Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of antiseptic composition for liquid pharmaceutical preparation

A liquid medicine and composition technology, which is applied in the directions of drug delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve problems such as easy side effects, and achieve the effects of less toxic side effects and high safety threshold.

Active Publication Date: 2019-11-08
ZHONGSHUAI PHARMA SCI & TECH CO LTD
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The above various preservatives have their own advantages and disadvantages, but the toxicity problem is a common problem, and they are prone to side effects in clinical practice

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of antiseptic composition for liquid pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preservative composition for liquid pharmaceutical preparations, in percentage by weight, is composed of the following raw materials: 5% of 1,2-propanediol, 30% of glycerol, and 55% of sorbitol.

[0031] The process of using it to prepare liquid pharmaceutical preparations: take the prescribed amount of sorbitol and add it to 30% of the prepared amount of water, heat at 60-65°C, stir to dissolve, add glycerin, propylene glycol, essence, pH adjuster and other auxiliary materials, stir and dissolve, and cool to a 20°C, add the main drug, dilute to volume with water, stir for 30 minutes, filter, and fill.

Embodiment 2

[0033] A preservative composition for liquid pharmaceutical preparations, in percentage by weight, is composed of the following raw materials: 5% of 1,2-propanediol, 20% of glycerol, and 45% of xylitol.

[0034] The process of using it to prepare liquid pharmaceutical preparations is the same as in Example 1.

Embodiment 3

[0036] A preservative composition for liquid pharmaceutical preparations, in percentage by weight, is composed of the following raw materials: 25% of 1,2-propanediol, 5% of glycerol, and 70% of mannitol.

[0037] The process of using it to prepare liquid pharmaceutical preparations is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to preservative composition which comprises the following raw materials in percentage by weight: 2-25% of 1, 2-propylene glycol, 5-30% of glycerol, 45-75% of sugar alcohol and 0-0.5% of a preservative. The preservative composition provided by the invention has an efficient broad-spectrum bacteriostasis effect, and plays a role of inhibiting pseudomonas aeruginosa, escherichia coli, staphylococcus aureus, candida albicans and aspergillus niger, and has higher safety threshold and fewer toxic and side effects.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a preservative composition suitable for liquid pharmaceutical preparations. Background technique [0002] Liquid pharmaceutical preparations include oral solutions, syrups, suspensions and emulsions, and the like. If the drug itself does not have sufficient antibacterial efficacy, appropriate bacteriostatic agents should be added according to the characteristics of the preparation (such as water-soluble preparations) to prevent the drug from deteriorating due to microbial contamination and reproduction during normal storage or use. Hazards, especially in multi-dose packaged preparations. In principle, a suitable bacteriostatic agent should meet the three aspects of effectiveness, safety and stability. All bacteriostatic agents have certain toxicity, so the dosage of bacteriostatic agent in the preparation should be the minimum effective amount. To be safe, the effecti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K47/26A61K47/14A61K47/12A61K9/08
CPCA61K9/08A61K47/10A61K47/12A61K47/14A61K47/26Y02A50/30
Inventor 程永科陈祖利
Owner ZHONGSHUAI PHARMA SCI & TECH CO LTD