Method and device for soft capsule micro-jet type micro-needle transdermal delivery

Abstract

The invention relates to the technical field of micro-needle transdermal delivery, in particular to a method and a device for soft capsule micro-jet type micro-needle transdermal delivery. The drug deliver device comprises a soft capsule which is used for storing medicine liquid, a micro-jet micro-needle unit which is capable of undergoing mechanical reciprocating vibration, a fixing unit and a controller, wherein one side of the soft capsule is bonded with and connected to a membrane of the micro-jet micro-needle unit and the other side of the soft capsule is bonded with and connected to the fixing unit; the micro-jet micro-needle unit is connected to the controller by virtue of a signal line; and the controller is used for controlling a delivery dosage of the medicine liquid and for controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each drug delivery. With the implementation of the method disclosed by the invention, by precisely controlling the drug delivery dosage and by controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each drug delivery, various pores can generate in skin cuticula, which is conducive to the medicine liquid to permeate skin epidermis; and in addition, the device disclosed by the invention can achieve change the medicine liquid safely without pollution, and the device is simple and convenient to operate and use.

Description

technical field [0001] The invention relates to the technical field of microneedle transdermal drug delivery, in particular to a method and device for soft capsule micro-spray microneedle transdermal drug delivery. Background technique [0002] Microneedle, a micron-sized hollow or solid needle similar to an injection needle, is made of single crystal silicon material, metal or polymer, with a diameter of 30-80 μm and a length of 100-1000 μm. It can just pass through the stratum corneum without touching the pain-sensing nerve, and it can promote penetration without causing pain and skin damage. In recent years, microneedle drug delivery has attracted more and more attention. [0003] At present, there are still some disadvantages of microneedle devices: [0004] One of the disadvantages is that the active drug is smeared on the surface of the microneedle of the microneedle device, and the microneedle only wraps a small amount of drug. When puncturing the skin for administr...

AI Technical Summary

Problems solved by technology

[0007] One of the disadvantages is that the drug needs to be sealed into the storage cavity in advance, and the drug solution needs to be transported from the storage cavity to the transdermal drug delivery device through the catheter to achieve transdermal drug delivery. Serious drug errors;

[0008] The second disadvantage is that the dosage of the drug is realized by the volume compression of the storage chamber, and the metering accuracy is not high;

[0009] The third disadvantage is that the storage chamber is used for one-time use, and the replacement and installation are complicated when the medicine is used up;

[0010] Disadvantage 4, long-term subcutaneous needle injection, pain and discomfort

[0011] The fifth disadvantage is that there is no drug delivery device, it is only a device for assisting drug transdermal, and cannot be used independently

[0012] The sixth disadvantage is that there is no wearable fixed unit, and the dosage and time of administration cannot be set according to the doctor's advice

Images