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Application of gemcitabine in preparing drug for treating psoriasis, drug and preparation method thereof

A technology of gemcitabine and gemcitabine hydrochloride, applied in the field of pharmaceuticals, can solve the problems of unclear development mechanism of psoriasis

Active Publication Date: 2018-12-11
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism of occurrence and development of psoriasis is still unclear, especially the mechanism of persistent hyperactivity of T cells is still an unsolved mystery

Method used

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  • Application of gemcitabine in preparing drug for treating psoriasis, drug and preparation method thereof
  • Application of gemcitabine in preparing drug for treating psoriasis, drug and preparation method thereof
  • Application of gemcitabine in preparing drug for treating psoriasis, drug and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0051] The present invention also provides a preparation method of the above-mentioned injection medicine for treating psoriasis according to one embodiment. The preparation method comprises the following steps: adding gemcitabine or gemcitabine hydrochloride into a solvent for dissolution to obtain injection medicine. The preparation method has simple process and low cost.

[0052] The present invention also provides an external ointment for treating psoriasis according to one embodiment. The external ointment is mainly prepared from a pharmaceutically acceptable base and gemcitabine or gemcitabine hydrochloride as an active ingredient.

[0053] Compared with the injection, the above-mentioned external ointment not only improves the drug efficacy, but also relieves symptoms in mice with psoriasis-like inflammation, including skin lesions, thickened stratum corneum, and the number of MDSCs, and is more convenient to use; it also significantly reduces toxicity. side effect. ...

Embodiment 1

[0063] The injection medicine for treating psoriasis of Example 1 is prepared by mixing gemcitabine hydrochloride and phosphate buffered saline solution with a pH of 7.2-7.4. Wherein the mass ratio of gemcitabine hydrochloride to injection medicine is 80mg:1Kg.

[0064] Embodiments 2-3 are basically the same as Embodiment 1, except that the mass ratios of gemcitabine hydrochloride to injection drugs are 60mg:1Kg and 100mg:1Kg, respectively.

Embodiment 4

[0065] Example 4 is basically the same as Example 1, except that the phosphate buffered saline solution with a pH of 7.2-7.4 is replaced by physiological saline.

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Abstract

The invention relates to an application of gemcitabine in preparing a drug for treating psoriasis, the drug and a preparation method thereof. The inventor finds that gemcitabine which is originally used for treating advanced non-small cell lung cancer has the function of treating psoriasis through researches. The application combines gemcitabine to provide a novel application, thereby providing anovel drug for treating psoriasis. Researches find that gemcitabine is obvious in efficacy and wide in application prospect and has relatively great popularizing and applying value. As gemcitabine isan existing drug which is relatively clear in toxicology and pharmacology, the research and development costs are also lowered.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to an application of gemcitabine in preparing a medicine for treating psoriasis, a medicine and a preparation method thereof. Background technique [0002] Psoriasis is a common chronic inflammatory disease in dermatology. The main clinical manifestation is scaly erythema on the trunk and extremities, which can spread to the whole body and easily recurs. Psoriasis vulgaris is the most common type of psoriasis. At present, there are many drugs for the treatment of psoriasis vulgaris, most of which are hormones and immunosuppressant drugs, such as glucocorticoids, retinoic acid drugs and vitamin D3 analogues. The pathogenesis of psoriasis is complicated. Although there are many clinical treatment methods, the curative effect is not satisfactory, which seriously affects the quality of life of patients. [0003] With recent research on psoriasis, psoriasis is a common immune-mediated...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7068A61K9/06A61P17/06
CPCA61K9/0014A61K9/0019A61K9/06A61K31/7068A61K47/06A61K47/44
Inventor 彭聪陈翔谭丽蓉朱武周星辰
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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