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Marker used for detecting laryngocarcinoma and purpose thereof

A marker, laryngeal cancer technology, applied in the field of laryngeal cancer markers

Inactive Publication Date: 2016-11-09
上海阿趣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are few reports on metabolomics research on laryngeal cancer and hypopharyngeal cancer at home and abroad, and there are no specific markers available for early diagnosis, treatment and prognosis monitoring of laryngeal cancer for clinical application

Method used

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  • Marker used for detecting laryngocarcinoma and purpose thereof
  • Marker used for detecting laryngocarcinoma and purpose thereof
  • Marker used for detecting laryngocarcinoma and purpose thereof

Examples

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Embodiment Construction

[0036] The present invention is based at least in part on the discovery of markers associated with the development of laryngeal cancer and the response to treatment in subjects with laryngeal cancer. Therefore, the present invention provides methods and kits for predicting whether a subject has or will develop laryngeal cancer by measuring and identifying specific markers or a specific combination of markers, as well as methods and kits for identifying compounds that can slow the progression of laryngeal cancer. A method of compound, a method of monitoring the efficacy of a therapy in reducing the progression of laryngeal cancer in a subject.

[0037] Accordingly, in one aspect, the invention provides markers for determining whether a subject has or will develop laryngeal cancer: creatine, 1,3-diaminopropane, thymine, 3-aminoisobutyric acid, cytidylic acid , Putrescine.

[0038] In another aspect, the invention provides methods for inhibiting the development of laryngeal canc...

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Abstract

The invention provides a marker used for detecting whether a subject gets laryngocarcinoma or not, or has a trend to laryngocarcinoma, and the marker comprises one or more of creatine, 1,3-diaminopropanes, thymidine, 3-aminoisobutyric acid, cytidylic acid and putrescine, diagnosis sensitivity can reach 93.33%, and specificity is 0%.

Description

technical field [0001] The present invention relates to a laryngeal cancer marker, especially G01N33 / 68. Background technique [0002] In recent years, due to the combined effect of various carcinogenic factors such as the environment, the incidence of laryngeal cancer has gradually increased. Although comprehensive treatment measures based on surgery have made great progress, the 5-year survival rate of patients with laryngeal cancer has not improved significantly after comprehensive treatment. Nevertheless, a large number of clinical data show that the time of treatment has an important impact on the prognosis of patients. However, due to the relatively hidden location of laryngeal cancer, there are often no obvious symptoms in the early stage, and early diagnosis is difficult. At present, there is no reliable specific index for early diagnosis. Sexual tumor markers to assist early diagnosis. [0003] Previous foreign studies focused on head and neck cancer (tumors of a...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N33/574
CPCG01N30/02G01N33/57484G01N2030/025G01N2030/027
Inventor 楼格尔邓军亮吴洪强
Owner 上海阿趣生物科技有限公司
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