Method and device for soft capsule micro-jet type micro-needle transdermal delivery

A transdermal drug delivery and micro-spray technology, which is applied in the direction of microneedles, drug devices, drug devices, etc., can solve the problems that cannot be used independently, the catheter is thick and clumsy, and there is no drug delivery device, etc., so as to achieve simple operation and use Convenient, safe and pollution-free replacement, and the effect of increasing drug compliance

Inactive Publication Date: 2016-11-16
唐晨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] One of the disadvantages is that the drug needs to be sealed into the storage cavity in advance, and the drug solution needs to be transported from the storage cavity to the transdermal drug delivery device through the catheter to achieve transdermal drug delivery. Serious drug errors;
[0008] The second disadvantage is that the dosage of the drug is realized by the volume compression of the storage chamber, and the metering accuracy is not high;
[0009] The third disadvantage is that the storage chamber is used for one-time use, and the replacement and installation are complicated when the medicine is used up;
[0010] Disadvantage 4, long-term subcutaneous needle injection, pain and discomfort
[0011] The fifth disadvantage is that there is no drug delivery device, it is only a device for assisting drug transdermal, and cannot be used independently
[0012] The sixth disadvantage is that there is no wearable fixed unit, and the dosage and time of administration cannot be set according to the doctor's advice

Method used

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  • Method and device for soft capsule micro-jet type micro-needle transdermal delivery
  • Method and device for soft capsule micro-jet type micro-needle transdermal delivery
  • Method and device for soft capsule micro-jet type micro-needle transdermal delivery

Examples

Experimental program
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Effect test

Embodiment 1

[0049] A soft capsule micro-spray type micro-needle transdermal drug delivery device, such as Figure 1-3As shown, the drug delivery device includes a soft capsule 1 for storing medicinal liquid, a micro-spray microneedle unit 2 capable of mechanically reciprocating vibration in contact with the skin, a fixing unit 3 and a controller 4; one part of the soft capsule 1 One side is adhesively connected with the diaphragm 11 of the microspray microneedle unit 2, the other side of the soft capsule 1 is adhesively connected with the fixing unit 3, and the microspray microneedle unit 2 is connected to The controller 4 is connected, and the controller 4 is used for controlling the dosage of the medicinal liquid and controlling the mechanical reciprocating vibration of the microspray and microneedle unit 2 before each administration. Before each administration, the controller can control the reciprocating vibration of the microneedle, so that many micropores are formed in the stratum c...

Embodiment 2

[0059] A method for soft capsule microspray type microneedle transdermal drug delivery, said method of administration adopts a kind of soft capsule microspray type microneedle transdermal drug delivery device described in Example 1 ( figure 1 shown), the method includes the following steps:

[0060] Step 1: Firstly, the medicinal liquid is stored in the soft capsule 1 through the soft valve 7, and the medicinal liquid in the soft capsule 1 can directly contact with the position where the micropore 13 is set on the diaphragm 11 of the microspray microneedle unit 2; Wherein, the liquid medicine is injected into the soft capsule 1 through the soft valve 7 on the soft capsule 1;

[0061] Step 2: The soft capsule 1 and the microspray and microneedle unit 2 are integrally fixed on the skin surface through the fixing unit 3; the fixing unit 3 is an adhesive medical adhesive tape or other wearable fixing materials.

[0062] Step 3: The controller 4 controls the dosage of the medicina...

Embodiment 3

[0066] A soft capsule microspray type microneedle transdermal drug delivery device, the difference from the drug delivery device described in Example 1 is that the setting positions of the microneedle grid 14 are different, such as Figure 4 As shown, in the drug delivery device in this embodiment, at least one or more fixed positions are set on the annular surface of the piezoelectric ceramic sheet, and a grid of microneedles is placed above each fixed position 14. The medicinal liquid enters the microspray microneedle unit from the soft capsule, and the medicinal liquid is ejected from the micropores of the diaphragm 11 to the skin. Since the position of the microneedle grid 14 is very close to the position of the skin where the medicinal liquid is sprayed, the medicinal liquid is sprayed out through the micropores of the membrane 11. The needle grid 14 punctures the stratum corneum of the skin, and when the medicinal liquid flows through the microneedle network 14 and conta...

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Abstract

The invention relates to the technical field of micro-needle transdermal delivery, in particular to a method and a device for soft capsule micro-jet type micro-needle transdermal delivery. The drug deliver device comprises a soft capsule which is used for storing medicine liquid, a micro-jet micro-needle unit which is capable of undergoing mechanical reciprocating vibration, a fixing unit and a controller, wherein one side of the soft capsule is bonded with and connected to a membrane of the micro-jet micro-needle unit and the other side of the soft capsule is bonded with and connected to the fixing unit; the micro-jet micro-needle unit is connected to the controller by virtue of a signal line; and the controller is used for controlling a delivery dosage of the medicine liquid and for controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each drug delivery. With the implementation of the method disclosed by the invention, by precisely controlling the drug delivery dosage and by controlling the micro-jet micro-needle unit to do mechanical reciprocating vibration before each drug delivery, various pores can generate in skin cuticula, which is conducive to the medicine liquid to permeate skin epidermis; and in addition, the device disclosed by the invention can achieve change the medicine liquid safely without pollution, and the device is simple and convenient to operate and use.

Description

technical field [0001] The invention relates to the technical field of microneedle transdermal drug delivery, in particular to a method and device for soft capsule micro-spray microneedle transdermal drug delivery. Background technique [0002] Microneedle, a micron-sized hollow or solid needle similar to an injection needle, is made of single crystal silicon material, metal or polymer, with a diameter of 30-80 μm and a length of 100-1000 μm. It can just pass through the stratum corneum without touching the pain-sensing nerve, and it can promote penetration without causing pain and skin damage. In recent years, microneedle drug delivery has attracted more and more attention. [0003] At present, there are still some disadvantages of microneedle devices: [0004] One of the disadvantages is that the active drug is smeared on the surface of the microneedle of the microneedle device, and the microneedle only wraps a small amount of drug. When puncturing the skin for administr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61M35/00
CPCA61M35/003A61M37/0015A61M2037/003A61M2037/0023A61M2037/0046
Inventor 唐晨
Owner 唐晨
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