Ferrocene derivative and preparation method and application thereof

A technology of ferrocene derivatives and drugs, applied in chemical instruments and methods, metallocenes, drug combinations, etc., can solve the problems of poor overall clinical treatment effect and difficult cancer treatment
CN106518933AInactive Publication Date: 2017-03-22XIAMEN INST OF RARE EARTH MATERIALS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAMEN INST OF RARE EARTH MATERIALS
Publication Date
2017-03-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a ferrocene derivative shown as a formula (IA) or a formula (IB) or a pharmaceutically-acceptable salt or a solvate and a medicinal composition thereof. In the formula, R is independently selected from hydrogen, halogen, a cyano-group, a nitro-group, alkyl with 1 to 6 carbon atoms, alkoxy with 1 to 6 carbon atoms, hydroxyl-alkyl with 1 to 6 carbon atoms, halogenated alkyl with 1 to 6 carbon atoms, halogenated alkoxy with 1 to 6 carbon atoms, or alkoxy with 1 to 6 carbon atoms; Z is selected from O, S or NR1; R1 is hydrogen or alkyl with 1 to 6 carbon atoms independently; n is an integer of 0 to 5. The invention further provides a preparation method and medical application of the compound shown as the formula (IA) or the formula (IB) or the pharmaceutically-acceptable salt thereof. The compound has very high restraining activity specific to a lung cancer cell line A549, a colorectal carcinoma cell line HCT116 and / or a breast cancer cell line MCT-7, has broad-spectrum anti-cancer activity, and can be taken as a candidate compound or a lead compound for treating tumor diseases or cancer diseases. The derivative is shown in the description.
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Description

technical field

[0001] The invention belongs to the field of medicine, relates to a class of A and B type ferrocene derivatives with novel structure, and specifically relates to the preparation of the type of ferrocene derivatives, the pharmaceutical composition containing the type of compounds and the use thereof.

[0002] The ferrocene derivatives have strong inhibitory activity on human lung cancer cell line A549, colorectal cancer cell line HCT116 and breast cancer cell line MCF-7. The compounds have broad-spectrum anticancer activities and can be used as candidate drugs or lead compounds for treating diseases such as tumors and cancers. Background technique

[0003] Cancer has become the most important fatal disease in the world, and the mortality rate of cancer patients in developed countries is also high. Cancer can occur in various organs and tissues at any age. The main types of cancer that cause death are: lung cancer, stomach cancer, liver cancer, colon cancer an...

Claims

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