A traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis

Abstract

The invention discloses a traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis which includes coptis, scutellaria, phellodendron, gardenia, peony bark, radix rehmanniae, radix paeoniae rubra, and fructus aurantii. The traditional Chinese medicine composition of this invention can significantly reduce the incidence of acute gastrointestinal injury in sepsis patients, significantly shorten mechanical ventilation and retention time of iCU and lower the 28 day mortality and gastrointestinal attributable mortality. These differences are statistically significant. This medicine can significantly reduce the severity of disease in patients with severe sepsis, relieve illness effectively, improve prognosis and have the advantages of safety without side effects.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular, the invention relates to a traditional Chinese medicine composition for preventing acute gastrointestinal injury caused by sepsis. Background technique [0002] Sepsis is an important clinical problem faced by critical care medicine. With the aging of the population, the increase in the incidence of tumors and the increase in invasive medical methods, the incidence of sepsis is constantly increasing, and millions of sepsis cases are newly diagnosed worldwide every year. disease patients, more than 1 / 4 of them died. Patients with sepsis have low immune function, which can easily lead to MODS. The most common occurrence is gastrointestinal dysfunction or failure, gastrointestinal mucosal injury, translocation of bacteria and toxins in the intestinal tract, and the formation of enterogenous infection, which in turn promotes the pathophysiology of MODS process, creating a v...

AI Technical Summary

Problems solved by technology

However, under stress conditions, the gastrointestinal tract is often in an inhibited state, and its function is significantly weakened, resulting in difficulties in enteral nutrition support; and insufficient gastrointestinal motility can easily cause reflux and aspiration, which increases the occurrence of ventilator-associated pneumonia (VAP). Shorten the duration of mechanical ventilation, ICU stay and total hospital stay

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