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72results about How to "Reduced antibacterial effect" patented technology

Novel water soluble natural polysaccharide antibacterial material and preparation method thereof

The invention discloses a novel water soluble natural polysaccharide antibacterial material. The molecules of the novel water soluble natural polysaccharide antibacterial material not only have guanidyl but also have amino acid groups, so that the biosafety of the novel water soluble natural polysaccharide antibacterial material is considered while the antibacterial property of chitosan is improved, and the novel water soluble natural polysaccharide antibacterial material is small in cytotoxicity and is a green antibacterial product. The invention also discloses a method of preparing the material. The method comprises the following steps: 1) dissolving chitosan in a diluted acid solution to obtain a diluted acid aqueous solution of chitosan; 2) adding cyanamide or dicyanamide into the diluted acid solution of chitosan for reaction; 3) adding an amino acid activated solution into a reaction system in the step 2) for amidation; 4) adding hydroxylamine hydrochloride for terminating reaction; and 5) dialyzing a reaction liquid which is filtered with deionized water, and performing microwave vacuum drying treatment to obtain the novel water soluble natural polysaccharide antibacterial material. The novel water soluble natural polysaccharide antibacterial material can be prepared in a reaction kettle by a primary reaction, and the used primary raw materials are rich in source and low in price and are suitable for industrial production.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI

Method for preparing compound biological activity sterilizing fluid

The invention discloses a method for preparing compound biological activity sterilizing fluid, which comprises the steps: a proper amount of surface active agent is added to low molecular chitosan quaternary ammonium salt or low molecular chitosan solution under a stirring condition to be used as first fluid, povidone iodine is swelled to be used as second fluid, and the first fluid and the second fluid are evenly mixed according to a proper proportion and are regulated to a prescriptive range by a chemical reagent to obtain the compound biological activity sterilizing fluid. The prepared compound biological activity sterilizing fluid uses low molecular chitosan and povidone as double carriers, the chitosan not only can strengthen the bacterium inhibiting and sterilizing effects of the povidone iodine, but also has a certain adsorbing function for iodine released by the povidone iodine, causes the release of the iodine to be doubly controlled to reduce the volatilization of the iodine and increase the release uniformity of the iodine, the chitosan has degradability, the skin mucosa protecting function and the bacterium inhibiting function, therefore, the compound biological activity sterilizing fluid is stable and environmental-friendly and has high efficiency, low toxicity, low irritation and the skin protecting function.
Owner:山东贝诺医药生物科技有限公司

Glycerol monolaurate microcapsule as well as preparation method and application of glycerol monolaurate microcapsule

The invention discloses a glycerol monolaurate microcapsule as well as a preparation method and an application of the glycerol monolaurate microcapsule. The preparation method comprises the following steps that: the glycerol monolaurate and emulsifying agents are dissolved into water being 60 to 70 DEG C to obtain solution A; wall materials are dissolved into the water being 60 to 70 DEG C to obtain solution B; the solution A and the solution B are mixed when the solution A and the solution B are still hot, stirring is carried out, and emulsion is obtained; and the emulsion is subjected to homogenizing and spray drying to obtain the glycerol monolaurate microcapsule, wherein the emulsifying agents are at least one kind of materials from sucrose ester, granulesten and fatty acid monoglyceride; and the wall materials are a mixture of maltodextrin and high-molecular compounds. The method provided by the invention is simple and practical, the controllability is strong, and the microencapsulation efficiency on core materials is higher; and the prepared glycerol monolaurate microcapsule has good flowability, dissolution dispersibility and mouth feeling, in addition, the anti-bacterium effect is not obviously reduced, and the glycerol monolaurate microcapsule can be applied to infant formula powder and realizes the effects of enhancing the immunity and resisting the infection.
Owner:ZHEJIANG UNIV +1

Method for preparing pharmaceutical composition for treating diseases of urinary system and method for detecting components thereof

The invention relates to a method for preparing a pharmaceutical composition for treating diseases of the urinary system and a method for detecting components thereof. The pharmaceutical composition comprises the components of desmodium styracifolium, corn silk, pyrrosia lingua, herba abri, tuckahoe, herba plantaginis, lygodium japonicum and rhizoma imperatae. The method for preparing the pharmaceutical composition comprises the following steps: step 1: dividing the tuckahoe into two parts; step 2: pulverizing the part of the tuckahoe accounting for 80-90% of total weight into fine powder; step 3: decocting the rest tuckahoe and the other seven crude drugs with water; and step 4: adding the fine tuckahoe powder, evenly mixing, drying, pulverizing into fine powder, screening, adding proper amounts of auxiliary materials, evenly mixing, pelletizing, drying, and sorting up the granules. The detecting method comprises the following steps: taking the pharmaceutical composition as the sample solution, and taking a pyrrosia lingua control medicine as the control medicine solution. The preparation technique and the detecting technique of the invention have the advantages of low cost and simple processing, reduce the heating time of the drugs, and are suitable for wide application in clinical treatment.
Owner:JIANGXI HONGXING PHARMA

Functional stitch-bonded non-woven fabric and preparation method thereof

ActiveCN105970488AReduced antibacterial effectHigh content of hydrophilic fiberNon-woven fabricsPolyesterPolymer science
The invention discloses functional stitch-bonded non-woven fabric and a preparation method thereof. The functional stitch-bonded non-woven fabric comprises a hydrophobic layer I, a hydrophilic layer and a hydrophobic layer II which are stacked sequentially together, wherein all of the hydrophobic layer I, the hydrophilic layer and the hydrophobic layer II are made of hydrophobic fibers, hydrophilic fibers and hot-melt bonding fibers. The stitch-bonded non-woven fabric has function gradients comprising intensity gradients, moisture absorption gradients and antibacterial gradients and has the effects of breathability, high strength, wear resistance, tear resistance, moisture absorption, fast drying and bacterial resistance. The provided stitch-bonded non-woven fabric has a one-way moisture conducting property and can be used for manufacturing an insole of a shoe, and the comfort degree of feet is improved. Ramie-polyester blended materials are selected, the non-woven fabric has light and soft texture, high strength and good one-way moisture conducting effect and can effectively absorb moisture, moisture loss is avoided, a hydrophobic surface contacted with skin of feet is kept dry, and more comfortable feelings are brought to users using the one-way moisture-conducting product.
Owner:LI NING CHINA SPORTS GOODS +2

High-efficiency antibacterial ultra-filtration membrane and preparation process thereof

InactiveCN105642134AImprove antibacterial propertiesThe antibacterial ability did not decrease significantlyMembranesSemi-permeable membranesFiltration membranePolyhexamethylene guanidine
The invention discloses a high-efficiency antibacterial ultra-filtration membrane and a preparation process thereof. By adopting a solution phase inversion method, the preparation process comprises the following steps: adding a nano antibacterial material into a membrane casting solution, adding a grafting initiator, and grafting the organic antibacterial material onto a macromolecular material, thereby preparing the antibacterial ultra-filtration membrane. By adopting the organic / inorganic antibacterial material which does not influence the performance of the ultra-filtration membrane, polyhexamethylene guanidine is macromolecular polymer powder with positive charges, can have reaction with a microbial cell membrane and is slightly soluble in the water, and the polyhexamethylene guanidine is grafted to a high polymer by utilizing a grafting agent, so that the stability is further guaranteed, and the loss and dropping along the time can be avoided. An inorganic antibacterial agent can effectively inhibit the breeding and growth of bacteria on the macromolecular membrane material; and when the inorganic antibacterial agent is combined with an organic antibacterial agent to use, the antibacterial effect is more remarkable.
Owner:SHANGHAI EMATE INDAL

Carrier-immobilized bacterial inhibition type water purifier for marine aquaculture and preparation method thereof

ActiveCN104789548AOvercome rapid deteriorationOvercome the problem of frequent epidemicsMicroorganism based processesOn/in organic carrierMarine aquacultureWater quality
The invention discloses a carrier-immobilized bacterial inhibition type water purifier for marine aquaculture and a preparation method thereof. The carrier-immobilized bacterial inhibition type water purifier is prepared by adsorbing and curing a mixed fermentation solution containing bacillus subtilis YB-01 CGMCC-No.9756 and brevibacillus laterosporus YB-02 CGMCC-No.9757. The strain of the water purifier is bacillus separated from a seawater source and has an excellent water purification effect and bacterial inhibition effect; kieselguhr and corncob powder are used as viable bacteria carriers, so that the water purifier is high in environmental tolerance, highly controllable in floatability, suspension property and sinking and floating properties and remarkable in three-dimensional purification effect on aquaculture water. By virtue of the water purifier, the harmful materials such as ammonia nitrogen, nitrite and hydrogen sulfide in the marine aquaculture water can be quickly degraded; the heavy metal ions in bottom mud can be efficiently adsorbed; deterioration, acidification and smelly bottom mud of the water can be avoided; the growth of main pathogenic bacteria in the marine aquaculture can be inhibited; diseases can be effectively prevented.
Owner:DALIAN UNIV OF TECH

Preparation method of degradable photocatalyst antibacterial mask

The invention discloses a preparation method of a degradable photocatalyst antibacterial mask, and relates to the technical field of masks, and the preparation method comprises the following steps: (1) preparing a degradable nose bridge strip; (2) preparing a mask body; and (3) mounting the degradable nose bridge strip on the mask body. The method has the advantages that the degradable nose bridgestrip and melt-blown cloth are both made of polylactic acid as raw materials and have degradability, all the raw materials of the degradable nose bridge strip have a synergistic effect, so that the prepared degradable nose bridge strip is relatively good in rebound rate and strength, and when the ratio of polylactic acid to silicone oil to titanium dioxide is changed, the prepared nose bridge strip cannot be formed, and the rebound rate and the strength cannot meet the requirements. All the raw materials in the melt-blown cloth have a synergistic effect, so that the prepared melt-blown clothis relatively good in filtering efficiency and antibacterial effect, and when the mass ratio of polylactic acid to electret master batch to nano zinc oxide is changed, the filtering performance and antibacterial performance of the melt-blown cloth are reduced.
Owner:ANHUI YUANCHEN ENVIRONMENTAL PROTECTION SCI & TECH

Alginic acid seawater desalination pretreatment technology and preparation of alginic acid compound salt fiber

The invention discloses an alginic acid seawater desalination pretreatment technology and preparation of an alginic acid compound salt fiber. The technology particularly comprises the following steps:dissolving a flocculant, namely alginic acid, in seawater after multiple-effect filtration or mechanical filtration pretreatment, and allowing alginic acid and sodium ions, potassium ions, magnesiumions and calcium ions in the seawater to be bonded via ion exchange and chelation to be precipitated in a form of alginic acid compound salt gel. The alginic acid compound salt fiber is prepared by preparing a fiber from the extracted gel according to a gel fiber-spinning method, and drying the fiber. The technology can effectively reduce a salt content of the seawater in a reverse osmosis membrane seawater desalination technology, alleviates the current high energy consumption situation caused by increase of seawater osmotic pressure and lowers energy consumption cost of the reverse osmosis membrane seawater desalination technology. In addition, the alginic acid compound salt gel precipitated in the seawater desalination pretreatment technology can be prepared into high added value medical alginate dressing, textile fibers and the like by deep processing, and the seawater desalination cost is further lowered.
Owner:MINJIANG UNIV

Bacteriostatic anti-galactorrhea pad

The invention relates to a bacteriostatic anti-galactorrhea pad. The bacteriostatic anti-galactorrhea pad comprises an anti-galactorrhea pad body, and the anti-galactorrhea pad body sequentially comprises an antibacterial skin-friendly layer, an absorption core layer, a breathable bottom film layer and a fixing layer. The absorption core body layer is composed of an absorption layer and a wrapping layer wrapping the absorption layer. When in use, the antibacterial skin-friendly layer is arranged on one side of the skin of a human body, and the bacteriostatic anti-galactorrhea pad can be fixed on clothes of a user through the fixing layer; the antibacterial skin-friendly layer is made of a textile fabric containing chitin fibers; and the wrapping layer is made of a textile fabric sprayed or soaked by a bacteriostatic solution. According to the bacteriostatic anti-galactorrhea pad, the anti-bacterial skin-friendly layer is arranged on one side of the skin of the human body, external bacteria can be isolated and inhibited, the internal wrapping layer is further prepared from the textile fabric sprayed or soaked with the anti-bacterial solution, bacteria in the absorbing layer can be effectively inhibited, so that the bacteriostatic anti-galactorrhea pad and the anti-bacterial skin-friendly layer are matched to achieve the synergistic interaction effect, and the double antibacterial effect is achieved.
Owner:诺宸股份有限公司

Sterility test method for gentamicin sulphate injection

ActiveCN110484596ASterility testSterility testing is accurate and reliableMicrobiological testing/measurementAgainst vector-borne diseasesEscherichia coliPositive control
The invention discloses a sterility test method for a gentamicin sulphate injection. A membrane filtration method is adopted, and the preparation step of a culture involves that a bigeminy closed membrane filter is used for membrane filtration, wherein the flushing amount of a buffer solution is 100-800 mL per membrane, and the addition amount of a culture medium is 100 mL per membrane; the preparation step of a test group involves that the gentamicin sulphate injection is added into a diluent to be diluted, wherein the volume of the diluent is 0-10 times of the volume of the injection; the filtration amount of the injection is 0.8 million of filtering titers per membrane; the preparation step of a positive control group involves that escherichia coli is adopted as positive contrast bacteria, and the positive contrast bacteria are added after the culture medium is added. According to the provided sterility test method for the gentamicin sulphate injection, according to the bacteriostatic characteristic of gentamicin sulphate, the sterility test process, the culture medium, the buffer solution and other elements are adjusted, and the sterility test can be conducted accurately and reliably on the gentamicin sulphate injection.
Owner:甘肃省药品检验研究院
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