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A novel compound (ks 513) isolated from pseudolysimachion rotundum var. subintegrum, the composition comprising the same as an active ingredient for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof

A technology for allergic diseases and inflammatory diseases, applied in the direction of medical preparations containing active ingredients, organic active ingredients, drug combinations, etc. COPD activity and other issues

Active Publication Date: 2017-05-24
YUNGJIN PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] However, in the literature cited above (the disclosure of which is incorporated herein by reference), there is no information about the extract isolated from Pseudolysimachion rotundum var. subintegrum showing anti-inflammatory activity, antiallergic activity, antiasthma activity and Report or publication of a new compound (KS513) with anti-COPD activity

Method used

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  • A novel compound (ks 513) isolated from pseudolysimachion rotundum var. subintegrum, the composition comprising the same as an active ingredient for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof
  • A novel compound (ks 513) isolated from pseudolysimachion rotundum var. subintegrum, the composition comprising the same as an active ingredient for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof
  • A novel compound (ks 513) isolated from pseudolysimachion rotundum var. subintegrum, the composition comprising the same as an active ingredient for preventing or treating allergy disease, inflammatory disease, asthma or chronic obstructive pulmonary disease and the use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0084] The following reference examples, examples and experimental examples are intended to further illustrate the present invention without limiting its scope.

reference example 1

[0085] Reference example 1. Analyzer

[0086] Melting point was measured by melting point measuring device (Koflermicrohostage) (without correction); optical rotation was measured by Jasco P-1020 polarimeter; UV data was measured by UV-VIS 2450 spectrometer; FT-IR spectrum was measured by Jasco FT / IR-4200 ; NMR spectra were determined by Varian UNITY 400MHz FT-NMR spectrometer using TMS as internal standard; HRESIMS was determined by Waters Q-TOF Premier spectrometer; and HPLC was performed by Gilson HPLC using UV / VIS-155 detector and pump 305 in the experiments analyze.

Embodiment 1

[0087] Example 1: Preparation of new compound (KS513) from Pseudolysimachion rotundum var. subintegrum

[0088] 1-1. Preparation of Crude Extract

[0089] 4.0 kg of dried Pseudolysimachion rotundum var. subintegrum (according to GAP, KRIBB0020697, KRIBB's plant extract bank, cultivated in Soi-myeon Eumseong-gun Chungcheongbuk-do, 244, Korea; Taejeon, Korea) was cut into small pieces, and mixed with 10 L methanol mixture. The mixture was stirred at room temperature for 24 hours and extracted twice at 78° C. under reflux for 12 hours to collect the filtrate. Filter the extract with filter paper to remove residue. The collected filtrate was concentrated by a rotary evaporator (EYELA, N-2100, Japan) at 55°C-65°C under reduced pressure, and dried with a freeze dryer to obtain 397.4 g of dried crude extract.

[0090] 1-2. Preparation of purified extract

[0091] 200 g of the dried crude extract was dissolved in a mixed solvent (25% MeOH-water) and further purified by using prepa...

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PUM

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Abstract

The present invention relates to a novel (1aS,1bS,2S,4S,5aR,6S,6aS)-1a-(hydroxymethyl)-4-methoxy-2-(((2S,3R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-6-yl 4-hydroxybenzoate} (KS-513), the isomer thereof, the pharmaceutically acceptable salt or solvates thereof, a composition comprising the same as an active ingredient for preventing or treating allergic disease, inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD) and the use thereof.

Description

technical field [0001] The present invention relates to: a new compound (KS513) isolated from Pseudolysimachion rotundum var. subintegrum, compositions containing the compound for preventing or treating allergic diseases, inflammatory diseases, asthma or chronic obstructive pulmonary disease and their uses. Background technique [0002] In general, an inflammatory response is a normal response of the human body associated with edema, pain, etc. in case of any infection of a tissue or cell causing some organic change of the tissue or cell. Recently, various types of cytokines have been found to be involved in inflammatory diseases. [0003] Allergic reactions can be divided into four categories according to the type of response, namely, type I, type II, type III, and type IV, or according to the type of time period from the time of resensitization caused by the allergen to the time of onset of the reaction. Sexual reactions are divided into two categories, namely, immediate ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04A61K31/7048A61P29/00A61P11/06A61P11/00A23L33/105
CPCC07H17/04A23V2002/00A23V2200/30A23V2200/314A23V2250/21A61K36/80C07H17/08A61K9/0019A61K47/02A61K9/0095A61K9/2018A61K9/2059A61P11/06A61P37/08A61P11/00A61P29/00A61K31/7048A23L29/206A61P27/14A23L33/30A23L33/105
Inventor 李容男柳志石申大熙柳炳焕吴世湸安境燮李炯圭李洙义宋赫桓柳亨杬
Owner YUNGJIN PHARM CO LTD