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Kudzu vine root particles and traditional Chinese medicine preparation thereof

A granule and pueraria technology, applied in the field of pueraria granules and its traditional Chinese medicine preparations, can solve problems such as inability to analyze multiple varieties and batches of samples in real time, physical damage to inspectors, and lag in information feedback, and achieve process parameters that are easy to control and accurate. High performance and stable process parameters

Active Publication Date: 2016-11-09
浙江一方制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of water and ethanol extracts in pueraria granules requires several hours by referring to the pharmacopoeia, and the operation is more complicated.
The main chemical component of Pueraria granules is puerarin, which is used as a quality control indicator. The traditional method uses high-performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a lot of reagents, and pollutes the environment and inspectors. The body is damaged, and the information feedback is lagging behind, which cannot meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • Kudzu vine root particles and traditional Chinese medicine preparation thereof
  • Kudzu vine root particles and traditional Chinese medicine preparation thereof
  • Kudzu vine root particles and traditional Chinese medicine preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of kudzu root granules: take kudzu root decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, and heat and decoct for 1.5 hours each time; the medicinal liquids are combined, and the filtrate is concentrated to a clear paste with a relative density of 1.08 (80°C). Filtrate with a 350-mesh sieve while it is hot; spray dry under the conditions of air inlet temperature 160°C, material pump speed 400 rpm, outlet air temperature 90°C, and air supply temperature 45°C to obtain spray-dried powder; Aperture diameter 1.50mm, roll motor frequency 40HZ, feeding motor frequency 50HZ, oil cylinder pressure 18bar under the conditions of dry granulation to obtain Pueraria granules with a particle size of 40 mesh.

Embodiment 2

[0036] Preparation of traditional Chinese medicine preparation containing Pueraria granules: take Pueraria decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, and heat and decoct for 1.5 hours each time; the medicinal liquids are combined, and the filtrate is concentrated to a relative density of 1.08 (80°C) The clear paste is filtered with a 350-mesh sieve while it is hot; it is spray-dried under the conditions of an inlet air temperature of 160°C, a material pump speed of 400 rpm, an outlet air temperature of 90°C, and an air delivery temperature of 45°C to obtain a spray-dried powder; Dry granulation under the conditions of punching plate aperture 1.50mm, roller motor frequency 40HZ, feeding motor frequency 50HZ, oil cylinder pressure 18bar, to obtain Pueraria granules with a particle size of 40 mesh; mix 170g of Pueraria granules with 65g of maltodextrin, add appropriate amount of Magnesium fatty acid, mixed evenly, pressed into 1000 ta...

Embodiment 3

[0038] A method for rapidly detecting the moisture content of kudzu root granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0039] a. Take pueraria granule samples, a total of 88 batches, about 3g each, grind into fine powder, put into a stoppered glass sample bottle, place on a near-infrared scanner to scan, collect spectra, scan conditions: scan range 4000 -12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum figure of 88 batches of kudzu root particles shown;

[0040] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was measured by the drying method, and about 2 g of kudzu root particles that were ground into fine powder were spread flat in a flat wei...

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Abstract

The invention discloses kudzu vine root particles and a traditional Chinese medicine preparation thereof. The kudzu vine root particles are prepared through a method comprising the following steps that kudzu vine root decoction pieces are taken, water is added for decoction 2-3 times, 5-10-fold water is added every time, and heating is carried out for decoction for 1-2 hours; the medicine liquid is combined, filtrate is concentrated into clear paste with the relative density being 1.02 to 1.10, and filtering is carried out with a screen of 250-350 mesh while the clear paste is hot; the clear paste is taken for spray drying, and spray-dried powder is obtained; the spray-dried powder is subjected to dry granulating, and the kudzu vine root particles with the particle size being 16-40 mesh are obtained. The preparation process of the kudzu vine root particles is simple, technological parameters are easy to control, and a scientific, fast and high-operability detecting method is achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to Pueraria granules and traditional Chinese medicine preparations. Background technique [0002] Pueraria lobata (Willd.) Ohwi is derived from the dry root of Pueraria lobata (Willd.) Ohwi, a leguminous plant. It is sweet, pungent, and cool, and returns to the spleen, stomach, and lung meridians. , dredging the meridians and activating collaterals, the effect of detoxification. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and treatment, addition and subtraction according to the syn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/16G01N21/359G01N21/3563
CPCA61K9/16A61K36/488A61K2236/331A61K2236/39A61K2236/51G01N21/3563G01N21/359G01N2021/3572
Inventor 王闽予朱德全霍文杰刘丽萍陈向东谭登平程学仁
Owner 浙江一方制药有限公司
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