, dry, and pulverize, then extract with CO2, and redissolve in ethanol after removing impurities. The solution is separated by chromatography and eluted with pentane. Concentrate under reduced pressure, dry in vacuum, and pulverize to obtain cannabidiol.

[0039] Tetrahydrocannabinol and cannabidiol are mixed according to the weight ratio of 4:1 to 1:4 to prepare the required cannabis extract.

[0040] The hemp extract powder is taken, 5-20% of dry starch and 1-5% of magnesium stearate are added, mixed, granulated, dried and compressed to obtain tablets.

Embodiment 3

[0042] Repeat Example 2, with the following differences: get the hemp extract powder, add sucrose water and conventional amounts of preservatives, stabilizers and other auxiliary materials. Filter, sterilize, and divide into 10mL bottles to make oral liquid.

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Abstract

The invention discloses application of hemp extract in preparation of medicine for treating gouty arthritis. An inventor finds that after tetrahydrocannabinol and cannabidiol are mixed according to a specific ratio, the effects of remarkably reducing creatinine and uric acid in hyperuricemia mouse serum and preventing hyperuricemia are achieved for the first time. Meanwhile, organism cell factors are adjusted, inflammation is effectively resisted, gouty arthritis symptoms are relieved, and treatment and prevention effects are achieved for gouty arthritis. The invention further provides a pharmaceutical preparation of the hemp extract for treating gouty arthritis and a dosage form corresponding to the pharmaceutical preparation. The medicine which is used clinically and has various different dosage forms can be prepared through a conventional preparation method, and use is convenient.

Description

technical field [0001] The invention relates to the new application of cannabis in medicine, in particular to the application of a cannabis extract in the preparation of medicine for treating gouty arthritis. Background technique [0002] Gouty arthritis is a class of diseases caused by purine metabolism disorders in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion is decreased, which can cause hyperuricemia. ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/05A61P19/06A61P19/02
CPCA61K31/352A01N65/08A61K31/05A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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