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Method for preparing freeze-dried excipient preparation in any shape and product of method

A technology of freeze-drying shape forming and arbitrary shape, which is applied in the direction of freeze-drying transportation, medical preparations of non-active ingredients, pharmaceutical formulas, etc., and can solve problems such as difficult multi-layer structure, single shape of preparation, single structure of preparation, etc.

Inactive Publication Date: 2017-05-10
董玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the lyophilized excipients on the market are single in form, and the molds used are traditional moulds, i.e. common groove molds. This traditional lyophilized excipient and its preparation method have the following disadvantages:
[0005] (1) The shape of the preparation is single. The reason is that the shape of the mold is fixed, and it can only be demoulded without demoulding or from one direction. No demoulding refers to molding directly in a certain shape of packaging material
[0006] (2) Spherical, ellipsoidal, irregular spherical and other special shapes are rare. Because of the traditional preparation method, it is difficult to make special-shaped freeze-dried excipients
[0007] (3) The prepared tablet has sharp-edged edges, and many tablets with sharp-edged edges obtained after demolding enter the same package together and are prone to abrasion between the sharp-angled edges, resulting in inaccurate drug dosage.
[0008] (4) Because of unidirectional filling, it is difficult to become a multi-layer structure, therefore, the preparation structure is single

Method used

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  • Method for preparing freeze-dried excipient preparation in any shape and product of method
  • Method for preparing freeze-dried excipient preparation in any shape and product of method
  • Method for preparing freeze-dried excipient preparation in any shape and product of method

Examples

Experimental program
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Effect test

Embodiment 1

[0070] (a) add bilberry extract: pullulan = 5:1, add water to prepare a solution, centrifuge and degas, and obtain the stock solution 1 of the freeze-dried excipient;

[0071] (b) Put the lyophilized excipient stock solution 1 into the container 2 to freeze, and cooperate with the agitator 3 to fully stir it into a smoothie-like lyophilized excipient stock solution 12;

[0072] (c) Use a filling pump to fill the smoothie-like freeze-dried excipient stock solution 12 into the one-way release sheet mold 4, and apply a certain pressure to completely fill it in the mold 4 to form a mold with a diameter of 2.5 cm and a thickness of 2.5 cm. The shape of a tablet of 0.5 cm;

[0073] (d) Freeze-drying the mold and the smoothie therein, removing the solvent, to obtain a freeze-dried excipient;

[0074] (f) carry out internal packing, namely obtain cranberry solid instant drink.

Embodiment 2

[0076] (a) stirring rose extract: trehalose = 1:10 to form a solution, and vacuum degassing to obtain a stock solution of a freeze-dried excipient;

[0077] (b) Put the lyophilized excipient stock solution 1 into the container 2 to freeze, and cooperate with the agitator 3 to fully stir it into a smoothie-like lyophilized excipient stock solution 12;

[0078] (c) Use a filling pump to pack the smoothie-like freeze-dried excipient stock solution 12 into a spherical mold 4 consisting of two molds and two-way demoulding, and apply a certain pressure to completely fill it in the mold 4, so that Form the shape of a spherical pellet with a diameter of 3 cm;

[0079] (d) Freeze-drying the mold and the smoothie therein, removing the solvent, to obtain a freeze-dried excipient;

[0080] (e) Carry out internal packaging, and mix with water when using, promptly obtain the ready-to-mix type rose essence skin care product.

Embodiment 3

[0082] (a) Take pullulan: ginseng extract = 3: 1 solution as component one, take PC: Tween 80 = 5: 1 to prepare component two;

[0083] (b) Stirring and preparing solutions 1 and 2 respectively, and centrifugally degassing them to obtain stock solutions 101 and 102 of freeze-dried excipient preparations;

[0084] (c) Put the freeze-dried excipient stock solution 101 into a container 201 to freeze, and fully stir it with the agitator 3 to form a smoothie-like freeze-dried excipient stock solution 121; put the freeze-dried excipient stock solution 102 into the container 202 Freeze, and fully stir with the agitator 3 to form a smoothie-like freeze-dried excipient stock solution 122;

[0085] (d) Using a pipette pump, put the stock solutions 121 and 122 of the smoothie-like freeze-dried excipient preparation into the spherical mold 4 composed of two molds and bidirectional demoulding, and apply a certain external force to connect the two molds, Compress so that it forms the shape...

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Abstract

The invention relates to a method for preparing a freeze-dried excipient preparation in any shape and a product prepared in accordance with the method, and in particular to a preparation method of a freeze-dried excipient preparation which is in any shape and mainly consists of an active ingredient and a binding agent and a product prepared in accordance with the method, wherein the preparation method of the freeze-dried excipient preparation comprises the following steps: fully stirring a freeze-dried excipient preparation stock solution, which is frozen, into ice shavings, and freeze-drying the ice shavings in a certain die.

Description

technical field [0001] The invention relates to a method for preparing a freeze-dried excipient preparation of any shape and a product obtained by the method, in particular to a method for making a smoothie by fully stirring the stock solution of the freeze-dried excipient preparation during freezing, The invention relates to a method for preparing a freeze-dried excipient preparation of any shape, mainly containing active ingredients and binders, which is obtained by filling it into a certain mold for freeze-drying, and the product obtained by the method. Background technique [0002] Freeze-drying excipient technology refers to adding a skeleton support agent and a binder to a flowable liquid, semi-solid or solid active ingredient, or the flowable liquid, semi-solid or solid itself contains a binder and a skeleton The support agent is then poured into a molding mold and shaped by a freeze-drying process. The preparation prepared by the freeze-drying excipient technology is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/44A61K47/42A61K47/38A61K47/36A61K47/34A61K47/32A61K47/10
Inventor 董玲
Owner 董玲
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