Liver injury and repair type active peptide prepared from tuna offal

A technology of repairing effect and leftovers, applied in the field of active peptides, can solve problems such as the effect and safety of lipid-lowering drugs that need to be studied, and achieve the effects of increasing value, protecting the environment, and avoiding waste

Active Publication Date: 2017-05-10
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The principle of lipid-lowering therapy is the same as that of weight-loss therapy, but the effect and safety of lipid-lowering drugs still need to be studied

Method used

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  • Liver injury and repair type active peptide prepared from tuna offal
  • Liver injury and repair type active peptide prepared from tuna offal
  • Liver injury and repair type active peptide prepared from tuna offal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] 1. Method

[0025] 1.1. Pretreatment of tuna scraps

[0026] Take the fresh tuna leftovers and put the fish meat into distilled water, stir gently, wash away the impurities, homogenate, and store it at -20°C for later use.

[0027] 1.2. Screening of the best enzymes for enzymatic hydrolysis of tuna leftovers

[0028] Using alkaline protease, pepsin, neutral protease, trypsin and papain, the optimum temperature and optimum pH were selected respectively, the enzymolysis time was 6 hours, and the amount of enzyme added was 1000U / g. Carry out enzymatic hydrolysis, enzymatic hydrolysis conditions are as shown in table 1. After the enzymolysis, the enzyme activity was inactivated at 100°C for 10 minutes, and then freeze-dried for later use. The dried product was applied to the model group cells at a concentration of 10 mg / mL for 24 hours, and the protease that reduced the TG content of the model group cells the most was screened out. . The calculation method of TG content...

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Abstract

The invention discloses a liver injury and repair type active peptide prepared from tuna offal. The active peptide is shown as an amino acid sequence of Met-Thr-His-Asp-Asp-Val-Asp-Glu. The active peptide has the advantages that the collagen peptide with the liver injury and repair functions is extracted from an aquatic product processing byproduct, namely tuna offal simply and easily at a low production cost, so that the aquatic product processing byproduct value can be increased remarkably, waste is avoided and environment protection is achieved, and preliminary basis can be provided for related functional food.

Description

technical field [0001] The invention relates to an active peptide, in particular to an active peptide with liver damage repairing effect prepared from tuna leftovers. Background technique [0002] The ocean area accounts for about 71% of the earth's surface, and there are as many as 200,000 species of creatures living in the ocean. It is of great significance to extract and separate effective biologically active substances from marine plants, marine animals and marine microorganisms, and more and more experts and scholars pay attention to extracting effective active substances from marine plants, marine animals and marine microorganisms. At present, the most studied are marine biotoxins, anti-tumor factors, antioxidant factors, and cardiovascular active peptides. Human life is deeply affected by marine toxins, among which poisonous organisms still threaten people's life and production at sea. The marine biological toxins that have been discovered include tetrodotoxin, spina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C12P21/06C07K1/36C07K1/34C07K1/16
CPCC07K7/06C12P21/06
Inventor 丁国芳艾杨洋黄芳芳杨最素李小娟许丹
Owner ZHEJIANG OCEAN UNIV
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