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Application of Zukamu granules in preparing medicine for treating virus flu

The technology of wood granules and zucchini is applied to zucchini granules and its application field in the preparation of drugs for treating viral influenza, which can solve problems such as no specific antiviral drugs, and achieve good therapeutic effects, strict structure, Damage reduction effect

Inactive Publication Date: 2017-02-08
新疆维吾尔药业有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Influenza is an acute respiratory infectious disease caused by influenza virus, and there is no specific antiviral drug

Method used

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  • Application of Zukamu granules in preparing medicine for treating virus flu
  • Application of Zukamu granules in preparing medicine for treating virus flu
  • Application of Zukamu granules in preparing medicine for treating virus flu

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Principle: MDCK (dog kidney) cells are used as the virus host, and the degree of inhibition of the virus-induced cytopathic effect (CPE) of the sample is determined.

[0042] 2 Materials and methods:

[0043] 1. Virus strain: Influenza virus A / Hanfang / 359 / 95 (H3N2), cultured and passaged in the allantoic cavity of chicken embryos (2013.9), stored at -80°C.

[0044] 2. Sample treatment: Before the sample is used, DMSO is made into a mother solution, and then diluted 3 times with the culture solution, each with 8 dilutions.

[0045] 3. Blank control drug: Xinjiang Uygur Pharmaceutical Co., Ltd.

[0046] 4. Test method: MDCK cells were inoculated in 96-well culture plate, placed in 5% CO 2 , cultivated at 37°C. Influenza virus 1 / 2 10 after 24 hours -5 , adsorb for 2 hours, discard the virus solution, add the maintenance solution containing samples of different dilutions and blank control drugs, and set up cell control wells and virus control wells at the same time, ...

Embodiment 2

[0056] 1. Principle: MDCK (dog kidney) cells are used as the virus host, and the degree of inhibition of the virus-induced cytopathic effect (CPE) of the sample is determined.

[0057] 2 Materials and methods:

[0058] 1 Virus strain: Influenza virus A / Guangdong Luohu / 219 / 2006 (H1N1), cultured and passaged in the allantoic cavity of chicken embryos (2013.9), stored at -80°C.

[0059] 2. Sample treatment: Before the sample is used, DMSO is made into a mother solution, and then diluted 3 times with the culture solution, each with 8 dilutions.

[0060] 3 Blank control drug: Xinjiang Uygur Pharmaceutical Co., Ltd.

[0061] 4 Test method: MDCK cells were inoculated in 96-well culture plate, placed in 5% CO 2 , cultivated at 37°C. Influenza virus 1 / 2 10 after 24 hours -4 , adsorb for 2 hours, discard the virus solution, add maintenance solutions containing samples of different dilutions and blank control drugs, set up cell control wells and virus control wells, and incubate at 5...

Embodiment 3

[0070] 1. Principle: MDCK (dog kidney) cells are used as the virus host, and the degree of inhibition of the virus-induced cytopathic effect (CPE) of the sample is determined.

[0071] 2 Materials and methods:

[0072] 1 Virus strain: Influenza virus A / Jiangxi Donghu / 312 / 2006 (H3N2), cultured and passaged in the allantoic cavity of chicken embryos (2013.9), stored at -80°C.

[0073] 2. Sample treatment: Before the sample is used, DMSO is made into a mother solution, and then diluted 3 times with the culture solution, each with 8 dilutions.

[0074] 3 Blank control drug: Xinjiang Uygur Pharmaceutical Co., Ltd.

[0075] 4 Test method: MDCK cells were inoculated in 96-well culture plate, placed in 5% CO 2 , cultivated at 37°C. Influenza virus 1 / 2 10 after 24 hours -4 , adsorb for 2 hours, discard the virus solution, add the maintenance solution containing samples of different dilutions and blank control drugs, and set up cell control wells and virus control wells at the same ...

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Abstract

The invention relates to Zukamu granules. The Zukamu granules comprise rhizoma kaempferiae, flower of pygmy waterlily, herba menthae, fructus jujubae, chamomile flower, cordia dichotoma fruit, licorice root, hollyhock seed, radix et rhizoma rhei and pericarpium papaveris; the Zukamu granules are used for treating the virus flu. The Zukamu granules not only have good treating effect on the virus flu, but also can regulate abnormal physique, and is capable of clearing heat, sweating and recuperating energy channels. The Zukamu granules are used for cold and cough, fever without sweat, swollen sore throat and nasal congestion and nasal discharge.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to Zukamu granules and their application in the preparation of medicines for treating viral influenza. Background technique [0002] Influenza viruses belong to the genus Influenzavirus of the family Orthomyxoviridae, and are single-stranded negative-sense RNA viruses with 8 RNA segments. According to the difference in antigenicity of viral nucleoprotein (NP) and matrix protein (M), it can be divided into three types: A (A), B (B) and C (C); The antigenicity of neuraminidase (NA) divides it into different subtypes (HxNy). According to the historical data of influenza epidemics, the antigenicity of influenza B and C viruses is relatively stable; the surface antigens HA and NA of influenza A virus are more likely to mutate. Currently, the influenza virus subtypes circulating in the population are H1N1 and H3N2. [0003] In history, there have been many worldwide influen...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61K9/16A61P31/16
CPCA61K36/906A61K9/16A61K36/185A61K36/28A61K36/30A61K36/484A61K36/534A61K36/62A61K36/66A61K36/708A61K36/725A61K2300/00
Inventor 尹强尹海龙周琴穆丹丹黄璐努尔拉江·帕合尔丁田芳刘腊才宋菲刘秋云王丽敏刘哲
Owner 新疆维吾尔药业有限责任公司
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