Macleaya cordata-scutellaria baicalensis composition for veterinary drugs or drug feed additives and application of macleaya cordata-scutellaria baicalensis composition

A feed additive, Boluohui technology, which is applied in the field of Boluohui, can solve the problems of animal autoimmunity decline, pathogenic adaptive variation, bacterial drug resistance increase, etc., and achieve the improvement of animal growth performance, small side effects, and easy access Effect

Inactive Publication Date: 2017-05-31
MICOLTA BIORESOURCE INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The abuse of feed antibiotics in the breeding industry has affected the balanced microbial environment in nature, resulting in adaptive variati

Method used

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  • Macleaya cordata-scutellaria baicalensis composition for veterinary drugs or drug feed additives and application of macleaya cordata-scutellaria baicalensis composition
  • Macleaya cordata-scutellaria baicalensis composition for veterinary drugs or drug feed additives and application of macleaya cordata-scutellaria baicalensis composition
  • Macleaya cordata-scutellaria baicalensis composition for veterinary drugs or drug feed additives and application of macleaya cordata-scutellaria baicalensis composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] In this experiment, the powder of the above-ground non-fruit parts of Rhizoma baicalensis (including the above-ground parts of Rhizoma rhizomes before flowering and the non-fruit parts of Rhizoma baicalensis after flowering) or its extracts were combined with Scutellaria baicalensis powder or its extracts. Recipe, then measure the content of N-p-coumaryl tyramide and baicalin in its composition, the ratio and content range of each composition are shown in the following table 1

[0041] Table 1 The content ranges of N-p-coumaryl tyramide and baicalin in each composition

[0042]

Embodiment 2

[0044] In vitro inhibition test of Boluohui extract, Scutellaria baicalensis extract and Boluohui-Scutellaria baicalensis combination extract on common pathogenic bacteria in livestock and poultry.

[0045] Choose Boluohui extract (N-p-coumaryl tyramide 0.01%), Scutellaria baicalensis extract (baicalin 1%) and Boluohui-scutellaria baicalensis extract (N-p-coumaryl tyramide 0.01%, baicalin 1%) , the extract was prepared into a solution of equal concentration, and then the in vitro antibacterial tests were carried out on common animal pathogenic bacteria such as Staphylococcus gallinarum, Salmonella pullorum, Salmonella choleraesuis, Escherichia coli and Staphylococcus aureus. According to the aseptic operation procedure, under aseptic conditions, dump the medium plate corresponding to the corresponding strain, and apply the corresponding strain inoculum on it. Paper and tablet are tightly bonded. Three copies of each sample were made, and the results were averaged. Invert cul...

Embodiment 3

[0055] Effect of Boluohui-Scutellaria baicalensis group extract (0.01% N-p-coumaryl tyramide, 1% baicalin) on diarrhea in mice induced by Escherichia coli

[0056] 40 ICR mice, half male and half male, were randomly divided into 5 groups according to sex and body weight, 8 mice in each group, respectively model control group, sulfasalazine group, Boluohui-Scutellaria baicalensis extract low, medium, and In the high-dose group, the mice in each group were intragastrically administered the corresponding drug solution at 0.2mL / 10g, once a day, for 3 consecutive days, and the mice in the model control group were intragastrically administered an equal volume of 0.5% CMC-Na . 30 minutes before the last administration, mice in each group were injected intraperitoneally with 0.6 mL / only 6×10 9 coli solution per mL, observed continuously for 4 hours after injection, and recorded the time of the first loose stool after intraperitoneal injection of Escherichia coli, the diarrhea rate an...

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Abstract

The invention discloses a macleaya cordata-scutellaria baicalensis composition for veterinary drugs or drug feed additives and an application of the macleaya cordata-scutellaria baicalensis composition. The macleaya cordata-scutellaria baicalensis composition comprises a macleaya cordata over-ground non-fruit part (comprising a macleaya cordata over-ground part before blooming and a macleaya cordata over-ground part after blooming) and/or a macleaya cordata over-ground non-fruit part extract, and scutellaria baicalensis and/or a scutellaria baicalensis extract. The composition is applied to preparing veterinary drugs which have anti-inflammatory, bacteriostatic, anti-stress and diarrhea prevention functions, or preparing drug feed additives which are used for prompting the animal growth or improving the feed conversion or improving the animal growth performance; the veterinary drugs or the drug feed additives are good in effect of treating the digestive tract diseases of animals and dairy cow mastitis, and have relatively good functions of resisting stress, resisting inflammation, protecting intestinal health and improving the animal growth performance; and the composition is wide in raw material source and low in cost, is capable of realizing the comprehensive utilization of resources, and is worthy of popularization and application.

Description

technical field [0001] The present invention relates to a composition of Macleaya cordata (Willd) R.Br. and Scutellaria baicalensis Georgi, wherein Macleaya cordata (Macleaya cordata (Willd) R.Br.) comprises Macleaya microcarpa (Maxim.) Fedde ), particularly relates to a kind of Boluohui aboveground non-fruit part and / or Boluohui aboveground non-fruit part extract, and the application of Scutellaria baicalensis and / or Scutellaria baicalensis extract composition in veterinary medicine or animal medicine feed additive, belonging to the field of veterinary medicine . Background technique [0002] The abuse of feed antibiotics in the aquaculture industry has affected the balanced microbial environment in nature, resulting in adaptive variation of pathogens, increased bacterial resistance, and decreased animal autoimmunity, frequent disease and reduced feed intake. [0003] The food safety problems caused by the use of antibiotics in feed have attracted widespread attention from...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P31/04A61P39/00A61P15/14A61P1/12A23K10/30A61K36/539
CPCA61K36/66A61K36/539A61K2300/00
Inventor 曾建国唐昭山任芬芬陈燕乐
Owner MICOLTA BIORESOURCE INC LTD
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