Application of [pyr1]‑apelin‑13 as a rescue drug for cardiac arrest caused by long-acting amide local anesthetic poisoning
A technology of cardiac arrest and amide, which is applied in the field of biomedicine to achieve the effect of improving recovery rate and high survival rate
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[0021] The present invention is specifically described below by the embodiment, only for further illustrating the present invention, can not be interpreted as the limitation of protection scope of the present invention, the technical engineer of this field can make some non-essential improvements and improvements to the present invention according to the content of the above-mentioned invention Adjustment.
[0022] This project was approved by the Animal Care and Use Committee of Wenzhou Medical University. Thirty-six Sprague-Dawley male rats, weighing 300-350 g, were provided by the Experimental Animal Center of Wenzhou Medical University. Experiments were performed at Wenzhou Medical University, China.
[0023] [Pyr 1 ]-Apelin-13 was purchased from Tocris Bioscience Company (Tocris Bioscience), and its peptide sequence is Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe, see sequence listing shown. Its technical properties are:
[002...
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