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Modified annular polypeptide PV, application of annular polypeptide PV and antibacterial preparation

A cyclic, preparation technology, applied in antibacterial drugs, medical preparations containing active ingredients, peptides, etc., can solve the problem of unclear antiviral mechanism of ALF

Active Publication Date: 2017-05-31
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of ALF antiviral action is still unclear

Method used

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  • Modified annular polypeptide PV, application of annular polypeptide PV and antibacterial preparation
  • Modified annular polypeptide PV, application of annular polypeptide PV and antibacterial preparation
  • Modified annular polypeptide PV, application of annular polypeptide PV and antibacterial preparation

Examples

Experimental program
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Embodiment Construction

[0021] The present invention is described in further detail below in conjunction with embodiment.

[0022] A chemically synthesized shrimp cyclic polypeptide PV with obvious antibacterial activity, their sequence and source sequence information are as follows:

[0023] (1) Information of SEQ ID No.1

[0024] (a) Sequential features

[0025] * Length: 16 amino acids

[0026] *Type: amino acid

[0027] * Chain type: single chain

[0028] *Topology: ring, disulfide bond formed between two cysteines

[0029] *Space structure: Two cysteines are connected by disulfide bonds to form a ring structure with figure 1 The spatial structure shown: the polypeptide sequence forms two connected β-sheet structures.

[0030] (b) Molecule type: protein

[0031] Sequence description:

[0032] SEQ ID No.1

[0033] Ac-c(CKPKFKRWKLKFKKWC)-NH 2

[0034] Among them, the amino acid in brackets is a ring-forming amino acid, and the lowercase c on the left side outside the brackets indicates t...

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Abstract

The invention relates to an annular synthetic polypeptide PV and antibacterial application thereof. The annular synthetic polypeptide PV provided by the invention has the amino acid sequence and structure features shown as SEQ ID No.1 in a sequence list; the annular synthetic polypeptide PV is derived from LBDv active peptide shown as the SEQ ID No.2 in the sequence list. The annular synthetic polypeptide PV is subjected to biological function in vitro verification; the verification proves that a good effect of inhibiting the growth or multiplication of gram-positive bacteria and gram negative bacteria is realized.

Description

technical field [0001] The invention relates to a cyclic synthetic polypeptide PV and its antibacterial application, in particular to a synthetic structurally modified cyclic polypeptide derived from LBDv active polypeptide and its antibacterial application. Background technique [0002] Shrimp farming occupies an important position in my country's aquaculture industry. In recent years, the disease problems in the shrimp farming process have seriously hindered the healthy development of its farming production. The abuse of antibiotics and the deterioration of the environment have made it difficult for marine animals to suffer from diseases. fundamentally under control. [0003] Antimicrobial peptides (proteins) are considered to be important effector molecules for fish, shrimp, and shellfish to defend against infections caused by exogenous pathogens such as bacteria and viruses, and play an important role in the innate immunity of animals. There are many kinds of antimicrobi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/435A61K38/10A61P31/04
CPCA61K38/00C07K14/43509Y02A50/30
Inventor 李诗豪李富花相建海
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI