Medicine composition containing inorganic arsenic compounds and application thereof

A composition and inorganic arsenic technology, which can be used in pharmaceutical combinations, medical preparations containing active ingredients, inorganic active ingredients, etc., can solve the problem of insufficient activity, and achieve the advantages of reducing systemic toxicity, reducing therapeutic dose and application safety. Effect

Active Publication Date: 2016-12-14
NANTONG YUFUYUAN PHARMA CO LTD
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Problems solved by technology

More and more studies have found that scutellarin and its derivatives show good ...

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  • Medicine composition containing inorganic arsenic compounds and application thereof
  • Medicine composition containing inorganic arsenic compounds and application thereof
  • Medicine composition containing inorganic arsenic compounds and application thereof

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Embodiment

[0015] Breast cancer MDA-MB-231 cells in the logarithmic growth phase were seeded in 96-well plates, 3×10 per well 3 cells. Set CO 2 Samples were added after 24 hours of incubation at 37°C in an incubator. 10 μL of PBS solution was added to the control group; 5 μL of PBS solution and 5 μL of arsenic trioxide solution were added to the arsenic trioxide group; Wherein the final concentrations of scutellarin and scutellarin aglycone are respectively μmol L -1 , each group was set up with 6 multiple wells, and each experiment was repeated 3 times. Put in 37°C CO 2 in the incubator. After 48 hours, add 20 μL MTS solution, 37°C CO 2 Continue to incubate in the incubator for 2 hours, and measure the absorbance (A) at 490 nm with an automatic microplate reader. All of the above were completed under the funding of Yunnan Collaborative Innovation Center for Public Health and Disease Prevention and Control (2016YNPHXT15).

[0016] The specific result is

[0017] Table 1 Inhibito...

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Abstract

The invention discloses a medicine composition containing inorganic arsenic compounds and application thereof. The medicine composition comprises inorganic arsenic compounds, scutellarin or scutellarein, is used for preparing medicines for treating cancers, and has a better effect on cancer cell inhibition than that by singly using inorganic arsenic compounds and that by singly using scutellarin or scutellarein. According to the medicine composition, the treatment dosage of inorganic arsenic compounds can be reduced, the cancer inhibition effect can be enhanced, and the systematic toxin of inorganic arsenic compounds can be effectively reduced.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing an inorganic arsenic compound and its application, in particular to a pharmaceutical composition containing an inorganic arsenic compound and scutellarin or scutellarin aglycon, and its preparation for treating cancer drug application. Background technique [0002] In 1971, Han Taiyun of the First Affiliated Hospital of Harbin Medical College transformed a Chinese medicine containing arsenic into a medicine for treating leukemia. In 1973, Zhang Tingdong, Zhang Peng, etc. applied "Ailing No. 1" to treat chronic myeloid leukemia, which improved the hematological indicators and clinical symptoms of patients. It has been proved that the inorganic compound arsenic trioxide can treat relapsed or refractory acute promyelocytic leukemia (APL), and recent preliminary data show that arsenic trioxide also has an effect on other cancers, so the study of arsenic trioxide as an anticancer drug is one ...

Claims

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Application Information

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IPC IPC(8): A61K33/36A61P35/00A61K31/7048A61K31/352
CPCA61K31/352A61K31/7048A61K33/36A61K2300/00
Inventor 何越峰尚莉平妮娜王立萍姚树祥张若冰
Owner NANTONG YUFUYUAN PHARMA CO LTD
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