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Application of gemcitabine in preparation of medicine for treating psoriasis, medicine and preparation method thereof

A technology of gemcitabine and gemcitabine hydrochloride, applied in the pharmaceutical field, can solve problems such as unclear development mechanism of psoriasis

Active Publication Date: 2020-12-22
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism of occurrence and development of psoriasis is still unclear, especially the mechanism of persistent hyperactivity of T cells is still an unsolved mystery

Method used

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  • Application of gemcitabine in preparation of medicine for treating psoriasis, medicine and preparation method thereof
  • Application of gemcitabine in preparation of medicine for treating psoriasis, medicine and preparation method thereof
  • Application of gemcitabine in preparation of medicine for treating psoriasis, medicine and preparation method thereof

Examples

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preparation example Construction

[0051]The present invention also provides a method for preparing the injection medicine for treating psoriasis in one embodiment. The preparation method includes the following steps: adding gemcitabine or gemcitabine hydrochloride to a solvent for dissolution to obtain an injection medicine. The preparation method has simple process and low cost.

[0052]The invention also provides an embodiment of an external ointment for treating psoriasis. The external ointment is mainly prepared from a pharmaceutically acceptable base and gemcitabine or gemcitabine hydrochloride as active ingredients.

[0053]The above-mentioned topical ointment not only improves the efficacy of the injection, but in mice with psoriasis-like inflammation, it reduces the symptoms including skin lesions, thickening of the stratum corneum, the number of MDSCs, etc., and is more convenient to use; it also significantly reduces the toxicity. side effect.

[0054]Further, the base is a combination of lanolin, white petrolatum ...

Embodiment 1

[0063]The injection drug for the treatment of psoriasis of Example 1 is prepared by mixing gemcitabine hydrochloride and a phosphate buffered saline solution with a pH of 7.2 to 7.4 to prepare an injection drug. The mass ratio of gemcitabine hydrochloride to injection drug is 80mg:1Kg.

[0064]Examples 2 to 3 are basically the same as Example 1, except that the mass ratio of gemcitabine hydrochloride to injection drug is 60mg:1Kg and 100mg:1Kg, respectively.

Embodiment 4

[0065]Example 4 is basically the same as Example 1, except that the phosphate buffered saline solution with a pH of 7.2 to 7.4 is replaced with physiological saline.

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Abstract

The invention relates to an application of gemcitabine in preparing a drug for treating psoriasis, the drug and a preparation method thereof. The inventor finds that gemcitabine which is originally used for treating advanced non-small cell lung cancer has the function of treating psoriasis through researches. The application combines gemcitabine to provide a novel application, thereby providing anovel drug for treating psoriasis. Researches find that gemcitabine is obvious in efficacy and wide in application prospect and has relatively great popularizing and applying value. As gemcitabine isan existing drug which is relatively clear in toxicology and pharmacology, the research and development costs are also lowered.

Description

Technical field[0001]The invention relates to the technical field of pharmacy, in particular to an application of gemcitabine in the preparation of a medicine for treating psoriasis, the medicine and a preparation method thereof.Background technique[0002]Psoriasis is a common chronic inflammatory disease in dermatology. The clinical manifestation is mainly scaly erythema on the trunk and limbs, which can spread to the whole body and is easy to recur. Psoriasis vulgaris is the most common type of psoriasis. At present, there are many drugs for psoriasis vulgaris, most of which are hormones and immunosuppressive drugs, such as glucocorticoid drugs, tretinoin drugs and vitamin D3 analogs. The pathogenesis of psoriasis is complicated. Although there are many clinical treatment methods, the curative effect is not ideal, which seriously affects the quality of life of patients.[0003]With recent studies on psoriasis, it has been discovered that psoriasis is a common immune-mediated inflamma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7068A61K9/06A61P17/06
CPCA61K9/0014A61K9/0019A61K9/06A61K31/7068A61K47/06A61K47/44
Inventor 彭聪陈翔谭丽蓉朱武周星辰
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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