An electrospun nanofiber with drug radial isolation distribution characteristics and preparation method thereof

A technology of distribution characteristics and drugs, applied in the field of materials science, can solve the problems of poor sustained and controlled release performance, single nanofiber structure, etc., and achieve the effect of clear three-layer structure, simple preparation process and small nanometer diameter.

Inactive Publication Date: 2019-08-30
UNIV OF SHANGHAI FOR SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the above-mentioned technical problems in the prior art, the present invention provides an electrospun nanofiber with the characteristics of radially isolated distribution of drugs and a preparation method thereof, the electrospun nanofiber with the characteristics of radially isolated distribution of drugs The preparation method thereof shall solve the technical problems that the structure of nanofibers in the prior art is single, and the sustained and controlled release performance of loaded drugs is not good.

Method used

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  • An electrospun nanofiber with drug radial isolation distribution characteristics and preparation method thereof
  • An electrospun nanofiber with drug radial isolation distribution characteristics and preparation method thereof
  • An electrospun nanofiber with drug radial isolation distribution characteristics and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Example 1 Implementation of three-stage coaxial electrospinning process

[0025] Put 66 grams of ethyl cellulose into 300 grams of ethanol to make a mother liquor with good spinning properties. Divide the above mother liquor into three parts, add 5 grams, 0 grams and 5 grams of ibuprofen respectively, and stir to form a transparent eutectic solution, which is used as the working fluid of the inner layer, the middle layer and the outer layer respectively. Put the above three working fluids into the injectors 10, 9, and 8 of the inner layer, middle layer, and outer layer working fluid of the three-stage coaxial electrospinning respectively, and connect the fluids of each layer to the three-stage coaxial spinning head 5; Connect the three-stage coaxial spinning head 5 and the high-voltage electrostatic generator 1. The three-stage coaxial high-voltage electrospinning process was implemented according to the following process conditions and parameters: the fluid flow rate ...

Embodiment 2

[0027] Example 2 Characterization and analysis of the morphology and structure of nanofibers with drug radial isolation distribution characteristics

[0028] Field scanning electron microscopy (FESEM) was used to observe the surface of the fiber prepared in Example 1 after spraying gold, and the results were as follows image 3 shown. The prepared fiber exhibits a good linear state, no beading structure occurs, the fiber surface is smooth, and the fiber accumulation is uniform. The diameter is 570 ± 120 nm, the distribution is relatively uniform, and the diameter distribution is relatively concentrated.

[0029] The internal structure of the prepared fiber was observed by high-resolution transmission electron microscope (TEM), and the results were as follows: Figure 4 As shown, the inner / middle / outer three-layer structure of the nanofibers is clear, and the middle layer presents lower grayscale characteristics due to less drug content.

[0030] Such as Figure 5 As shown,...

Embodiment 3

[0031]Example 3 Sustained and controlled release performance of ibuprofen provided by nanofibers with drug radial isolation distribution characteristics

[0032] According to the 2015 edition of Chinese Pharmacopoeia Appendix ⅩD Release Test Method 2, the RCZ-8A intelligent dissolution tester was used to conduct the in vitro dissolution test on the drug-loaded nanofibers obtained above. The control speed is 50rpm, and the temperature is 37±0.1°C. In the first 2 hours, 900 mL of artificial gastric juice without enzymes was used as the dissolution medium, and 900 mL of artificial intestinal juice (pH6.8 phosphate buffer solution) without enzymes was used as the dissolution medium later to investigate the properties of nanofibers with drug radial isolation distribution characteristics. Controlled drug release properties in vitro. Sampling 5mL at the scheduled time, filtering through a 0.22µm microporous membrane to obtain a sample of the eluate, and immediately replenishing the ...

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Abstract

The invention provides a drug-loaded nanofiber with a radial discontinuous drug distribution characteristic. The drug-loaded nanofiber comprises an inner core layer, wherein a middle layer is arranged at the periphery of the inner core layer; an outer surface layer is arranged at the periphery of the middle layer; the inner core layer, the middle layer and the outer surface layer coaxially stretch; drugs in the fiber are radially distributed discontinuously; and the inner core layer and the outer surface layer contain the drugs. The invention further provides a preparation method of the drug-loaded nanofiber. The preparation method comprises the steps that a spinnable polymer solution is prepared into a mother solution; the drugs are added to the mother solution to form an inner core layer working fluid and an outer surface layer working fluid; the inner core layer working fluid and the outer surface layer working fluid are respectively packed into an inner core layer fluid injector and an outer surface layer fluid injector; a middle layer fluid injector is filled with the mother solution; the inner core layer fluid injector, the middle layer fluid injector and the outer surface layer fluid injector are respectively connected with three injection pumps; injection rates of the three fluid layers in a three-stage coaxial spinning head are respectively controlled by the three injection pumps; and the nanofiber with the radial discontinuous drug distribution characteristic is prepared by the action of high-voltage static. The nanofiber prepared by the method is clear in structure, small in nano diameter and good in linearity.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a nanofiber, in particular to an electrospun nanofiber with the characteristics of radial isolation and distribution of drugs and a preparation method thereof. Background technique [0002] High-voltage electrospinning technology (electrospinning) is a top-down nano-manufacturing technology. The jet formed by overcoming the liquid surface tension and viscoelastic force of the droplet at the tip of the nozzle is overcome by an external electric field force. Under the joint action of Coulomb force and surface tension, the atomized liquid jet is bent, stretched, and split by high frequency, and is stretched tens of millions of times within tens of milliseconds. After the solvent is volatilized or the melt is cooled, it is obtained at the receiving end. nanoscale fibers. This technology has simple process, convenient operation, wide selection of materials, and strong controllability. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F8/02D01F1/10A61K9/70A61K31/192A61K47/38D01D5/34
Inventor 余灯广张玲玲张瑶瑶张曼郑招斌
Owner UNIV OF SHANGHAI FOR SCI & TECH
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