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Method for extracting tanshinone IIA

An extraction method and technology of tanshinone, which is applied in the field of extraction of the target component tanshinone IIA in Danshen medicinal materials, can solve the problems of high explosion-proof requirements for equipment and facilities, low production safety factor, complex process, etc., and achieve targeted separation and safe production and operation The effect of low coefficient and simple process

Inactive Publication Date: 2017-03-22
GUIZHOU JINGFENG INJECTION
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0008] Aiming at the above-mentioned problems in the extraction, purification and refining process of tanshinone ⅡA, ethanol is volatile, the number of extractions is high, the amount of ethanol is large, the requirements for explosion-proof equipment and facilities are high, and the production safety factor is low, as well as the existing supercritical carbon dioxide extraction and refining of tanshinone ⅡA The method process is complicated, the production cost is relatively high and other problems, the invention provides a kind of extraction method of tanshinone IIA

Method used

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  • Method for extracting tanshinone IIA
  • Method for extracting tanshinone IIA
  • Method for extracting tanshinone IIA

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Effect test

Embodiment 1

[0046] The present embodiment provides a kind of extraction method of tanshinone IIA, described method is:

[0047] (1) Grind the salvia miltiorrhiza medicinal material until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure ethanol with a concentration of 95wt% as an entrainer, the amount of the entrainer is 1:6 (W / V), and CO 2 As the extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 32MPa, and the temperature is 60°C; the separation pressure of the first separation tank is 13MPa, and the temperature is 50°C; the separation pressure of the second separation tank is 6MPa, and the temperature is 45°C ; The flow rate of the extractant is 26L / h; the extraction time is 90min; 1 time of supercritical extraction is carried out to obtain the extract;

[0048] (2) Concentrate the extract obtained in step (1) by rotary evaporation at 50° C. to obtain Tanshinone IIA.

[0049] T...

Embodiment 2

[0056] The present embodiment provides a kind of extraction method of tanshinone IIA, described method is:

[0057] (1) Grind the salvia miltiorrhiza medicinal material until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure ethanol with a concentration of 95wt% as an entrainer, the amount of the entrainer is 1:5 (W / V), and CO 2 As the extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 30MPa, and the temperature is 58°C; the separation pressure of the first separation tank is 12MPa, and the temperature is 48°C; the separation pressure of the second separation tank is 6MPa, and the temperature is 43°C ; The flow rate of the extractant is 16L / h; the extraction time is 90min; 1 time of supercritical extraction is carried out to obtain the extract;

[0058] (2) Concentrate the extract obtained in step (1) by rotary evaporation at 50° C. to obtain Tanshinone IIA.

[0059] T...

Embodiment 3

[0066] The present embodiment provides a kind of extraction method of tanshinone IIA, described method is:

[0067] (1) Grind the salvia miltiorrhiza medicinal material until it passes through a 5-mesh sieve, and the moisture content is 2 In the barrel of the extraction device, measure ethanol with a concentration of 95wt% as an entrainer, the amount of the entrainer is 1:10 (W / V), and CO 2 As the extraction agent, set the equipment parameters as follows: the pressure of the extraction tank is 30MPa, and the temperature is 55°C; the separation pressure of the first separation tank is 10MPa, and the temperature is 45°C; the separation pressure of the second separation tank is 6MPa, and the temperature is 40°C ; The flow rate of the extractant is 23L / h; the extraction time is 90min; 1 time of supercritical extraction is carried out to obtain the extract;

[0068] (2) Concentrate the extract obtained in step (1) by rotary evaporation at 50° C. to obtain Tanshinone IIA.

[0069] ...

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Abstract

The invention provides a method for extracting tanshinone IIA, wherein the method comprises the steps: (1) sending a salvia miltiorrhiza medicinal material after pretreatment into a supercritical CO2 extraction device, taking ethanol with the concentration of 90-95 wt% as an entrainer, and carrying out supercritical extraction, to obtain an extract liquid; and (2) carrying out rotary evaporation concentration on the extract liquid obtained in the step (1), to obtain the tanshinone IIA. According to the method, with the ethanol with the concentration of 90-95 wt%, the tanshinone IIA in the salvia miltiorrhiza medicinal material is extracted out to a largest extent at a time through supercritical CO2 extraction, and the extraction rate is relatively high. The method greatly reduces the extraction and separation steps, is simple to operate, can save a lot of organic solvents, and effectively solves the problems of low tanshinone IIA content, low extraction rate, large use amount of ethanol, low production operation safety coefficient, high production cost and the like caused due to more purification refining steps, complex process and incomplete impurity removal.

Description

technical field [0001] The technical field of traditional Chinese medicine extraction of the present invention relates to a method for extracting tanshinone IIA, in particular to a method for extracting tanshinone IIA, a target component of Danshen medicinal material. Background technique [0002] As a traditional Chinese medicine, Salvia miltiorrhiza has the effects of promoting blood circulation, regulating menstruation, removing blood stasis, relieving pain, nourishing the heart and calming the nerves, and its preparations are widely used clinically. Tanshinone is the total ketone extracted from Salvia miltiorrhiza, and it is the main active ingredient. Among them, tanshinone IIA is one of the active ingredients that must be detected in the Chinese Pharmacopoeia. Tanshinone IIA is widely used in industrial fields such as medicine and cosmetics. [0003] Tanshinone IIA, also known as tanshinone Ⅱ or tanshinone ⅡA, has an orange-red needle-like crystal structure, and its s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J73/00
CPCC07J73/003Y02P20/54
Inventor 冯世明马贤鹏毕昌琼罗斌郁华军沈万燕
Owner GUIZHOU JINGFENG INJECTION
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