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Nasal wash and its preparation method and application

A technology for lotion and nasal cavity, applied in the field of medicine, can solve the problems of uncontrollable bacterial and fungal infections, aggravated infections, limited therapeutic effect of bacterial and fungal infections, etc. Effects of Nasal Bacterial and Fungal Infections

Inactive Publication Date: 2019-12-06
朱高
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But hypertonic saline can only improve symptoms, not control bacterial and fungal infections
Hormone nasal agents, such as mometasone furoate, budesonide, fluticasone propionate nasal spray, etc. These drugs have a better effect on allergic rhinitis, but they are contraindicated for bacterial and fungal infections. Long-term use of steroid nasal drops agents may aggravate the infection
Traditional Chinese medicine nasal drops, such as compound menthol, cangyi, thirteen flavor magnolia nasal drops, etc., can improve clinical symptoms, but the therapeutic effect on bacterial and fungal infections is limited

Method used

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  • Nasal wash and its preparation method and application
  • Nasal wash and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Allicin used in the nasal cavity washing liquid of the present invention can preferably adopt the following method to extract (embodiment 1), and the steps are as follows:

[0038] Take 1000 grams of garlic seeds, peel and wash them first, crush them with a grinder at a speed of 1800 rpm for 30 seconds, and then enzymatically hydrolyze them for 0.5 hours at a pressure of 101.325kPa and 40-41°C to obtain garlic paste, add 95% (volume fraction) ethanol of 2 times the volume of garlic paste, after maintaining 1 hour at room temperature, the resulting garlic-ethanol mixture was centrifuged at a speed of 1800 rpm for 3 minutes, filtered with double-layer filter paper, and the filtrate was distilled under reduced pressure The ethanol is recovered until it is detected that the recovered ethanol does not contain allicin, and the allicin extract is obtained, and the allicin content is determined by the sulfur determination method.

[0039] During the above extraction process, th...

Embodiment approach 2

[0044] Take 1000 grams of garlic seeds, peel and wash them first, crush them with a pulverizer at a speed of 2000 rpm for 20 seconds, and then enzymatically hydrolyze them for 1 hour at a pressure of 80kPa and at a temperature of 40-41°C to obtain garlic puree. Garlic 6 times the volume of 95% ethanol, after maintaining at room temperature for 2 hours, the resulting garlic-ethanol mixture was centrifuged at a speed of 2000 rpm for 2 minutes, filtered through double-layer filter paper, and the filtrate recovered ethanol by vacuum distillation until detection When the recovered ethanol does not contain allicin, an allicin extract is obtained.

Embodiment 2

[0046] A nasal cavity washing liquid of the present invention is mainly composed of allicin and distilled water, and the mass volume ratio of allicin to distilled water (final solvent amount) is 0.02% g / ml.

[0047] In this embodiment, the nasal wash also includes sodium bisulfite and polysorbate-80, which are used for antisepsis, dispersion and dissolution aid, so as to keep the nasal wash stable.

[0048] The nasal wash of this embodiment can be used for various acute and chronic sinusitis.

[0049] A preparation method of the above-mentioned nasal cavity washing liquid of the present embodiment, comprises the following steps:

[0050] Add 20 g of the allicin extract into 500 ml of distilled water (initial solvent). The allicin extract is preferably the allicin extract prepared in Embodiment 1 of Example 1. After heating to 40° C. (slight heat), add 10 wt % sulfurous acid Sodium hydrogen solution 5ml and 10wt% polysorbate-80 solution 230ml, both solvents are distilled water...

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Abstract

The invention discloses a nasal lotion as well as a preparation method and an application thereof. The nasal lotion mainly consists of allicin and a solvent. The preparation method comprises the following steps: adding the allicin to the initial solvent; conducting heating, and adding a sodium hydrogen sulfite solution and a polysorbate-80 solution; regulating a pH value to 6.0-6.5; conducting filtering; preserving an obtained filtrate for the first time at 60-80 DEG C and preserving the filtrate for the second time at 0-4 DEG C; conducting filtering once again; regulating the allicin to a preset concentration by virtue of the solvent; and regulating the pH value to 6.0-6.5, so that the nasal lotion is obtained. The nasal lotion provided by the invention can effectively inhibit paranasal sinus bacterial and / or fungal infection and is free from obvious side effects; the preparation method can be simply and easily implemented and the preparation method is low in cost; and with the application of the nasal lotion, a product for treating sinusitis can be prepared.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the preparation of medicines for treating sinusitis, in particular to a nasal cavity wash and its preparation method and application. Background technique [0002] Sinusitis is a common disease. Common bacteria include Streptococcus pneumoniae, Hemolytic Streptococcus, Staphylococcus, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus, anaerobic bacteria, etc. Fungal infection is also a pathogenic factor. Sinusitis manifests as chills, fever, general discomfort, lack of energy, and loss of appetite. Local manifestations include nasal obstruction, purulent nasal discharge, headache and decreased sense of smell. Treatment includes antibiotics to control infection, drug nasal drops to shrink the nasal cavity, maxillary sinus puncture, hormone therapy, traditional Chinese medicine, physical therapy, hypertonic saline irrigation, surgery, etc. [0003] Nasal irrigation is an important...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/255A61K47/26A61K47/02A61P11/02A61P31/04A61P31/10A61P31/02
CPCA61K9/0043A61K9/08A61K31/255A61K47/02A61K47/26
Inventor 朱高
Owner 朱高
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