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Cleaning liquid of blood coagulation analysis instrument

A technology of coagulation analyzer and cleaning solution, which is applied in the directions of detergent compounding agent, detergent composition, chemical instrument and method, etc., can solve the problems of environmental impact, high price, etc., and achieves improved accuracy, easy operation, and improved cleaning effect of effect

Inactive Publication Date: 2017-05-10
QINGDAO GUGAO BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the original cleaning solution is expensive and completely dependent on imports
[0003] At present, there are few domestic studies on cleaning solutions used in coagulation analyzers. The Chinese patent document with application number 201410048373.6 discloses a cleaning solution for coagulation analyzers. It first prepares borate buffer solution, and then adds sodium hypochlorite and sodium hydroxide. and alkaline protease, and then use phosphate to adjust the pH value of the solution to 12.4. Although this cleaning solution has a good cleaning effect, it uses phosphate as a pH value regulator, which will affect the environment

Method used

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  • Cleaning liquid of blood coagulation analysis instrument
  • Cleaning liquid of blood coagulation analysis instrument
  • Cleaning liquid of blood coagulation analysis instrument

Examples

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Effect test

Embodiment 1

[0028] Sodium hypochlorite, sodium chloride, anti-oxidative Bacillus subtilis alkaline protease B135, tetrasodium EDTA, fatty alcohol ether sodium sulfate, layered crystal sodium disilicate and water are mixed to prepare a mixed solution, wherein the mass concentration of sodium hypochlorite is 1 %, the mass concentration of sodium chloride is 0.6%, the mass concentration of alkaline protease is 0.3%, the mass concentration of tetrasodium EDTA is 1%, the mass concentration of fatty alcohol ether sodium sulfate is 0.5%, and the mass concentration of layered crystal sodium disilicate is 0.1%. Suction filter the above mixed solution with a 0.2 μm microporous membrane, collect the filtrate as the cleaning solution, and store it in aliquots at 2-8°C for use.

Embodiment 2

[0030] Sodium hypochlorite, sodium chloride, anti-oxidative Bacillus subtilis alkaline protease B135, tetrasodium EDTA, fatty alcohol ether sodium sulfate, layered crystal sodium disilicate and water are mixed to prepare a mixed solution, wherein the mass concentration of sodium hypochlorite is 1 %, the mass concentration of sodium chloride is 0.6%, the mass concentration of alkaline protease is 0.5%, the mass concentration of tetrasodium EDTA is 1%, the mass concentration of fatty alcohol ether sodium sulfate is 1%, and the mass concentration of layered crystal sodium disilicate is 0.5%. Suction filter the above mixed solution with a 0.4 μm microporous membrane, collect the filtrate as the cleaning solution, and store it in aliquots at 2-8°C for use.

Embodiment 3

[0032] Sodium hypochlorite, sodium chloride, anti-oxidative Bacillus subtilis alkaline protease B135, tetrasodium EDTA, fatty alcohol ether sodium sulfate, layered crystal sodium disilicate and water are mixed to prepare a mixed solution, wherein the mass concentration of sodium hypochlorite is 1 %, the mass concentration of sodium chloride is 0.6%, the mass concentration of alkaline protease is 0.4%, the mass concentration of tetrasodium EDTA is 1%, the mass concentration of fatty alcohol ether sodium sulfate is 0.7%, and the mass concentration of layered crystalline sodium disilicate is 0.3%. Suction filter the above mixed solution with a 0.3 μm microporous membrane, collect the filtrate as the cleaning solution, and store it in aliquots at 2-8°C for use.

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Abstract

The invention provides cleaning liquid of a blood coagulation analysis instrument. The cleaning liquid is prepared from sodium hypochlorite with the mass concentration being 1 percent, sodium chloride with the mass concentration being 0.6 percent, alkaline protease with the mass concentration being 0.3 to 0.5 percent, a stabilizing agent with the mass concentration being 1 percent, a surfactant with the mass concentration being 0.5 percent to 1.0 percent, layered crystal sodium disilicate with the mass concentration being 0.05 to 0.5 percent and the balance water. The invention also provides a preparation method of the cleaning liquid of the blood coagulation analysis instrument. In the cleaning liquid provided by the invention, the stabilizing agent, the surfactant and the layered crystal sodium disilicate are used in a matched way, so that the sodium hypochlorite and the alkaline protease can stably exist; in addition, the cleaning effect of the cleaning liquid is improved; in addition, the detection equipment pipeline is effectively cleaned; the accuracy of the detection result is improved. In addition, pH value regulation by phosphates is avoided, so that the environment pollution is avoided.

Description

technical field [0001] The invention relates to the technical field of coagulation analyzer cleaning, in particular to a cleaning solution for a coagulation analyzer. Background technique [0002] At present, most automatic coagulation analyzers are imported, and the matching original cleaning solution is used to clean the sampler and pipeline of the coagulation analyzer to ensure the normal operation of the instrument. However, the original cleaning solution is expensive and completely dependent on imports. [0003] At present, there are few domestic studies on cleaning solutions used in coagulation analyzers. The Chinese patent document with application number 201410048373.6 discloses a cleaning solution for coagulation analyzers. It first prepares borate buffer solution, and then adds sodium hypochlorite and sodium hydroxide. and alkaline protease, and then use phosphate to adjust the pH value of the solution to 12.4. Although the cleaning solution has a good cleaning ef...

Claims

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Application Information

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IPC IPC(8): C11D1/14C11D1/29C11D1/66C11D3/04C11D3/386C11D3/08C11D3/33C11D3/60
CPCC11D1/146C11D1/29C11D1/66C11D3/046C11D3/08C11D3/33C11D3/38618
Inventor 胡小伟王华张辉
Owner QINGDAO GUGAO BIOTECH CO LTD
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