Application of thistlexanthin in the preparation of antiviral drugs

Abstract

The invention relates to the technical field of medicines, in particular to application of cirsimaritin in preparing an antiviral drug. The invention for the first time proposes that the cirsimaritin has definite resistance to an influenza virus. The cirsimaritin can significantly inhibit a cytopathic effect caused by the influenza virus infection, and median inhibitory concentrations to an influenza virus A / FortMonmouth / 1 / 1947 and an influenza virus A / jinnan / 15 / 2009 are equivalent to that of an influenza virus Amantadine and an influenza virus Ribavirin; meanwhile, the cirsimaritin can significantly inhibit the expression of influenza virus specific protein M2 protein, and lower an expression level of influenza virus RNA; the intensities of inhibition functions of 40 microgrammes per milliliter of the cirsimaritin on expression of the influenza virus M2 protein and expression of the influenza virus RNA are equivalent to that of 10 micrometers of the Ribavirin, showing that intensity of the anti-influenza virus effect of the cirsimaritin is close to that of antiviral drugs currently commonly used in clinic, and application of the cirsimaritin in preparing anti-influenza drugs has a good prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the application of thistlexanthin in the preparation of antiviral drugs. Background technique [0002] The morbidity and mortality of viral infectious diseases are very high, and their spread has caused serious social impact and economic losses. Among the many viruses that have been found in humans, influenza is considered to be the most harmful infectious disease so far. It affects a wide range and causes the largest economic loss among infectious diseases. The influenza pandemic that occurs every year around the world seriously affects people's life and work, and even endangers their lives. In recent years, the continuous emergence of new influenza viruses has made human beings face greater threats. Although vaccination is the most effective way to prevent viral infection, influenza virus is not only highly pathogenic, but also highly variable, and humans cannot obtain long-la...

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Problems solved by technology

However, there are no reports about the antiviral effect of thistlexanthin and its application in the preparation of antiviral drugs at home and abroad, and no relevant literature has been retrieved.

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