Molecular traditional Chinese medicine sustained-release tablet for resisting bone mass loss and preparation method thereof

A technology of sustained-release tablets and traditional Chinese medicines, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. High bioavailability and excellent curative effect

Active Publication Date: 2017-05-31
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main drugs of Western medicine for postmenopausal osteoporosis are bone resorption inhibitors (estrogen, calcitonin, isoflavones, etc.), bone formation d

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A molecular traditional Chinese medicine sustained-release tablet for anti-bone loss and a preparation method thereof. The molecular traditional Chinese medicine sustained-release tablet includes molecular traditional Chinese medicine components and pharmaceutically acceptable adjuvant components. 5 parts of chastity seed), 5 parts of weedule lactone (Eclipta japonica), 2 parts of paeoniflorin (Paeonia officinalis), 3 parts of psoralen (psoralen), 5 parts of diosgenin (yam); the ingredients of the excipients It is 30 parts of sodium alginate, 1 part of carbomer (934), 25 parts of hydroxypropyl methylcellulose, 20 parts of lactose, and 4 parts of magnesium stearate.

[0021] Described preparation method comprises the following steps:

[0022] (1) Weigh each molecule of traditional Chinese medicine ingredients in proportion and mix them evenly;

[0023] (2) Sodium alginate and hydroxypropyl methylcellulose are used as the skeleton material, and carbomer (934) is added as...

Embodiment 2

[0026] A molecular traditional Chinese medicine sustained-release tablet for anti-bone loss and a preparation method thereof. The molecular traditional Chinese medicine sustained-release tablet includes molecular traditional Chinese medicine components and pharmaceutically acceptable adjuvant components. Sedum chinensis) 2.5 parts, wedelolide (Eclipta chinensis) 2.5 parts, paeoniflorin (Paeonia officinalis) 1 part, psoralen (psoralen) 2 parts, diosgenin (yam) 2 parts. The excipients are 40 parts of sodium alginate, 3 parts of carbomer (934), 15 parts of hydroxypropyl methylcellulose, 30 parts of lactose and 2 parts of magnesium stearate.

[0027] Described preparation method comprises the following steps:

[0028] (1) Weigh each molecule of traditional Chinese medicine ingredients in proportion and mix them evenly;

[0029] (2) Sodium alginate and hydroxypropyl methylcellulose are used as the skeleton material, and carbomer (934) is added as the binder, then mixed with the mo...

Embodiment 3

[0032] A molecular traditional Chinese medicine sustained-release tablet for anti-bone loss and a preparation method thereof. The molecular traditional Chinese medicine sustained-release tablet includes molecular traditional Chinese medicine components and pharmaceutically acceptable adjuvant components. 1.5 parts of chastity seed), 1.5 parts of weedule lactone (Eclipta chinensis), 0.5 parts of paeoniflorin (Paeonia officinalis), 0.5 parts of psoralen (psoralen), 1 part of diosgenin (yam). The excipients are 45 parts of sodium alginate, 2 parts of carbomer (934), 20 parts of hydroxypropyl methylcellulose, 25 parts of lactose and 3 parts of magnesium stearate.

[0033] Described preparation method comprises the following steps:

[0034] (1) Weigh each molecule of traditional Chinese medicine ingredients in proportion and mix them evenly;

[0035] (2) Sodium alginate and hydroxypropyl methylcellulose are used as the skeleton material, and carbomer (934) is added as the binder, ...

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Abstract

The invention relates to a molecular traditional Chinese medicine sustained-release tablet for resisting bone mass loss and a preparation method thereof. The molecular traditional Chinese medicine sustained-release tablet comprises molecular traditional Chinese medicine ingredients and pharmaceutically allowed auxiliary material ingredients, wherein the molecular traditional Chinese medicine components comprise 1-5 parts of specnuezhenide (ligustrum lucidum), 1-5 parts of wedelolactone (eclipta prostrata), 0.5-3 parts of paeoniflorin (peony), 0.5-3 parts of psoralen (psoralea corylifolia), and 1-5 parts of diosgenin (yam) ]; and the auxiliary material ingredients comprise 10-50 parts of sodium alginate, 1-5 parts of carbomer (934) , 10-30 parts of hydroxypropyl methyl cellulose, 10-40 parts of lactose, and 1-5 parts of magnesium stearate. Based on a theory of Chinese medicine and a theory of sustained-release preparations, Chinese medicine pathological features of postmenopausal osteoporosis, and scientific compatibility, the molecular traditional Chinese medicine sustained-release tablet which is safe and reliable, high in bioavailability and significant in curative effect is developed.

Description

technical field [0001] The invention relates to a molecular traditional Chinese medicine sustained-release tablet for anti-bone loss and a preparation method thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Postmenopausal osteoporosis is a disease related to age, which belongs to the category of "bone impotence" in traditional Chinese medicine. It occurs in postmenopausal women. Due to the lack of estrogen, it causes a bone metabolic disease characterized by impaired bone strength, resulting in a risk of fracture. The pathological feature is that the bone mineral content and bone matrix components decrease in proportion, the cortical bone becomes thinner, and the trabecular bone becomes thinner and less. With the aging of the population, the incidence rate has increased significantly, and it has become a public problem that seriously affects the health and quality of life of the elderly, and it is also one of the hot is...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/22A61K47/38A61P19/10A61P15/12A61K31/7048A61K31/37A61K31/58
CPCA61K9/0002A61K9/2054A61K31/37A61K31/58A61K31/7048A61K36/28A61K36/487A61K36/638A61K36/65A61K36/71A61K36/8945A61K2300/00
Inventor 梁文娜李西海曾建伟李灿东
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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