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Cross-linked chitosan microspheres, and preparation method and application thereof

A technology for cross-linking chitosan and chitosan, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of difficult removal of dye pollutants, narrow pH value range, weak bridging ability, etc. The effect of chemical stability, low equipment requirements, and easy operation

Active Publication Date: 2016-12-14
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

In this new process for making tiny particles called microcapsules that are stable when mixed together without losing their shape or causing damage during storage. These minute capsule sizes help create strong bonds between them while still allowing liquids like water molecules to pass through freely. They also provide excellent absorbency properties due to its large surface area per unit weight compared to traditional materials such as clay mineral powder.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the performance of various types of materials like plastic films, paper products, leather goods, clothing items made from them due to their unique characteristics including strong affinity towards specific substances called Different Chemistry Groups (chemical Formulae). These modifications involve modifying certain parts of these material's structures, but they often result in decreased functionality compared to unmodifiable ones. To address this issue, there was developed methods involving complex techniques like cross- linking between chondroitins and carboxymethanes, resulting in improved durability and reduced stickiness.

Method used

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  • Cross-linked chitosan microspheres, and preparation method and application thereof
  • Cross-linked chitosan microspheres, and preparation method and application thereof
  • Cross-linked chitosan microspheres, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Preparation of cross-linked chitosan microspheres

[0041] 1) Preparation of chitosan acetic acid solution: prepare 2% (vt) acetic acid solution with glacial acetic acid, get a certain amount of 2% acetic acid solution to be mixed with 3% (wt) chitosan acetic acid solution and magnetically stir at room temperature to dissolve completely After standing still, obtain uniform light brown viscous solution;

[0042]2) Preparation of oil phase and surfactant: use 3% chitosan acetic acid solution as water phase, liquid paraffin as oil phase, add oil phase: water phase = 3:1 volume ratio; use Span80 as surface active agent, the added volume ratio is 1 / 10 of the water phase;

[0043] 3) The preparation process of cross-linked chitosan microspheres: at room temperature, use a syringe to draw 10 mL of 3% chitosan acetic acid solution (chitosan mass is about 0.3 g) in step 1) and add it to the preparation in step 2). In a 250mL flat-bottomed flask with 30mL of liquid paraffin ...

Embodiment 2

[0048] 1. Preparation of cross-linked chitosan microspheres

[0049] 1) Preparation of chitosan acetic acid solution: prepare 2% (vt) acetic acid solution with glacial acetic acid, get a certain amount of 2% acetic acid solution to be mixed with 3% (wt) chitosan acetic acid solution and magnetically stir at room temperature to dissolve completely After standing still, obtain uniform light brown viscous solution;

[0050] 2) Preparation of oil phase and surfactant: use 3% chitosan acetic acid solution as water phase, liquid paraffin as oil phase, add oil phase: water phase = 3:1 volume ratio; use Span80 as surface active agent, the added volume ratio is 1 / 10 of the water phase;

[0051] 3) The preparation process of cross-linked chitosan microspheres: at room temperature, use a syringe to draw 10 mL of 3% chitosan acetic acid solution (chitosan mass is about 0.3 g) in step 1) and add it to the preparation in step 2). In a 250mL flat-bottomed flask with 30mL of liquid paraffin...

Embodiment 3

[0055] 1. Preparation of cross-linked chitosan microspheres

[0056] 1) Preparation of chitosan acetic acid solution: prepare 2% (vt) acetic acid solution with glacial acetic acid, get a certain amount of 2% acetic acid solution to be mixed with 3% (wt) chitosan acetic acid solution and magnetically stir at room temperature to dissolve completely After standing still, obtain uniform light brown viscous solution;

[0057] 2) Preparation of oil phase and surfactant: use 3% chitosan acetic acid solution as water phase, liquid paraffin as oil phase, add oil phase: water phase = 3:1 volume ratio; use Span80 as surface active agent, the added volume ratio is 1 / 10 of the water phase;

[0058] 3) The preparation process of cross-linked chitosan microspheres: draw 10 mL of 3% chitosan acetic acid solution (chitosan mass is about 0.3 g) in step 1) with a syringe at room temperature In a 250mL flat-bottomed flask with 30mL of liquid paraffin and 1mL of Span80, stir at a stirring rate o...

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Abstract

The invention discloses cross-linked chitosan microspheres, and a preparation method and application thereof, and belongs to the field of high polymer materials. The preparation method comprises the following steps: (1) dissolving chitosan powder in acetic acid solution to form an aqueous phase, adding an emulsifying agent into liquid paraffin, and mixing uniformly to form an oil phase; (2) injecting the aqueous phase into the oil phase, and stirring to form a water-in-oil type emulsion; (3) adding benzaldehyde into the water-in-oil type emulsion to generate Schiff alkali for protecting amino, adding a pore-foaming agent and stirring, adjusting the pH to be 9 to 10, and then adding epichlorohydrin and diethylenetriamine in sequence to perform cross-linking reaction; (4) after the cross-linking reaction is ended, separating to obtain a reaction product; (5) removing the oil phase and protecting groups from the reaction product, reducing to generate the amino, and washing and drying to obtain the cross-linked chitosan microspheres. The cross-linked chitosan microspheres prepared by the preparation method are small in particle size and high in dispersibility, and can be used as an adsorption agent for a dye, namely, Congo red; the chemical stability is improved.

Description

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Claims

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Application Information

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Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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