Homogenization tank for filling high performance liquid chromatography column, filling device and method
A technology of high performance liquid chromatography and filling device, which is applied to the field of filling high performance liquid chromatography columns with an inner diameter of 0.8 mm to 2.1 mm, and can solve the problems of low filling success rate and the like
Active Publication Date: 2018-06-12
WUXI GALAK CHROMATOGRAPHIC TECH
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Problems solved by technology
[0003] The chromatographic column is the core of high-performance liquid chromatography analysis and separation. The particle size of the filler in the UPLC system is small, and the chromatographic column is relatively thin (with an inner diameter of about 0.8mm to 2.1mm). Influenced by factors such as viscosity, the success rate of filling is low using current filling devices and methods
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[0043] In order to have a clearer understanding of the technical features, purposes and effects of the invention, the specific embodiments of the present invention are now described with reference to the accompanying drawings, in which the same reference numerals represent components with the same or similar structures but the same functions.
[0044] In this article, "schematic" means "serving as an example, example or illustration", and any illustration or implementation described as "schematic" should not be interpreted as a more preferred or more advantageous Technical solutions.
[0045] In order to keep the drawings concise, each drawing only schematically shows the parts related to the present invention, and they do not represent the actual structure and true proportion of the product. In addition, in order to make the drawings concise and easy to understand, in some drawings, only one of the components having the same structure or function is schematically shown, or on...
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Abstract
A homogenate tank filled with a high performance liquid chromatographic column comprises a tank body (10), a first cover body (20), a second cover body (30), a high pressure tube connecting piece (40) and an upper exhaust valve (60). The tank body is provided with a feeding end and a discharging end, and a discharging channel (12) is arranged at the discharging end; the first cover body is arranged at the feeding end of the tank body; the high pressure tube connecting piece traverses through the first cover body, and communicates with the inner cavity of the tank body and a high pressure tube (70) of a high pressure pump, used for being filled; the upper exhaust valve traverses through the first cover body, and one end of the upper exhaust valve is connected with the inner cavity of the tank body; and the second cover body is arranged at the feeding end of the tank body, and communicates with the discharging channel and the high performance liquid chromatographic column. The chromatographic column tube with a minor diameter is filled with a filler homogenate in the homogenate tank under the action of a high pressure, and the filling success rate is high. The invention also provides a filling device and a filling method of the high performance liquid chromatographic column.
Description
technical field [0001] The invention relates to a homogenizing tank, a filling device and a method for filling high-performance liquid chromatography columns, and is especially suitable for filling high-performance liquid chromatography columns with an inner diameter of 0.8 mm to 2.1 mm. Background technique [0002] In the field of micro-analysis and separation, Ultra Performance Liquid Chromatography (UPLC for short) has high resolution and high speed (high resolution) compared with traditional High Performance Liquid Chromatography (HPLC for short). speed) and more environmentally friendly advantages. Silica microspheres with a particle size of only 1.7 μm are often used in UPLC systems, and the inner diameter of the chromatographic column is usually 0.8 mm to 2.1 mm, and the column efficiency ratio is 4.0 mm to 4.6 when filled with silica microspheres with a particle size of 5 μm. mm columns can be 70% higher than columns packed with 3.5μm silica microspheres, which is ...
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IPC IPC(8): G01N30/56
Inventor 罗远驷刘辉穆宁
Owner WUXI GALAK CHROMATOGRAPHIC TECH