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Green and environment-friendly solid dispersion taking porous starch as carrier and preparation method thereof

A technology of solid dispersion and porous starch, which is applied in the field of medicine and achieves the effects of improved solubility, better in vitro dissolution, and easy mass preparation

Inactive Publication Date: 2017-05-31
南京福科帝生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the solubility of insoluble drugs in existing solid dispersions needs to be further improved

Method used

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  • Green and environment-friendly solid dispersion taking porous starch as carrier and preparation method thereof

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preparation example Construction

[0036] Another aspect of the embodiments of the present invention provides a method for preparing the aforementioned green solid dispersion with porous starch as a carrier, including:

[0037] Provide porous starch;

[0038] The porous starch is uniformly mixed with the drug components, and the drug components are evenly distributed on the surface and pores of the porous starch to form the green and environment-friendly solid dispersion with the porous starch as the carrier.

[0039] As one of the preferred embodiments, the mass ratio of the porous starch to the pharmaceutical ingredient is 4:1-12:1.

[0040] Preferably, the porous starch is prepared by a composite enzyme method.

[0041] Further, the drug ingredients include poorly soluble drugs, such as andrographolide.

[0042] As one of the preferred embodiments, the preparation method includes: mixing the porous starch and the insoluble drug uniformly in a mass ratio of 4:1 to 12:1, and then adding distilled water whose...

Embodiment 1

[0057] The preparation method of the andrographolide solid dispersion of the present embodiment is as follows:

[0058] Mix the porous starch as the carrier with andrographolide in a mass ratio of 4:1, then add water with a quality of 100% of the porous starch and stir evenly, and place the mixture in a grinder for grinding, wherein the parameters of the grinder are: The rotation speed is 200r / min, the ball-to-material ratio is 2:1, the ball milling time is 1h, and the filler rate is 10%. The solid obtained after grinding is dried, ground, sieved, and tabletted to obtain a solid dispersion of andrographolide.

[0059]Solubility evaluation experiment: according to the first method of dissolution measurement (basket method), with 0.2% SDS 900mL as the dissolution medium, the rotating speed is 100r / min, and 5 tablets (known content) of the andrographolide solid dispersion of the present embodiment are taken Place them in the rotating baskets respectively, and take 8 mL samples a...

Embodiment 2

[0063] The preparation method of the andrographolide solid dispersion of the present embodiment is as follows:

[0064] Carrier porous starch and andrographolide are mixed evenly in a mass ratio of 12:1, then add water with a quality of 120% of the porous starch quality and stir evenly, and place the mixture in a grinder for grinding, wherein the parameters of the grinder are: the speed is 500r / min, the ball-to-material ratio is 8:1, the ball milling time is 4h, and the filler rate is 35%. The solid obtained after grinding is dried, ground, sieved, and tabletted to obtain a solid dispersion of andrographolide.

[0065] Solubility evaluation experiment: according to the first method of dissolution measurement (basket method), with 0.2% SDS 900mL as the dissolution medium, the rotating speed is 100r / min, and 5 tablets (known content) of the andrographolide solid dispersion of the present embodiment are taken Place them in the rotating baskets respectively, and take 8 mL samples...

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Abstract

The invention discloses a green and environment-friendly solid dispersion taking porous starch as a carrier and a preparation method thereof. The green and environment-friendly solid dispersion comprises porous starch and drug components, wherein the porous starch is used as the carrier; the drug components are uniformly distributed in the surface and the pores of the porous starch; the mass ratio of the porous starch to the drug components is (4 to 1)-(12 to 1). The preparation method of the solid dispersion comprises the step of uniformly distributing the drug components in the surface and the pores of the porous starch through physical and mechanical force to form the green and environment-friendly solid dispersion taking the porous starch as the carrier. Through the green and environment-friendly solid dispersion, the solubility of insoluble drugs can be effectively improved; the in-vitro solubility of the insoluble drugs is more excellent; the green and environment-friendly solid dispersion has the advantages of uniform dispersion and high stability, is green and environmentally friendly, and is easy to realize industrialization.

Description

technical field [0001] The invention relates to a solid dispersion, in particular to an environmentally friendly solid dispersion which can improve the solubility of insoluble drugs and uses porous starch as a carrier and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Porous starch, also known as microporous starch, is a hollow starch with a porous surface formed by artificially processing various raw starches. Porous starch is a new type of adsorption material that has developed rapidly in recent years. Due to its wide source of raw materials, simple and easy preparation process, good adsorption performance, safety and environmental protection, porous starch is widely used in various fields such as medicine, food and daily chemical industry. There are a wide range of applications. At present, the preparation methods of porous starch mainly include: physical methods (ultrasonic irradiation, spray), mechanical method...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/36A61K31/365C12P19/04
CPCA61K9/146A61K31/365C12P19/04
Inventor 姚卫蓉
Owner 南京福科帝生物科技有限公司
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