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Medical antibacterial hydrogel dressing and preparation method thereof

A kind of antibacterial water and gel technology, applied in the field of medical materials, can solve the problems of limited popularization and application, easy infection, poor antibacterial performance, etc., and achieve the effect of long-lasting antibacterial effect, excellent healing ability, and smooth and delicate surface

Inactive Publication Date: 2016-12-21
林春梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nevertheless, there are still some shortcomings in hydrogel dressings: its own poor antibacterial property, easy to cause infection, in addition, it is not suitable for use on wound surfaces with a lot of penetrating fluid, which limits its better promotion and application to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A medical antibacterial hydrogel dressing, prepared from the following raw materials in parts by weight: 52 parts of thiolated chitosan, 11 parts of disodium 2-glycerophosphate, 3 parts of carbomer, and 7 parts of oxidized sodium alginate 4 parts, 4 parts of L-arginine ethyl ester hydrochloride, 2 parts of theophylline, 3 parts of glycine fumarate, 5 parts of L-carnitine, 2 parts of stachyose, 2 parts of hydroxyethyl methacrylate, 2 parts Tripropylene glycol diacrylate 1 part, ginkgo flavonoid 3 parts, polyhexamethylene biguanide 2 parts, povidone iodine 3 parts, andrographis paniculata alcohol extract 2 parts, triethanolamine 7 parts, deionized water 30 parts.

[0023] The Andrographis paniculata concentration of described Andrographis paniculata alcohol extract is 0.05mg / ml.

[0024] A preparation method of medical antibacterial hydrogel dressing, comprising the following preparation steps:

[0025] Step S1, adding thiolated chitosan and disodium 2-glycerophosphate t...

Embodiment 2

[0031] A medical antibacterial hydrogel dressing, prepared from the following raw materials in parts by weight: 68 parts of thiolated chitosan, 19 parts of disodium 2-glycerophosphate, 10 parts of carbomer, and 14 parts of oxidized sodium alginate 8 parts, 8 parts of L-arginine ethyl ester hydrochloride, 5 parts of theophylline, 8 parts of glycine fumarate, 11 parts of L-carnitine, 7 parts of stachyose, 6 parts of hydroxyethyl methacrylate, two Tripropylene glycol diacrylate 7 parts, ginkgo flavonoids 8 parts, polyhexamethylene biguanide 6 parts, povidone iodine 9 parts, andrographis paniculata alcohol extract 5 parts, triethanolamine 16 parts, deionized water 45 parts.

[0032] The Andrographis paniculata concentration of described Andrographis paniculata alcohol extract is 0.2mg / ml.

[0033] A preparation method of medical antibacterial hydrogel dressing, comprising the following preparation steps:

[0034] Step S1, adding thiolated chitosan and disodium 2-glycerophosphate ...

Embodiment 3

[0040] A medical antibacterial hydrogel dressing, prepared from the following raw materials, in parts by weight: 54 parts of thiolated chitosan, 14 parts of disodium 2-glycerophosphate, 4 parts of carbomer, 9 parts of oxidized sodium alginate 5 parts, 5 parts of L-arginine ethyl ester hydrochloride, 2.3 parts of theophylline, 3.5 parts of glycine fumarate, 5.5 parts of L-carnitine, 2.2 parts of stachyose, 2.4 parts of hydroxyethyl methacrylate, two 2 parts of tripropylene glycol diacrylate, 3.6 parts of ginkgo flavonoids, 2.1 parts of polyhexamethylene biguanide, 4 parts of povidone iodine, 3 parts of andrographis paniculata alcohol extract, 8 parts of triethanolamine, 32 parts of deionized water.

[0041] The Andrographis paniculata concentration of described Andrographis paniculata alcohol extract is 0.1mg / ml.

[0042] A preparation method of medical antibacterial hydrogel dressing, comprising the following preparation steps:

[0043] Step S1, adding thiolated chitosan and ...

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PUM

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Abstract

The invention discloses a medical antibacterial hydrogel dressing and a preparation method thereof. The hydrogel dressing is prepared from the following raw materials: thiolated chitosan, sodium glycerophosphate hydrate, carbomer, oxidized sodium alginate, L-arginine ethyl ester dihydrochloride, theophylline, glycine fumarate, L-carnitine powder, stachyose, hydroxyethyl methylacrylate, tri(propylene glycol) diacrylate, ginkgo flavonol, polyhexamethylene biguanidine, povidone iodine, alcoholic extract of herba andrographitis, triethanolamine and de-ionized water. The hydrogel dressing prepared by the invention can achieve inhibitory rates 91% and 94% or above on pseudomonas aeruginosa and staphylococcus aureus separately, and the hydrogel dressing has a broad-spectrum antibacterial property and a durable antibacterial effect; and in addition, the hemostasis time of the dressing is just 9-18s and healing time is shorter than 10d, and healed regenerated skin has a smooth and delicate surface; therefore, the hydrogel dressing is excellent in wound healing capacity and quite good in healing effect.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a medical antibacterial hydrogel dressing and a preparation method thereof. Background technique [0002] Traditional wound dressings such as gauze, cotton wool, etc. are easy to stick to the wound site, and it is easy to cause secondary damage to the wound granulation tissue when the dressing is replaced or removed. Wound dressings should provide and maintain a moist environment around the wound, be able to exchange gases, and at the same time act as a barrier to foreign pollutants and microorganisms. Ideal wound dressing materials should be non-toxic, non-adhesive, not cause allergic reactions in the body, and have antibacterial properties, swelling and absorption properties, etc. [0003] Hydrogel dressing refers to the preparation of natural or synthetic polymers alone or together to prepare a colloidal substance that can significantly swell in water bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L24/00A61L24/06A61L24/08
CPCA61L26/0023A61L24/0015A61L24/0031A61L24/06A61L24/08A61L26/0014A61L26/0066A61L26/008A61L2300/202A61L2300/206A61L2300/214A61L2300/216A61L2300/30A61L2300/404C08L5/08C08L5/04C08L33/02
Inventor 林春梅
Owner 林春梅
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