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Preparation method of Zingiber corallinum Hance effective ingredient nano dosage form with efficient drug-resistant bacteria resistance

An active ingredient, the technology of coral ginger, is applied in the field of preparation of nano-dosage traditional Chinese medicine, which can solve the problems of inability to fully exert pharmacological effects, limit popularization and application, and poor transdermal absorption, so as to prolong drug action time, remove obstacles, and increase penetration. transient effect

Inactive Publication Date: 2017-04-26
GUIZHOU MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since coral ginger oil and terpinen-4-ol, the active ingredients of coral ginger, are not easily soluble in water and poorly absorbed through the skin, it cannot fully exert its pharmacological effects, which limits its popularization and application.

Method used

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  • Preparation method of Zingiber corallinum Hance effective ingredient nano dosage form with efficient drug-resistant bacteria resistance
  • Preparation method of Zingiber corallinum Hance effective ingredient nano dosage form with efficient drug-resistant bacteria resistance
  • Preparation method of Zingiber corallinum Hance effective ingredient nano dosage form with efficient drug-resistant bacteria resistance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Take 45kg of oleic acid, 40kg of polyethylene glycol, 10kg of absolute ethanol, 4.5kg of distilled water, under the condition of ultrasonic or emulsifying machine heating and stirring, slowly add 0.5kg of stearic acid, keep 30~50°C, stir The stearic acid is completely dissolved, and the reaction is stirred and mixed for 30 to 60 minutes, left to stand, and cooled to room temperature to obtain a clear and transparent precursor solution, which is set aside. Take 40kg of the above-mentioned precursor solution, add 10kg of terpinene-4-ol, and stir evenly with ultrasonic waves at room temperature to obtain a nano dosage form of the active ingredient of coral ginger with high efficiency and resistance to drug resistance; take 40kg of the above-mentioned precursor solution, add 10kg of coral ginger oil, and Stir evenly under ultrasonic waves to obtain another nano dosage form of active ingredients of coral ginger with high efficiency and resistance to drug resista...

Embodiment 2

[0029] Embodiment 2: Take 50 kg of oleic acid, 40 kg of polyethylene glycol, 5 kg of absolute ethanol, and 4.5 kg of distilled water. Under the condition of heating and stirring in an ultrasonic wave or an emulsifier, slowly add 0.5 kg of stearic acid, keep at 30-50 ° C, and stir The stearic acid is completely dissolved, and the reaction is stirred and mixed for 30 to 60 minutes, left to stand, and cooled to room temperature to obtain a clear and transparent precursor solution, which is set aside. Take 40kg of the above-mentioned precursor solution, add 10kg of terpinene-4-ol, and stir evenly with ultrasonic waves at room temperature to obtain a nano dosage form of the active ingredient of coral ginger with high efficiency and resistance to drug resistance; take 40kg of the above-mentioned precursor solution, add 10kg of coral ginger oil, and Stir evenly under ultrasonic waves to obtain another nano dosage form of active ingredients of coral ginger with high efficiency and resi...

Embodiment 3

[0030] Embodiment 3: get oleic acid 45kg, polyethylene glycol 10kg, propylene glycol 15kg, ethylene glycol 15kg, dehydrated alcohol 10kg, distilled water 4.5kg, under ultrasonic wave or emulsifying machine heating stirring condition, slowly add stearic acid 0.5kg , keep at 30-50°C, stir the stearic acid to dissolve completely, stir and mix the reaction for 30-60 minutes, let it stand, and cool to room temperature to obtain a clear and transparent precursor solution, which is ready for use. Take 40kg of the above-mentioned precursor solution, add 10kg of terpinene-4-ol, and stir evenly with ultrasonic waves at room temperature to obtain a nano dosage form of the active ingredient of coral ginger with high efficiency and resistance to drug resistance; take 40kg of the above-mentioned precursor solution, add 10kg of coral ginger oil, and Stir evenly under ultrasonic waves to obtain another nano dosage form of active ingredients of coral ginger with high efficiency and resistance t...

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Abstract

The invention discloses a preparation method of a Zingiber corallinum Hance effective ingredient nano dosage form with efficient drug-resistant bacteria resistance. The preparation method is characterized in that oleic acid, stearic acid, polyethylene glycol, propylene glycol, ethylene glycol, absolute ethyl alcohol and distilled water are uniformly mixed firstly, stirred and mixed at 30-50 DEG C for 30-60 min through ultrasonic waves or an emulsifying machine, left to stand and cooled until the solution is clear and transparent, and a precursor solution is obtained; 100 parts of the clear and transparent precursor solution are uniformly mixed with 1-25 parts of terpinene-4-ol and 1-25 parts of Zingiber corallinum Hance oil through ultrasonic treatment, and the Zingiber corallinum Hance effective ingredient nano dosage form with efficient drug-resistant bacteria resistance is obtained.

Description

technical field [0001] The invention relates to a method for preparing two kinds of nano dosage forms of active ingredients of coral ginger with high efficiency and resistance to drug resistance, and belongs to the field of preparation of nano dosage forms of traditional Chinese medicine. Background technique [0002] In recent years, with the complexity of medical activities, nosocomial infections have gradually increased, affecting the quality of medical care and increasing the economic burden on patients. The pathogens causing nosocomial infections are mainly opportunistic pathogenic bacteria. Most of the bacteria isolated from patients with nosocomial infections are drug-resistant, and some are multi-drug resistant. To solve the problem of bacterial resistance, in addition to strengthening the prevention of the abuse of antibacterial drugs, strengthening the monitoring of bacterial resistance and other auxiliary treatment measures, the current research direction focuses ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K31/045A61K9/08A61K47/12A61K47/10A61P31/04A61P33/14A61P31/12
CPCA61K36/9068A61K9/0014A61K9/08A61K31/045A61K47/10A61K47/12
Inventor 康颖倩曾舒曹煜刘见祥
Owner GUIZHOU MEDICAL UNIV
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