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Composition and application thereof for preventing or/and treating periodontal disease

A composition and gum technology, applied in the field of algae extract composition, can solve problems such as no good effect, achieve the effects of reducing inflammation, preventing and treating periodontal disease, and reducing inflammation

Active Publication Date: 2020-03-13
FAR EAST BIO TEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, except for surgical treatment of periodontal disease, drug treatment still has no good effect, so it is worthy of further research and development

Method used

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  • Composition and application thereof for preventing or/and treating periodontal disease
  • Composition and application thereof for preventing or/and treating periodontal disease
  • Composition and application thereof for preventing or/and treating periodontal disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment one: antibacterial test

[0037] 1. Culture of the main pathogenic bacteria of periodontal disease

[0038] Referring to the two journals of Jeong et al., 2000 and Zhou et al., 2006, two main periodontal pathogenic strains, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, were cultivated.

[0039] 2. Antibacterial test

[0040] According to the experimental design index of inhibiting 50% bacterial growth, observe that the phycocyanin-containing extract of different concentrations (25, 50, 100, 150, 300, 600 μg / ml) of the present invention is effective against Porphyromonas gingivalis (Porphyromonas gingivalis) (Such as Figure 1A ) and Actinobacillus actinomycetemcomitans (such as Figure 1B ) suppression phenomenon. in, Figure 1A and Figure 1B The abscissa of represents the addition of different concentrations (μg / ml) of the phycocyanin-containing extract, while the ordinate represents the absorbance value measured at a wavelength of ...

Embodiment 2

[0041] Example 2: Observation of Alveolar Bone Loss Phenomenon

[0042] 1. Experimental animals

[0043] The present invention adopts Sprague Dawley (SD) strain male rats to carry out the test, and the body weight of each rat is about 280-310 grams. The source of the rats is the National Animal Center (No. 128, Section 2, Yuanyuan Road, Nangang District, Taipei City), and they are kept in the Animal Center of National Defense Medical College (No. 161, Section 6, Minquan East Road, Neihu District, Taipei City). The breeding environment is 23- 25°C, the photoperiod is controlled at 12 hours day and night, the photoperiod time is 8:00-20:00, and sufficient feed and drinking water are supplied. In addition, the rearing room is regulated at the proper humidity and supplied with individually filtered air.

[0044] 2. Establishment of periodontal disease animal model

[0045] According to the journal published by Cai et al., 2008, the Ligature-induced periodontal disease model (Liga...

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PUM

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Abstract

The invention provides a composition containing phycocyanin. The composition can effectively inhibit the growth of oral pathogens including Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, and can reduce the inflammation reaction caused by the pathogens, so that the alveolus bone loss phenomenon of a patient with the periodontal diseases is retarded, and the effect of preventing and treating the periodontal diseases is achieved.

Description

technical field [0001] The invention provides a composition of algae extract, which contains phycocyanin, which can effectively inhibit the growth of oral pathogens including Porphyromonas gingivalis and Actinobacillus concomitante, and reduce the inflammatory reaction caused by the pathogens , to slow down the alveolar bone loss in patients with periodontal disease, and achieve the effect of prevention and treatment of periodontal disease. Background technique [0002] Periodontal disease is a chronic disease with a high prevalence rate all over the world. According to statistics from the Society of Periodontology, more than 90% of adults in Taiwan suffer from periodontal disease. In addition to the unattractive appearance of their teeth, these patients are more likely to cause other oral diseases and bad breath, which seriously affect interpersonal relationships and social life. Bacteria is the main cause of periodontal disease. Other factors include smoking, genetics, st...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/16A61K8/64A61P1/02A61P31/04A61Q11/00A61Q11/02
Inventor 周志中阙壮群
Owner FAR EAST BIO TEC
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