Medical adsorbent, and preparation method and applications thereof

A technology of adsorbent and adsorbent carrier, which is applied in the field of medical adsorbent and its preparation, can solve the problems of difficult and effective control of pore size, failure to achieve effective screening of adsorption, poor temperature and pressure resistance, etc., to achieve good biological Compatibility, a wide range of applications, and the effect of improving the ability to withstand pressure and withstand pressure

Active Publication Date: 2017-05-10
GUANGZHOU ENTTEX MEDICAL PROD IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Activated carbon dominated by carbonization technology, such as cellulose, ion exchange resin and other materials, utilizes the porous material formed after carbonization, which has the advantage of forming a high-density microporous structure, but because these materials come from nature, after carbonization It is difficult to effectively control the pore size of micropores, so the adsorption selectivity of substances is poor, and the effective screening of specific molecular adsorption cannot be achieved, so it can only be used in general industrial and civilian products
Usually, ion exchange resin is used for clinical treatment after carbonization, but its selectivity is relatively poor, so it can only be used for emergency patients poisoned by some pesticides
However, the adsorbent carrier made of high-molecular polymers has the difficulty of granulation process, which requires sieving of particles, which will cause a lot of waste, and its microporous structure is unstable, and it has the ability to withstand temperature and pressure. Poor disadvantages, therefore, the effect in clinical application is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0027] In Examples 1-6:

[0028] The carboxymethyl starch ether is prepared from carboxymethyl starch with a higher degree of substitution by etherification reaction of starch and chloroacetic acid under alkaline conditions.

[0029] The hydroxypropyl starch ether is a natural plant raw material, which is a white fine powder obtained through modification, high etherification reaction, and spray drying.

[0030] Described carboxymethyl starch ether and hydroxypropyl starch ether are all white fine powders, can dissolve in cold water, are alkaline pH value 9-11 (3.75% aqueous solution) fineness is less than 350 microns, viscosity is in 400- 1200mpas.

[0031] The molecular weight of the polyethylene glycol is 2000-40000.

Embodiment 1

[0033] 1. Carboxymethyl starch ether, Ca(HCO 3 ) 2 The total mass of powder and RO reverse osmosis water is denoted as A, will account for the carboxymethyl starch ether powder of total mass A 20wt% and account for the Ca(HCO of 65wt% of total mass A 3 ) 2 Powder, fully mixed, and gradually added RO reverse osmosis water accounting for 15wt% of the total mass A, stirred into dough, and placed in the refrigerator to cool down to 5 ° C, stored for 5 hours; Particles with a diameter of 0.5 mm were obtained. When granulating and forming, the temperature was solidified at 80° C., and the obtained particles were carbonized in a carbonization furnace at 160° C. for 4 hours to obtain adsorbent carrier particles.

[0034] 2. preparation of adsorbent solution: the total mass of polysulfone, DMAC, polyethylene glycol and PVP-K30 is recorded as B, and the polysulfone group materials accounting for 8wt% of the total mass B are mixed with the DMAC accounting for 65wt% of the total mass B,...

Embodiment 2

[0038] The difference from Example 1 is:

[0039] Starch ether described in step 1 is hydroxypropyl starch ether and accounts for 30wt%, and described Ca(HCO 3 ) 2 accounts for 70 wt%, and the RO reverse osmosis water accounts for 10 wt%.

[0040] As described in step 1, pellets with a diameter of 0.6 mm were obtained through a sieve using a round pellet granulator.

[0041] The curing temperature described in step 1 is 120°C.

[0042] The power of the ultraviolet light described in step 2 is 80W, the time of the irradiation is 40 minutes, and the time of standing for defoaming is 24h.

[0043]In step 2, the polysulfone family material is 12wt%, the DMAC is 70wt%, the heating temperature is 80°C, the PEG is 10wt%, and the PVP-K90 is 8wt%.

[0044] The spraying amount of the adsorbent solution in step 3 is 20% of the adsorbent carrier particles.

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PUM

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Abstract

The invention discloses a medical adsorbent, and a preparation method thereof. According to the preparation method, particles with a controllable size are manufactured at first, and then the particles are coated by organic substances through spraying, then cured in a bath, cleaned and washed to obtain the medical adsorbent. The obtained adsorbent has the advantages of high pore density, stable structure, and controllable pore size. The pore size of the adsorbent can be adjusted according to the needs, and thus the application range of the adsorbent is wide. The adsorbent has the excellent physical and chemical properties of polysulfone materials, and also has stable hydrophilicity and good blood compatibility. At the same time, the adsorbent has certain strength, the pressure resistant performance of the adsorbent is improved, the applicability in clinic is improved; the specific surface area of the adsorbent is increased, and the adsorption performance of the adsorbent is maximally improved. The adsorbent is encapsulated in a cartridge, and can be widely applied to the field of medical blood purification and adsorption; wherein two ends of the cartridge are both provided with a screen with a controllable pore size.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a medical adsorbent and its preparation method and application. Background technique [0002] Adsorption is an interface phenomenon, which uses the different phases of the two interfaces of the material to form an aggregation of the adsorbed material interface on the adsorption carrier interface, so as to achieve the effect of material separation. It is widely used in industrial and agricultural production. [0003] At present, blood purification and adsorption treatment items in the medical field have been promoted and used clinically. But its effect did not reach the desired effect, mainly because the selection of the substance did not meet the standard. Activated carbon dominated by carbonization technology, such as cellulose, ion exchange resin and other materials, utilizes the porous material formed after carbonization, which has the advantage of fo...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30A61M1/36
CPCA61M1/3692B01J20/20B01J20/262
Inventor尹良红云琛云大信
OwnerGUANGZHOU ENTTEX MEDICAL PROD IND CO LTD