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A kind of absorbable rapid hemostasis material and preparation method thereof

A hemostatic material and absorbent technology, which is applied in the field of absorbable rapid hemostatic material and its preparation, can solve the problems of single function of hemostatic material and unsatisfactory hemostatic effect, achieve better hemostatic effect, overcome fragility, and have good biophase capacitive effect

Active Publication Date: 2020-02-07
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the shortcomings and deficiencies of the hemostatic materials in the prior art, such as single function and unsatisfactory hemostatic effect, the primary purpose of the present invention is to provide an absorbable rapid hemostatic material

Method used

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  • A kind of absorbable rapid hemostasis material and preparation method thereof
  • A kind of absorbable rapid hemostasis material and preparation method thereof
  • A kind of absorbable rapid hemostasis material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Add 0.25g of NaCl and 0.4g of antibacterial agent to 100mL of deionized water to completely dissolve, then add 2g of sodium alginate and stir to obtain mixed solution A, and add solution A according to the water-oil ratio of 1:5 to contain 3% span80 And 1% Tween80 liquid paraffin solution B, 50 ℃ constant temperature water bath, 500 rpm speed of stirring for 15 minutes to obtain mixed solution D, and then according to 1 / 2 (Ca 2+ / Sodium alginate) drop 5% CaCl by volume 2 Solution C, control the dropping speed of 1d / 2s, and continue to react for 45 minutes after the dropping is completed, then add 0.5 times (liquid paraffin) volume of isopropanol to solidify for 15 minutes, centrifuge, wash, and dry to obtain drug-loaded calcium alginate porous microspheres.

[0058] Dissolve 3g sodium carboxymethylcellulose, 1g drug-loaded calcium alginate porous microspheres and 0.5g oyster shell powder in 100mL deionized water, then add 20% (relative to the mass of sodium carboxymethylcell...

Embodiment 2

[0061] Add 1g of sucrose and 0.6g of antibacterial agent to 100mL of deionized water. After it is completely dissolved, add 2g of sodium alginate and stir evenly to obtain mixed solution A. Solution A is added to contain 3% Span80 and 1% according to the water-oil ratio of 1:10 In the isooctane solution of Tween80, stir for 15 min at a constant temperature water bath at 50°C at 500 rpm to obtain a mixed solution D, and then according to 1 / 2 (Ca 2+ / Sodium alginate) drop 5% CaCl by volume 2 Solution C, control the dripping speed for 1d / 2s, wait for the dripping to continue the reaction for 45min, then add 1 times (iso-octane) volume of isopropanol to cure for 15min, centrifuge, wash, and dry to obtain the drug-loaded calcium alginate porous microspheres .

[0062] Add 3g sodium carboxymethylcellulose, 2g drug-loaded calcium alginate porous microspheres and 1g oyster shell powder into 100mL deionized water, then add 20% (relative to the mass of sodium carboxymethylcellulose) glycero...

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Abstract

The invention discloses an absorbable rapid bleeding stopping material and a preparation method thereof. The material comprises medicine carrying calcium alginate porous microspheres, oyster shell powder and sodium carboxymethylcellulose. The medicine carrying calcium alginate porous microspheres and the oyster shell powder have the following two functions: firstly, the medicine carrying calcium alginate porous microspheres and the oyster shell powder serve as a molecular sieve, and can rapidly absorb the water in blood when making contact with the blood, so that visible components in the blood can be rapidly concentrated; secondly, the medicine carrying calcium alginate porous microspheres and the oyster shell powder can release a large number of calcium ions for acting on blood coagulation factors which are concentrated on the material surface, blood coagulation is accelerated, bleeding stopping time is shortened, and the amount of bleeding is reduced. The adopted materials are natural macromolecule polysaccharide and inorganic salt, and the characteristics of good biocompatibility, biodegradability, safety, non-toxicity, absorbability, bleeding stopping ability and the like are achieved. The preparation process is simple, the medicine can be released continuously and steadily within a certain period of time, and the absorbable rapid bleeding stopping material can bring great benefits to the medical field and the society.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to an absorbable rapid hemostatic material and a preparation method thereof. Background technique [0002] At present, the local hemostatic materials used clinically mainly include hemostatic gauze, hemostatic fiber, hemostatic bandage and so on. Since none of these materials are absorbed by the tissue, the hemostasis time is longer and the hemostatic effect is poor. Adhesion to the wound is easy to occur, and the wound is easy to be infected. It is not uncommon to see cases of death due to inability to stop bleeding in time and wound infection. Quick and effective hemostasis can not only relieve the suffering of the injured, but even save a person's life at a critical moment. Some new domestic hemostatic products such as chitosan hemostatic paste, gelatin sponge, collagen sponge hemostatic paste, etc., these products still have poor adhesion to wounds, some have narrow s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/08
CPCA61L24/0005A61L24/001A61L24/0015A61L24/0036A61L24/0073A61L24/08A61L2300/216A61L2300/30A61L2300/404A61L2300/418A61L2300/622A61L2400/04C08L1/286C08L5/04
Inventor 敖宁建王超李普旺李思东杨子明
Owner JINAN UNIVERSITY
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