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Detection reagent kit for detecting MDS (myelodysplastic syndrome)-related gene group

A detection kit and kit technology, applied in the field of molecular biology, can solve problems such as limitations of MDS diagnostic methods, and achieve high detection rate and high detection efficiency

Pending Publication Date: 2017-03-22
天津见康华美医学诊断技术有限公司
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Problems solved by technology

[0007] The purpose of the present invention is to aim at the technical defects of the prior art, and provide a detection kit for detecting MDS-related gene groups, so as to solve the limitation of the diagnostic method of MDS in the prior art and the lack of basis for diagnosing MDS from the perspective of molecular biology

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  • Detection reagent kit for detecting MDS (myelodysplastic syndrome)-related gene group
  • Detection reagent kit for detecting MDS (myelodysplastic syndrome)-related gene group
  • Detection reagent kit for detecting MDS (myelodysplastic syndrome)-related gene group

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[0030] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0031] Materials and methods:

[0032] Among the patients diagnosed from October 2015 to July 2016 at the Hematology Hospital of Chinese Academy of Medical Sciences and Union Medical Diagnostic Center, according to the following criteria, we conducted continuous enrollment (194 patients).

[0033] The inclusion criteria were: patients with myelodysplastic syndrome (MDS) diagnosed by cytomorphology and flow cytometry.

[0034] The diagnostic results of 194 patients are shown in Table 2:

[0035] Table 2 List of patient diagnosis results

[0036]...

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Abstract

The invention discloses a groups of sequencing reagent kits for screening MDS (myelodysplastic syndrome)-related gene mutation and subsequence medical interpretation databases. The MDS-related gene group includes 16 genes of U2AF1, TP53 and the like. The sequencing reagent kits comprise multiple PCR (polymerase chain reaction) primers for amplifying all exons of the 16 MDS-related genes. The sequencing reagent kits and the medical interpretation databases have the advantages that the reagent kits for screening the MDS gene mutation are high in detection efficiency and detection rate and wide in mutant gene coverage; given medical interpretation reports are accurate and authoritative, and the like.

Description

technical field [0001] The invention relates to the technical field of molecular biology, and further relates to a detection kit for screening MDS-related gene mutations and a medical interpretation database thereof, in particular to a detection kit for detecting MDS-related gene groups. Background technique [0002] MDS (myelodysplastic syndrome) is a group of heterogeneous clonal disorders originating from hematopoietic myeloid-committed stem cells or pluripotent stem cells. The main features are ineffective hematopoiesis and high risk of evolving into acute myeloid leukemia. There are varying degrees of abnormal changes in quality and quantity. Its specific clinical manifestations are anemia, which may be accompanied by infection or bleeding, and some patients may be asymptomatic. Some patients may have mild enlargement of liver, spleen, and lymph nodes, and a small number of patients may have sternal tenderness, ribs or joint pain in limbs. The blood picture may show p...

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11
CPCC12Q1/6886C12Q1/686C12Q1/6869C12Q2600/106C12Q2600/118C12Q2600/156C12Q2600/16C12Q2537/143C12Q2535/122
Inventor 贾玉娇寇坤元张冬雷李静
Owner 天津见康华美医学诊断技术有限公司
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