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A method for separating ginseng triol type saponins rg1, re and panaxadiol type saponins

A technology of panaxadiol and panaxatriol, which is applied in chemical instruments and methods, glycoside steroids, steroids, etc., can solve the problems of affecting metabolic pathways, complex efficacy, and difficulty in separating the monomer components of ginsenosides. The effect of simple method and low cost

Active Publication Date: 2018-08-24
WUHU ACEGEM BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because ginsenosides affect multiple metabolic pathways, their efficacy is also complex, and the monomer components of various ginsenosides are difficult to separate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for separating panaxadiol type saponins Rg1, Re and panaxadiol type saponins, comprising the following steps:

[0031] 1) Take 100kg of raw ginseng, crush it into 40-60 mesh, put it in a multi-functional extraction tank, add 1000L of water, heat, start timing from boiling, extract for 3 hours, filter, and collect the material liquid; add 800L of water to the filter residue, and heat , start timing from boiling, extract for 2 hours, filter, collect the feed liquid, combine the extracted feed liquid twice, concentrate in vacuum at 60°C, and control the final total liquid-solid content of the feed to 60-70%;

[0032] 2) Transfer the feed liquid to the stirring tank, control the stirring blade rotation speed 35-45r / min, add acetone and ethyl acetate mixed solvent 120L according to the speed of 20-30L / min, wherein acetone: ethyl acetate ratio is controlled at 8: 1. After adding the solvent, continue to stir for 1.5-2 hours, and let stand for 12 hours to precipitate ...

Embodiment 2

[0036] A method for separating panaxadiol type saponins Rg1, Re and panaxadiol type saponins, comprising the following steps:

[0037] 1) Take 100kg of raw ginseng, crush it into 40-60 mesh, put it in a multi-functional extraction tank, add 1000L of water, heat, start timing from boiling, extract for 3 hours, filter, and collect the material liquid; add 800L of water to the filter residue, and heat , start timing from boiling, extract for 2 hours, filter, collect the feed liquid, combine the extracted feed liquid twice, concentrate in vacuum at 60°C, and control the final total liquid-solid content of the feed to 60-70%;

[0038] 2) Transfer the feed liquid to the stirring tank, control the stirring blade rotation speed 35-45r / min, add 200L of acetone and ethyl acetate mixed solvent according to the speed of 20-30L / min, wherein the ratio of acetone: ethyl acetate is controlled at 3: 1. After adding the solvent, continue to stir for 1.5-2 hours, and let stand for 12 hours to pr...

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PUM

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Abstract

The invention provides a method for separating panaxtrol saponin Rg1 and Re from panaxadiol saponin. Compared with the prior art, in the method for separating the panaxtrol saponin Rg1 and Re from the panaxadiol saponin, a mixed solvent of acetone and ethyl acetate serves as a solvent, the panaxtrol saponin Rg1 and Re and the panaxadiol saponin are separated by controlling the dosage ratio of the acetone and the ethyl acetate; in addition, the operation method is simple, and cost is low; and in an obtained product, the content of the panaxtrol saponin Rg1 and Re contained in the panaxadiol saponin is detected to be smaller than 0.5% according to the high performance liquid chromatography.

Description

technical field [0001] The invention belongs to the field of herbal medicine extraction, and in particular relates to a method for separating panaxatriol-type saponins Rg1 and Re from panaxadiol-type saponins. Background technique [0002] Ginseng has been known as the "King of Herbs" since ancient times. It contains a variety of saponins and polysaccharides. The extract can be slowly absorbed by the skin without adverse stimulation. It can expand skin capillaries and promote Skin blood circulation, increase skin nutrition, adjust skin water and oil balance, prevent skin dehydration, hardening, wrinkling, ginseng active substances inhibit the reduction of melanin, make skin white and smooth, enhance skin elasticity, and regenerate cells. The pinnacle of beauty. Soak ginseng directly in 50% glycerin, rub your face with glycerin after 10 days, or decoct ginseng into a thick juice, pour a little into the face wash water every day, rub your face with ginseng-containing glycerin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J17/00
CPCC07J17/005
Inventor 班逢顺汪艳石磊孙凯强万翠芳齐盼雪王会丽
Owner WUHU ACEGEM BIOLOGICAL TECH CO LTD