Carbocisteine syrup and preparation method thereof

A technology of carbocisteine ​​and syrup, which is applied in the field of carbocisteine ​​syrup and its preparation, which can solve the problems of troublesome taking, cumbersome process, and difficulty in covering the bad taste of the drug, and achieves low cost, simple process, and easy industrialization The effect of production

Inactive Publication Date: 2016-11-16
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The cough-relieving and phlegm-reducing drugs currently on the market are mainly ordinary solid preparations (such as tablets, gr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) Weigh 450g sucrose, add 450ml purified water, boil to dissolve, filter, let cool to 50℃;

[0015] (2) Weigh 25g of the raw drug carbocisteine, add it to 200ml of water, slowly add about 120ml of sodium hydroxide solution under stirring (dissolve 5.6g of sodium hydroxide in 120ml of water to obtain a sodium hydroxide solution), and make carboxymethylsteine Stein is completely dissolved (alkali is added at a molar ratio of 1:1 to form a salt), an appropriate amount of methyl hydroxybenzoate 1g, vanillin 0.5g, and cherry flavor essence 0.5g are added, and fully stirred;

[0016] (3) Add the solution in (2) to the syrup mentioned in (1); make the relative density of the liquid medicine 1.08-1.25; add an appropriate amount of boiling water to 1L, stir well, and wait for the temperature of the liquid medicine to cool below 50°C and pass the test After filtering, the filtrate is an antitussive and expectorant syrup.

Embodiment 2

[0018] (1) Weigh 500g sucrose, add 500ml purified water, boil to dissolve, filter, let cool to 50℃;

[0019] (2) Weigh 50g of the raw drug carbocisteine, add it to 200ml of water, slowly add about 250ml of sodium hydroxide solution under stirring (dissolve 11.2g of sodium hydroxide in 250ml of water to obtain a sodium hydroxide solution), and make carboxymethylsteine Stein is completely dissolved (add alkali to form a salt at a molar ratio of 1:1), add an appropriate amount of methyl hydroxybenzoate 1g, vanillin 1g, and cherry flavor essence 1g, and stir thoroughly;

[0020] (3) Add the solution in (2) to the syrup described in (1); make the relative density of the liquid medicine 1.08-1.25; add an appropriate amount of boiling water to 1L, stir well, and pass the test when the temperature of the liquid medicine is cooled to below 50°C After filtering, the filtrate is an antitussive and expectorant syrup.

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PUM

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Abstract

The invention relates to carbocisteine syrup with improved water solubility and a preparation method of the carbocisteine syrup. The method comprises the following steps: weighing syrup substrate, adding an appropriate amount of purified water into the syrup substrate, carrying out complete boiling so that the syrup substrate is dissolved, carrying out filtering, carrying out standing for cooling till the temperature is 40-60 DEG C, and carrying out shaking till the product is uniform, thus obtaining simple syrup; weighing an active pharmaceutical ingredient, namely, carbocisteine, adding carbocisteine into an appropriate amount of water, slowly adding with an appropriate amount of sodium hydroxide solution under stirring, so that carbocisteine is completely dissolved (alkali is added according to the molar ratio of 1 to 1 for forming salt), adding with an appropriate amount of a preservative and an appropriate amount of a corrigent, and carrying out sufficient stirring; adding the carbocisteine solution into the simple syrup; enabling the relative density of the liquid medicine to be 1.08-1.25; adding with an appropriate amount of boiling water, carrying out stirring till the uniform state is reached, and carrying out filtering after the assay was approved after the liquid medicine is cooled to be 50 DEG C or below, and thus obtaining the filtrate, which is the syrup capable of relieving cough and eliminating phlegm. The method provided by the invention is simple in process and low in cost, the obtained carbocisteine syrup is good in water solubility, the method is suitable for industrial production, and thus the difficulties that carbocisteine has difficulty in dissolving in water, and the bioavailability is low are solved.

Description

technical field [0001] The invention relates to carbocisteine, in particular to a carbocisteine ​​syrup with improved water solubility and a preparation method thereof. Background technique [0002] Among the deaths caused by various diseases in my country, the deaths caused by respiratory diseases occupy the first place, and the number is still increasing year by year. In the process of urbanization, the environment is deteriorating day by day. In addition to industrial pollution, harmful gases emitted by motor vehicles seriously threaten our respiratory health, and may even induce the onset and development of other latent diseases, such as pneumonia and chronic pharyngitis. , chronic bronchitis, bronchiectasis, lung abscess and cavitary tuberculosis. At this time, in addition to prescribing the right medicine for respiratory diseases, it is also necessary to apply antitussive and expectorant drugs appropriately to relieve cough. [0003] The current application of antitu...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/198A61K47/26A61K47/10A61K47/02A61P11/14A61P11/10
CPCA61K47/02A61K31/198
Inventor 冷志爽马莉
Owner BEIJING VENTUREPHARM BIOTECH
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