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PH sensor for single use equipment

A disposable, sensor technology, applied in specific-purpose bioreactors/fermenters, biochemical equipment and methods, instruments, etc., can solve problems affecting the service life of sensors

Active Publication Date: 2017-02-22
ROSEMOUNT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Exposure to high temperatures, steam and rapid thermal shock can seriously affect sensor life

Method used

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  • PH sensor for single use equipment
  • PH sensor for single use equipment
  • PH sensor for single use equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] There is an emerging need for disposable pH sensors compatible with plastic bag-type, ready-to-use, disposable bioreactors. Many pH sensors based on glass electrodes require protection of the active surface or membrane of the sensor from physical and environmental damage. This function is typically provided by a disposable sleeve or cup that is placed over the sensing end of the pH sensor. However, reusable pH sensors need to be cleaned and sterilized before being used in another bioreactor. Additionally, pH sensors need to be calibrated and stored in buffer solutions to ensure accurate measurements. However, it is desirable to have pH sensors that are compatible with single-use bioreactors.

[0012] Embodiments of the invention generally include a pH sensor configured to be mounted on the wall of a single-use bioreactor having features that allow A mechanical design that stores buffer solution or directs solution around pH sensing and reference elements. However, i...

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PUM

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Abstract

A single use pH sensor housing for a single use container (50) is provided. The single use pH sensor housing includes a compartment configured to house a single use pH sensor (60, 100). In one embodiment, the single use pH sensor housing comprises an actuator configured, when actuated, to transition the single use pH sensor (60, 100) from a storage position to a deployed position. In the storage position, the pH sensor (60, 100) is in fluidic contact with a buffer solution (78). In the deployed position, the single use pH sensor (60, 100) is in fluidic contact with an interior of the single use container (50). During the transition from the storage position to the deployed position, the buffer solution (78) moves from a sensor portion of the compartment to a storage portion (120) of the compartment such that the buffer solution is isolated from contact with the interior of the single use container (50).

Description

Background technique [0001] Disposable equipment replacements offer many advantages to a variety of industries. Typically, such devices do not require cleaning and / or storage after use. Disposable devices can also reduce the machinery needed in industrial plants, such as sterilization equipment is not required. Furthermore, single-use devices only need to be fabricated to undertake a single use, often allowing for alternative, less expensive material constructions. In addition, initial conditions provided by the manufacturer of such devices, such as pre-sterilization, may allow the use of single-use devices without extensive installation time or expense. An example of a single-use device is a single-use container, such as a single-use bioreactor. [0002] Bioreactors are useful for generating and supporting biological reactions for any number of purposes. As a biological reaction process, the reaction itself changes the pH of the solution in the bioreactor. Therefore, mon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34
CPCC12M23/28C12M41/26G01N27/283
Inventor 米歇尔·珍·阿尔曼·阿德金冯昌东
Owner ROSEMOUNT INC