Application of combination of furosemide and dexamethasone in treating early severe acute pancreatitis

A technology of acute pancreatitis and dexamethasone, applied in the direction of medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., can solve the problems of aggravating the patient's condition, loss of circulating blood volume, and failure to improve the patient's prognosis, etc., to achieve Effects of reducing complications and death, reducing respiratory distress, and reducing intravenous medication and fluid volume

Inactive Publication Date: 2017-02-15
重庆市万盛经济技术开发区人民医院
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Problems solved by technology

[0005] However, in acute pancreatitis, due to the increase of vascular permeability and the decrease of colloid osmotic pressure, extracellular fluid will penetrate into the peripancreatic space, retroperit

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  • Application of combination of furosemide and dexamethasone in treating early severe acute pancreatitis
  • Application of combination of furosemide and dexamethasone in treating early severe acute pancreatitis

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Embodiment Construction

[0019] The present invention will be described in detail below by taking clinical trials as an example.

[0020] 1. Patient selection criteria: ⑴according to the guidelines for the diagnosis and treatment of severe acute pancreatitis of the Pancreatic Surgery Group of the Surgery Branch of the Chinese Medical Association (the 11th National Symposium on Pancreatic Surgery of the Chinese Medical Association in 2006); Functional insufficiency or systemic diseases affecting cardiopulmonary and renal insufficiency; (3) Exclude patients with biliary obstructive pancreatitis; (4) Exclude patients with hyperlipidemia pancreatitis during pregnancy; (5) Select patients without mental disorders;

[0021] 2. Specific operation method: A total of 24 patients were selected. All patients were fasted and treated with acid suppression according to conventional methods, and then underwent controlled fluid resuscitation, that is, compound sodium chloride was injected intravenously at a crystal-to...

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Abstract

The invention discloses an application of combination of furosemide and dexamethasone in treating early severe acute pancreatitis. In fluid resuscitation, through the application of the combination of the furosemide and and dexamethasone in coordination with natural plasma (human plasma), fluid balance is achieved and parenteral nutrition is supplemented, and meanwhile, capillary leakage is reduced and intra-abdominal hypertension and acute inflammatory reaction are relieved; after the fluid resuscitation, in coordination with parenteral nutrition, early intestinal perfusion is conducted by virtue of a nasal jejunal feeding tube, so as to promote intestinal peristalsis and also to maintain intestinal mucosa nutritional substrate; therefore, the biggest lymph laboratory of human body is kept stable, atrophy and bacterial translocation of the lymph laboratory are relieved, exhaustion and defecation are promoted and abdominal distension is relieved; and in addition, intravenous medication and liquid amount can be obviously reduced, and transformation from fluid balance to negative-water balance is achieved so as to protect organ functions and to relieve the occurrence of complications.

Description

technical field [0001] The invention relates to the treatment of early severe acute pancreatitis, in particular to the application of furosemide combined with dexamethasone in the treatment of early severe acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is a local inflammatory reaction caused by pancreatic self-digestion after the activation of pancreatic enzymes. Clinically, it can be divided into mild acute pancreatitis (MAP) and severe acute pancreatitis. (sever acute pancreatitis, SAP). Among them, severe acute pancreatitis has multiple pathogenesis factors, numerous complications, critical condition, pancreatic hemorrhage and necrosis, and extremely high case fatality rate. [0003] According to the "Severe Acute Pancreatitis Diagnosis and Treatment Draft" drafted by the Pancreatic Surgery Group of the Surgery Branch of the Chinese Medical Association in 2000, the whole course of SAP is divided into 3 phases: (1) Acute reaction phase, from the...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K35/16A61P1/18A61K31/341
CPCA61K31/341A61K31/573A61K35/16A61K2300/00
Inventor 高阳
Owner 重庆市万盛经济技术开发区人民医院
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