Application of 2-deoxy-D-glucose and pharmaceutically acceptable salt thereof in preparation of psoriasis treatment drug

A technology for glucose and psoriasis, applied in the field of drugs for the treatment of psoriasis, can solve the problems of no treatment method, unknown pathogenesis of psoriasis, complex etiology, etc., and achieves low research and development costs, clear toxicology and pharmacology, and popularization and application value. big effect

Inactive Publication Date: 2017-01-11
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Abstract
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Problems solved by technology

The pathogenesis of psoriasis is unknown, the etiolog...

Method used

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  • Application of 2-deoxy-D-glucose and pharmaceutically acceptable salt thereof in preparation of psoriasis treatment drug
  • Application of 2-deoxy-D-glucose and pharmaceutically acceptable salt thereof in preparation of psoriasis treatment drug
  • Application of 2-deoxy-D-glucose and pharmaceutically acceptable salt thereof in preparation of psoriasis treatment drug

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Embodiment

[0017] IMQ (imiquimod) is an agonist of Toll-like receptor 7 (TLR7), which can induce skin inflammation, cause keratinocyte hyperplasia and immune cell infiltration, resulting in psoriasis-like dermatitis. We randomly divided 20 8-week-old female BALB / c mice into 4 groups according to body weight, 5 mice in each group. They were divided into normal control group, 2-DG group, IMQ group, and 2-DG+IMQ group. The normal control group applied Vaseline on the back at the same time every day from the first day to the sixth day; On the first day, the second day, the fourth day, and the sixth day, respectively, subcutaneously inject 100ul 2-DG (the amount of 2-DG is administered according to the weight of the mouse, 500mg / Kg / mouse, dissolved in PBS); the first day of the IMQ group On the sixth day, at the same time every day, apply 5% IMQ ointment 60mg on the back; 2-DG+IMQ group received 2-DG and IMQ treatment. The skin lesions on the back of the mice were photographed with a digital...

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Abstract

The present invention discloses application of 2-deoxy-D-glucose and pharmaceutically acceptable salt thereof in the preparation of a psoriasis treatment drug. The 2-deoxy-D-glucose is an existing medicine, the toxicology and pharmacology of 2-deoxy-D-glucose are relatively clear, the research and development cost is low, the popularization and application value is large, and the 2-deoxy-D-glucose is suitable for the preparation of the externally applied agents and injection drugs for the treatment of psoriasis.

Description

technical field [0001] The invention relates to the application of 2-deoxy-D-glucose and pharmaceutically acceptable salts thereof in the preparation of medicines for treating psoriasis, and belongs to the field of medicines for treating psoriasis. Background technique [0002] Psoriasis is a common chronic inflammatory disease in dermatology. The main clinical manifestation is scaly erythema on the trunk and extremities, which can spread to the whole body and easily recurs. The pathogenesis of psoriasis is unknown, the etiology is complex, and there is currently no effective treatment. The histopathology is specific, manifested as hyperkeratosis of the epidermis with parakeratosis, regular hypertrophy of the spinous layer, and sparse inflammatory cell infiltration around the blood vessels in the superficial dermis. The most important pathological feature is acanthosis, which is caused by excessive proliferation of keratinocytes. Under the action of multiple genes and envi...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P17/06
CPCA61K31/7004
Inventor 陈翔陈明亮曾伟奇黄晓燕
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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