Temperature-sensitive nanocapsules and preparation method thereof

A nanocapsule and temperature-sensitive technology, applied in the field of temperature-sensitive nanocapsules and its preparation, can solve the problems of high embedding rate, achieve high embedding rate, good biocompatibility, and reduce energy consumption

Active Publication Date: 2016-11-16
ANHUI MICRODELIVERY SMART MICROCAPSULE SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Temperature-sensitive nanocapsules and preparation method thereof
  • Temperature-sensitive nanocapsules and preparation method thereof
  • Temperature-sensitive nanocapsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～5

[0054] A preparation method of temperature-sensitive nanocapsules, the preparation steps are:

[0055] (1) Preparation of emulsifier aqueous solution: 1.5 parts of sodium dodecylsulfonate and 10 parts of deionized water were mixed to obtain an aqueous phase;

[0056] (2) Mix 10 parts of core material, 6 parts of N,N-diethylacrylamide, 6 parts of N,N-dimethylacrylamide, 1 part of ethylene glycol dimethacrylate, 0.1 part of azobisiso Butyronitrile and 1 part of hexadecane are mixed and stirred evenly to obtain an oil phase;

[0057] (3) adding the water phase to the oil phase, shearing at a shear rate of 6000rpm for 3min to form a microemulsion, and then ultrasonicating at a 50% amplitude for 10min to form a nanoemulsion;

[0058] (4) After the nanoemulsion is formed, the nitrogen protection is continued until the end of the reaction, and the temperature-sensitive nanocapsules are obtained by reacting at 40° C. for 3 hours.

[0059] When the core material is octocrylene, benzo...

Embodiment 6～10

[0062] A preparation method of temperature-sensitive nanocapsules, the preparation steps are:

[0063] (1) Prepare emulsifier aqueous solution: mix 2 parts of sodium dodecylsulfonate and 15 parts of deionized water to obtain an aqueous phase;

[0064] (2) 20 parts of core material, 8 parts of N,N-diethylacrylamide, 6 parts of N,N-dimethylacrylamide, 5 parts of 1,4-butylene glycol dimethacrylate, 0.2 parts Azobisisobutyronitrile and 1.1 parts of hexadecane are mixed and stirred evenly to obtain an oil phase;

[0065] (3) adding the water phase to the oil phase, shearing at a shear rate of 6500rpm for 4min to form a microemulsion, and then ultrasonically forming a nanoemulsion with a 50% amplitude for 12min;

[0066] (4) After the nanoemulsion is formed, the nitrogen gas protection is continued until the reaction is completed, and the temperature-sensitive nanocapsules are obtained by reacting at 42° C. for 4 hours.

[0067] When the core material is mint oil, rose essence, le...

Embodiment 11～15

[0070] A preparation method of temperature-sensitive nanocapsules, the preparation steps are:

[0071] (1) Preparation of emulsifier aqueous solution: 3 parts of sodium dodecylsulfonate and 20 parts of deionized water were mixed to obtain an aqueous phase;

[0072] (2) Mix 50 parts of water clear lotus essence, N,N-diethylacrylamide, N,N-dimethylacrylamide, 2 parts of 1,6-hexanediol dimethacrylate, 0.3 parts of azo Diisobutyronitrile and 1.2 parts of hexadecane are mixed and stirred evenly to obtain an oil phase;

[0073] (3) adding the water phase to the oil phase, shearing at a shear rate of 7000rpm for 5min to form a microemulsion, and then ultrasonicating at a 50% amplitude for 15min to form a nanoemulsion;

[0074] (4) After the nanoemulsion is formed, the nitrogen protection is continued until the reaction is completed, and the temperature-sensitive nanocapsules are obtained by reacting at 45° C. for 3 hours.

[0075] When the parts by weight of N,N-diethylacrylamide a...

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Abstract

The invention relates to temperature-sensitive nanocapsules and a preparation method thereof. Each prepared temperature-sensitive nanocapsule comprises a core material and a wall material. The preparation method comprises the steps: firstly, separately preparing a water phase and an oil phase, carrying out mixing, then, carrying out high-velocity shearing so as to form a microemulsion, and carrying out an ultrasonic or high-pressure homogenizing action so as to form a nano-emulsion; then, introducing nitrogen gas into the emulsion, and then, carrying out a reaction for 3 to 4 hours at the temperature of 40 DEG C to 80 DEG C in a manner of carrying out a whole process in a nitrogen gas environment, thereby preparing the temperature-sensitive nanocapsules, wherein the encapsulation rate is 90% to 94%, the particle size PDI of the nanocapsules is 0.09 to 0.17, and the particle size is smaller than 150nm. According to the temperature-sensitive nanocapsules and the preparation method thereof, monomers for forming wall materials of the nanocapsules are common biological materials, so that the nanocapsules have good biocompatibility; the formed wall materials of the nanocapsules have temperature sensitivity, the internal core materials can be subjected to controlled sustained release through temperature change, so that the temperature-sensitive nanocapsules have an extensive application prospect in the fields of daily chemical products, textiles and medicines.

Description

technical field [0001] The invention belongs to the technical field of nanocapsules and its preparation, and relates to temperature-sensitive nanocapsules and a preparation method thereof. Background technique [0002] Generally, the particle size of microcapsules is between 1 and 1000 μm. With the continuous progress of microcapsule technology and the continuous development of nanotechnology, the particle size of prepared microcapsules can be <1 μm, which is between 1 and 1000 nm. The range of microcapsules is called nanocapsules. Compared with traditional microcapsules, the advantages of nanocapsules are: (1) It is convenient for further surface modification of materials, improving the embedding rate, changing the distribution state and targeting; (2) The finished product of nano-microcapsules has good stability and is easy to process Application, storage and transportation; (3) The nanocapsules have good biocompatibility and low toxic and side effects; (4) can be made...

Claims

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Application Information

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IPC IPC(8): C08F220/54C08F222/14C08F2/44C08F2/26C08F2/30C08F4/04C08F4/34B01J13/02B01J13/16
CPCB01J13/025B01J13/16C08F2/26C08F2/30C08F2/44C08F4/04C08F4/34C08F220/54C08F222/102A61K8/11A61K8/8158A61K9/5138A61K9/5192A61K47/10A61K47/20A61K47/32A61K47/36A61K2800/10A61K2800/412A61Q19/00A61P3/02A61P35/00A23V2002/00A61K8/35A61K8/37A61K8/40A61K9/0004A61K9/5123A61Q13/00A61Q17/04A23L27/72A23L27/74B01J13/185C11B9/0003
Inventor 鲁希华赵迪王丽英
Owner ANHUI MICRODELIVERY SMART MICROCAPSULE SCI & TECH CO LTD
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