Application of fructus cnidii general flavone in preparation of medicines for treating perimenopausal syndrome

Abstract

The invention relates to application of fructus cnidii general flavone in preparation of medicines for treating perimenopausal syndrome, aiming at effectively solving the application problem of preparing perimenopausal syndrome medicines from fructus cnidii general flavone which serves as a unique active ingredient. The fructus cnidii general flavone is prepared by the following steps: grinding fructus cnidii into coarse powder; refluxing and extracting with petroleum ether, and degreasing; volatizing petroleum ether from fructus cnidii dregs, soaking in ethanol, refluxing and extracting, and filtering; reclaiming ethanol at reduced pressure until no alcohol smell exists; dispersing with distilled water to obtain a liquid medicine; passing the liquid medicine onto AB-8 type macroporous adsorption resin; eluting with distilled water, and removing water elution; eluting with ethanol having a mass concentration of 10 percent, and removing the elution; eluting with ethanol having a mass concentration of 80 percent, collecting the 80% ethanol elution, and reclaiming ethanol at reduced pressure until no ethanol smell exists; freeze-drying, and grinding to obtain the fructus cnidii general flavone. The fructus cnidii general flavone is rich in raw materials, simple in preparation method, easy to operate and high in preparation efficiency, can be used for effectively preparing medicines for treating the perimenopausal syndrome, and opens new application of fructus cnidii.

Description

technical field [0001] The invention relates to medicine, in particular to the application of total cnidium flavonoids in the preparation of medicines for treating perimenopausal syndrome. Background technique [0002] Cnidium monnieri (L.) Cuss., also known as wild carrot, is warm in nature, bitter in taste, warms kidney and strengthens yang, dries dampness, dispels wind, kills insects, and is used for impotence, uterine cold, cold-damp leukorrhagia, dampness and lumbago ; external treatment of genital eczema, women pruritus vulvae, trichomonal vaginitis. [0003] Perimenopausal syndrome refers to a period of time before and after menopause in women (from about 45 years old to within 12 months after menopause), including the endocrine, biological and clinical features related to menopause appearing near menopause until the last 1 year. One year after the first menstrual period, which is the sign of ovarian function decline, continues until one year after the last menstruat...

AI Technical Summary

Problems solved by technology

[0004] Although there are many kinds of drugs for treating perimenopause, there is no application of the total flavonoids of Cnidium extracted from Fructus Cnidii in the preparation of drugs for treating perimenopause.

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