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Application of isoproterenol and its pharmaceutically acceptable salts in the preparation of antitumor drugs

A technology of isoproterenol and anti-tumor drug, applied in the field of anti-tumor drugs, can solve the problem that there is no active ingredient of isoproterenol, and achieve the effects of clear toxicology and pharmacology, high promotion and application value, and low research and development cost.

Active Publication Date: 2018-07-13
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no relevant report on isoproterenol as an active ingredient of antitumor drugs

Method used

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  • Application of isoproterenol and its pharmaceutically acceptable salts in the preparation of antitumor drugs
  • Application of isoproterenol and its pharmaceutically acceptable salts in the preparation of antitumor drugs
  • Application of isoproterenol and its pharmaceutically acceptable salts in the preparation of antitumor drugs

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Experimental program
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Embodiment Construction

[0021] The present invention will be further described below in conjunction with embodiment.

[0022] Experimental Materials

[0023] Cell lines: Human malignant melanoma A375, SK-mel-28, SK-mel-5, B16F10 cell lines, lung cancer A549 cell line, colon cancer HCT116 cell line, and black drug-resistant strain RA are all preserved in our laboratory . Isoproterenol (No. I129810, purity ≥ 99%) was purchased from Shanghai Aladdin Biotechnology Co., Ltd. The mother solution was dissolved in PBS to the corresponding concentration and stored at -20°C. High-glucose DMEM medium, fetal bovine serum, and trypsin were all purchased from Hyclone Company of the United States, and Matrigel was purchased from BD Company of the United States. CO 2 The incubator was purchased from Thermo Company of the United States, the inverted microscope was purchased from Olympus Company of Japan, and the desktop centrifuge was purchased from BECKMAN Company of the United States.

[0024] experimental met...

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Abstract

The invention discloses isoproterenol and application of pharmaceutically-acceptably salt of the isoproterenol to preparation of antineoplastic drugs. The structural formula of the isoproterenol is shown in the description. The isoproterenol is an existing drug, and the toxicology and pharmacology of the isoproterenol are relatively distinct. The isoproterenol is low in research and development cost and large in popularization and application value. The isoproterenol can restrain activity of tumor cells of melanoma, lung cancer and colon cancer and is especially suitable for treating malignant melanoma of the human.

Description

technical field [0001] The invention relates to the application of isoproterenol and a pharmaceutically acceptable salt thereof in the preparation of antitumor drugs, and belongs to the technical field of antitumor drugs. Background technique [0002] Isoproterenol, also known as Chuanxiding, isoproterenol sulfate, isoproterenol hydrochloride, isoproterenol, isoproterenol, Zhichuanling, is a non-selective β-adrenergic receptor agonist. Its hydrochloride is commonly used, which is white or off-white crystalline powder, odorless, slightly bitter taste, gradually changes color when exposed to light and air, and is more likely to change color in alkaline solution. Soluble in water, slightly soluble in ethanol, insoluble in chloroform or ether. At present, it is mainly used for bronchial asthma and cardiac atrioventricular block. It is widely used in clinical practice, and its effective blood concentration is 0.5-2.5ng / mL (2-10nM). However, so far, there is no relevant report ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/137A61P35/00
CPCA61K31/137
Inventor 彭聪陈翔周优优黄遵楠
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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