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Antitumor active part of unicorn lotus and its preparation method and application

A technology of anti-tumor activity and unicornis, which is applied in the directions of anti-tumor drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of high technical requirements, poor operability, etc. Low cost and good inhibitory effect

Active Publication Date: 2021-01-29
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent CN102188564A uses supercritical fluid technology to extract a large amount of anticancer active substances from unicorn lotus, the main components are β-sitosterol and campesterol, and this process requires high requirements and poor operability

Method used

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  • Antitumor active part of unicorn lotus and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Example 1: Slices of fresh unicorn lotus were dried, crushed, 5 kg was taken and added to 50 L of water, heated to slight boiling and extracted twice, each time for 2 hours. Combine and collect the water extracts, add 95% ethanol to adjust the alcohol concentration to 30%, centrifuge to take the supernatant, concentrate under reduced pressure until there is no alcohol smell, and obtain the unicorn lotus water extract; transfer the unicorn lotus water extract into 001×7 On a cation exchange resin column, load the sample and adsorb for 10 hours, collect the sample effluent; wash the resin column with purified water, then elute with 0.5% ammonia water, collect the eluate, concentrate it under reduced pressure and dry it to obtain the intermediate product 1; take the intermediate Product 1 was dissolved in purified water and transferred to a 201×4 anion-exchange resin column, loaded and adsorbed for 16 hours, and the effluent from the loaded sample was collected, concentrate...

Embodiment 2

[0025] Example 2: Slices of fresh unicorn lotus were dried, crushed, 5 kg was taken and added to 50 L of water, heated to a slight boil and extracted 3 times, each time for 2 hours. Combine and collect the water extracts, add 75% ethanol to adjust the alcohol concentration to 30%, centrifuge to take the supernatant, concentrate under reduced pressure until there is no alcohol smell, and obtain the unicorn lotus water extract; transfer the unicorn lotus water extract into 001×7 On a cation exchange resin column, load the sample and adsorb for 16 hours, collect the sample effluent; rinse the resin column with purified water, and then elute with 0.5% ammonia water, collect the eluate, concentrate it under reduced pressure and dry it to obtain the intermediate product 1; take the intermediate Product 1 was dissolved in purified water and transferred to a 201×4 anion-exchange resin column, loaded and adsorbed for 12 hours, and the effluent from the loaded sample was collected, conce...

Embodiment 3

[0026] Example 3: Slices of fresh unicorn lotus were dried, crushed, and 5 kg was added to 50 L of water and heated to a slight boil for extraction 5 times, each time for 2 hours. Combine and collect the water extracts, add 75% ethanol to adjust the alcohol concentration to 30%, centrifuge to take the supernatant, concentrate under reduced pressure until there is no alcohol smell, and obtain the unicorn lotus water extract; transfer the unicorn lotus water extract into 001×7 On a cation exchange resin column, load the sample and adsorb for 12 hours, collect the sample effluent; wash the resin column with purified water, and then elute with 0.5% ammonia water, collect the eluate and concentrate it under reduced pressure, then dry it to obtain the intermediate product 1; take the intermediate Product 1 was dissolved in purified water and transferred to a 201×4 anion-exchange resin column, loaded and adsorbed for 10 hours, collected the sample effluent, concentrated and dried to o...

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Abstract

The invention relates to an anti-tumor active part discovered from the traditional Chinese medicine unicorn lotus and a preparation method. The anti-tumor active site is obtained by sequentially extracting unicorn lotus, separating and purifying with cation exchange resin, and separating and purifying with anion exchange resin. The anti-tumor activity experiment proves that this site has significant anti-tumor activity and has the potential to be developed into a relevant therapeutic drug.

Description

technical field [0001] The invention relates to an anti-tumor active site found in the traditional Chinese medicine unicorn lotus and a preparation method and application of the active site. Background technique [0002] The unicorn lotus (Typhonium giganteum Engl.) is a plant belonging to the genus Typhonium Schott of the family Araceae, and is a unique plant in China. Unicorn lotus is mainly produced in Henan, Sichuan, Shaanxi and other places, and it is also cultivated in various parts of the country. The yield in the Northeast is extremely high, and the price is relatively low. Baifuzi (commonly known as Yubaifu) is the dry tuber of unicorn lotus. "Folk Herbal Medicine" and "Dictionary of Chinese Medicine" record that the bulbs of unicorn lotus are used for medicinal purposes, expelling cold and dampness, dispelling wind and phlegm, suppressing convulsions, treating stroke and phlegm, crooked mouth and eyes, tetanus, treating bruises, and lymphatic tuberculosis . So f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61P35/00
Inventor 张贵民关永霞杜丙源宁停波陈小荣
Owner LUNAN PHARMA GROUP CORPORATION
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