Synthesis method of beta-alanine methyl ester salt product

A kind of technology of alanine methyl ester and synthesis method, which is applied in the field of synthesis of β-alanine methyl ester salt products, can solve the problems of a large number of organic solvents, toxicity, harsh production environment requirements, etc., and achieve low environmental pollution and easy control , the effect of simple operation

Inactive Publication Date: 2017-01-11
JING JING PHARMA
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the synthesis method of β-alanine methyl ester salt has complex conditions, requires a large amount of organic solvents, and has extremely harsh requirements on the production environment.
At the same time, the industrially synthes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 300g of β-alanine and add it into 1900g of methanol and stir, and slowly add 400g of concentrated sulfuric acid at 19-21°C. After the addition of concentrated sulfuric acid, the temperature was raised to 65-68°C, refluxed for 8 hours, and the temperature was lowered to 24°C. The methanol solution of β-alanine methyl ester sulfate was concentrated under vacuum at 45°C until no methanol was evaporated. The concentrated solution was lowered to 22°C, 2500ml of purified water was added, and the pH of the β-alanine methyl sulfate aqueous solution was adjusted to 2.5 with ammonia water. Store the prepared β-alanine methyl ester sulfate aqueous solution at 7°C.

[0022] Obtain 2850ml of β-alanine methyl ester sulfate aqueous solution, the content of methyl ester is 115.7g / L, and the yield of methyl ester is 95%.

Embodiment 2

[0024] Take 300g of β-alanine and add it into 1900g of methanol and stir, and slowly add 400g of concentrated sulfuric acid at 19-21°C. After the addition of concentrated sulfuric acid, the temperature was raised to 65-68°C, refluxed for 8 hours, and the temperature was lowered to 23°C. The methanol solution of β-alanine methyl ester sulfate was concentrated under vacuum at 45°C until no methanol was evaporated. The concentrated solution was lowered to 23°C, 2500ml of purified water was added, and the pH of the β-alanine methyl sulfate aqueous solution was adjusted to 2.5 with ammonia water. Store the prepared β-alanine methyl ester sulfate aqueous solution at 7°C.

[0025] Obtain 2850ml of β-alanine methyl ester sulfate aqueous solution, the content of methyl ester is 112g / L, and the yield of methyl ester is 92%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a synthesis method of a beta-alanine methyl ester salt product, and relates to the technical field of beta-alanine methyl ester salt production. The method includes the following steps of firstly, adding beta-alanine to methyl alcohol to be stirred, and adding concentrated sulfuric acid; secondly, conducting backflow after feeding of concentrated sulfuric acid ends; thirdly, concentrating a methyl alcohol solution of beta-alanine methyl ester salt; fourthly, adding the concentrated solution to purified water to be evenly stirred, adjusting the PH of a water solution of beta-alanine methyl ester salt through ammonium hydroxide, and storing the prepared water solution of beta-alanine methyl ester salt at low temperature. The method has the advantages of being high in yield, easy to operate and easy to control; the method is free of toxic and corrosive gases in the synthesis process, small in environment pollution and beneficial to large-scale production.

Description

technical field [0001] The invention relates to the technical field of production methods of β-alanine methyl ester salt products. Background technique [0002] Alanine methyl ester salt is mainly used as pharmaceutical intermediates and scientific research reagents, and is widely used in scientific research such as molecular biology and pharmacology. [0003] β-alanine methyl ester salt is very soluble in water, ethanol, acetone and other organic solvents. At present, the synthesis method of β-alanine methyl ester salt has complex conditions, requires a large amount of organic solvents, and has extremely strict requirements on the production environment. At the same time, the industrially synthesized β-alanine methyl ester salt is mainly β-alanine methyl ester hydrochloride (chemical formula is C 4 h 9 NO 2 ·HCl), its molecules contain hydrogen chloride, which has certain toxicity and is not conducive to large-scale safe production. Contents of the invention [0004]...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C227/18C07C229/08
CPCC07C227/18C07C229/08
Inventor 李斌水米造吉刘玉兵马静杨涛
Owner JING JING PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap