Composition, kit and method for detecting natural lung-cancer associated antibodies
A technology of composition and kit, applied in the field of immunology
Active Publication Date: 2017-01-04
上海英邈生物科技有限公司
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It is speculated that the risk of developing tumors in those who lack or are negative for natural antibodies may be significantly higher than that in the normal population
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[0056] 1. Sample collection
[0057] The plasma samples of 61 patients with early stage non-small cell lung cancer cell carcinoma (stage I and II squamous epithelial lung cancer and glandular epithelial lung cancer) before surgery and 108 healthy people were collected for the detection of plasma natural LCAA. All plasma samples were stored at minus 80 degrees (-80 degrees C) before the operation, and it was verified that the storage time was not more than two years, and there was no repeated freezing and thawing (the number of times was not more than 3).
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Abstract
The invention relates to a composition for detecting natural lung-cancer associated antibodies (LCAA), a kit prepared by the composition, a method for detecting the concentration of natural LCAA in plasma by using the composition or the kit, and an application of the composition or the kit in detecting the natural LCAA of the plasma. The composition, the kit and the method realize qualitative and quantitative detection for the natural LCAA in the plasma by utilizing six kinds of linear antigen polypeptides completely complementary with the target natural LCAA, and can be used for distinguishing the plasma (positive) with rich natural LCAA and the plasma (negative) without natural LCAA.
Description
Technical field [0001] The present invention belongs to the technical field of immunology and relates to 6 peptide antigens, which can be applied to prepare enzyme-linked immunosorbent assay (ELISA) antibody detection kits for detecting natural lung cancer-related antibodies in plasma. -associated antibody, LCAA) concentration. Background technique [0002] Malignant tumors are one of the most important killers that threaten the health of the entire human race. Due to the continuous existence of environmental pollution such as haze, haze, and haze, the incidence of major cancers in the Chinese population is increasing year by year. According to statistics, the current average annual incidence of cancer in my country is as high as 3 / 1000 or more. Early treatment methods for tumors, such as surgical resection or radiotherapy, have been developed and mature, which can significantly extend the survival time of patients. However, how to predict the risk of tumor incidence and diagn...
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IPC IPC(8): C07K14/715C07K14/47C07K14/525G01N33/68G01N33/574
CPCC07K14/47C07K14/4747C07K14/525C07K14/7155G01N33/57423G01N33/6854G01N2333/47G01N2333/525G01N2333/7155
Inventor 尉军孟庆勇
Owner 上海英邈生物科技有限公司