Application of [pyr1]‑apelin‑13 as a rescue drug for cardiac arrest caused by long-acting amide local anesthetic poisoning

A technology of cardiac arrest and amide, which is applied in the field of biomedicine to achieve the effect of improving recovery rate and high survival rate

Active Publication Date: 2018-01-02
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Apelin is not yet a clinical drug, and there is no report on the application of Apelin in the prevention and treatment of bupivacaine cardiotoxicity at home and abroad

Method used

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  • Application of [pyr1]‑apelin‑13 as a rescue drug for cardiac arrest caused by long-acting amide local anesthetic poisoning
  • Application of [pyr1]‑apelin‑13 as a rescue drug for cardiac arrest caused by long-acting amide local anesthetic poisoning
  • Application of [pyr1]‑apelin‑13 as a rescue drug for cardiac arrest caused by long-acting amide local anesthetic poisoning

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Embodiment Construction

[0021] The present invention is specifically described below by the embodiment, only for further illustrating the present invention, can not be interpreted as the limitation of protection scope of the present invention, the technical engineer of this field can make some non-essential improvements and improvements to the present invention according to the content of the above-mentioned invention Adjustment.

[0022] This project was approved by the Animal Care and Use Committee of Wenzhou Medical University. Thirty-six Sprague-Dawley male rats, weighing 300-350 g, were provided by the Experimental Animal Center of Wenzhou Medical University. Experiments were performed at Wenzhou Medical University, China.

[0023] [Pyr 1 ]-Apelin-13 was purchased from Tocris Bioscience Company (Tocris Bioscience), and its peptide sequence is Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe, see sequence listing shown. Its technical properties are:

[0024] Molar mass : 1533.81

[002...

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Abstract

The invention discloses an application of (Pyr<1>)-Apelin-13 as a salvage drug for cardiac arrest caused by long-term amide class local anesthetics toxicity. The technical scheme includes that the salvage drug comprises (Pyr1)-Apelin-13 with the sequence to be: Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe. The application has the advantages that the salvage drug on the basis of the (Pyr<1>)-Apelin-13 can be used for effectively saving cardiac arrest caused by local anesthetic toxicity, and recovery rate is increased; secondary mortality is lower as compared with recognized use of lipid emulsion with epinephrine, and 60-minute survival rate is higher.

Description

technical field [0001] The present invention relates to the field of biomedicine, specifically [Pyr 1 ]-Apelin-13 as a rescue drug for cardiac arrest caused by local anesthetic poisoning. Background technique [0002] Local anesthesia technology is widely used in the fields of clinical anesthesia, acute and chronic pain, and cancer pain treatment. It has the advantages of slight interference to the body's organ function, internal environment, and body metabolism, and its medical cost is low, which is in line with my country's national conditions. Its practical value is relatively protrude. However, the commonly used long-acting amide local anesthetics represented by bupivacaine have prominent cardiotoxicity. Once the blood volume is too large, the ion channels of the heart are blocked, which can cause severe circulatory failure and even cardiac arrest. Routine resuscitation is very difficult, and death High rate. Studies have reported that bupivacaine can inhibit the incre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/10A61P9/00
CPCA61K38/10
Inventor 徐旭仲赵施施夏芳芳陈超星王权光刘乐陈丽梅
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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