A traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine, can solve problems such as difficulties in enteral nutrition support, reflux, aspiration, increased ventilator-associated pneumonia, etc.

Inactive Publication Date: 2017-01-04
浙江中医药大学附属第一医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, under stress conditions, the gastrointestinal tract is often in an inhibited state, and its function is significantly weakened, resulting in difficulties in enteral nutrition support; and insufficient gastr

Method used

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  • A traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis
  • A traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis
  • A traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis

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Embodiment 1

[0087] 1 research object

[0088] The subjects of the study were severe sepsis patients who were continuously treated in the ICU of Zhejiang Provincial Hospital of Traditional Chinese Medicine, Zhejiang Provincial Tongde Hospital, Zhejiang Xinhua Hospital, Hangzhou Hospital of Traditional Chinese Medicine, and Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine from March 2013 to November 2014. Patients, a total of 551 cases, the selected patients met the inclusion criteria, and excluded the exclusion criteria. Finally, 296 patients were included in the analysis. The research protocol was approved by the hospital ethics committee, and all patients signed the informed consent form for clinical research by their legal representatives.

[0089] 1.1 Inclusion criteria

[0090] Refer to the diagnostic criteria for severe sepsis in the 2012 International Sepsis Guidelines: meet the diagnosis of sepsis with resulting organ dysfunction and / or tissue h...

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis which includes coptis, scutellaria, phellodendron, gardenia, peony bark, radix rehmanniae, radix paeoniae rubra, and fructus aurantii. The traditional Chinese medicine composition of this invention can significantly reduce the incidence of acute gastrointestinal injury in sepsis patients, significantly shorten mechanical ventilation and retention time of iCU and lower the 28 day mortality and gastrointestinal attributable mortality. These differences are statistically significant. This medicine can significantly reduce the severity of disease in patients with severe sepsis, relieve illness effectively, improve prognosis and have the advantages of safety without side effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular, the invention relates to a traditional Chinese medicine composition for preventing acute gastrointestinal injury caused by sepsis. Background technique [0002] Sepsis is an important clinical problem faced by critical care medicine. With the aging of the population, the increase in the incidence of tumors and the increase in invasive medical methods, the incidence of sepsis is constantly increasing, and millions of sepsis cases are newly diagnosed worldwide every year. disease patients, more than 1 / 4 of them died. Patients with sepsis have low immune function, which can easily lead to MODS. The most common occurrence is gastrointestinal dysfunction or failure, gastrointestinal mucosal injury, translocation of bacteria and toxins in the intestinal tract, and the formation of enterogenous infection, which in turn promotes the pathophysiology of MODS process, creating a v...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P1/00A61P31/00
CPCA61K36/539A61K36/65A61K36/71A61K36/718A61K36/744A61K36/752A61K36/756A61K36/804A61K2236/331A61K2236/333A61K2300/00
Inventor 江荣林寿迪文智屹慧朱美飞黄立权雷澍王灵聪
Owner 浙江中医药大学附属第一医院
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